Blood Group Secretors and H Extras Flashcards
Describe H substance
codes a fucosyl transferase that adds a fucose to the outer most sugar of a type1/2 precursor
Describe Bombay
absence of H ag, still have ABO genes they may transfer to offspring but dont enhibit ag themselves
Autosomal recessive bombay
fails to rx with?
serologically?
what mutation?
hh genotype produces no H ag so no ABO ag can be formed on the rbc
fails to rx with ulex. europeas (H lectin) serologically O
Fut1 gene mutation that silences fucosyltransferase
Describe parabombay
mutation?
all H available…
rbc completely devoid of H ag
exhibit small amounts of A or B ag
mutation to FUT1 that makes fucosyltransferase low reactivity
All H available is converted to A or B by functional acting A/b transferases or FUT2 is functional
Describe A1 phenotype
branched A ag
+ w Anti-A
+ w Anti-A lectin
Describe A2 phenotype
linear A ag
+ w anti-A
- w Anti-A lectin
People who have quantitively less Ag converted from H substances are called?
Subgroup people
Describe the B subgroups
B
very
B: very efficient transferase, detected by B. simp
B3
Mixed field doesnt make anti-b
BX
rxn weak w/ anti-b/anti-a,b
Bm
transferase detectable but doesnt work well
Bel
must be detect by adsorption/elution
Describe what subgroups would look like rxn wise with A
there is NO anti-A2
when a person is negative w AI lectin and positive with Anti-A they are a subgroup
T/F there is a BI lectin
false
Immune stimulated Ab
Anti-D, Anti-Le a
