Complex Ab problems Flashcards

1
Q

Test pannels in the same way you test screen cells….

A

recognize patterns

run autocontrol

phenotype

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2
Q

Abnormal results in complex ab problems

A

mixed field, positive autocontrol, non pattern match, weak reactivity, all cells positive

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3
Q

High incidence doesnt mean clinically significant
defining feature

A

may mask clinically significant positive reactivity

defining feature O in AC

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4
Q

HTLA
special test?
often?

A

has strong rxn in plasma

special test to diagnose: AB titer

often high incidence/variable reactivity

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5
Q

Low incidence

A

doesnt mean insignificant

example: anti-k anti-cw together

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6
Q

Dosage

A

weaker rxn w heterozygous

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7
Q

Non specific Ab

A

ab that have been ruled out clin significant, pattern doesnt match

unusual suspects

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8
Q

Neutralization
uses

QC: dil

Expect:

A

uses a substance to bind the Ab

QC: dilution control parallel test

Expect: Agglutination positive

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9
Q

P1

A

hydatid cyst fluid

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10
Q

Lewis

A

saliva

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11
Q

Chido/rhogers

A

serum

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12
Q

Sda

A

urine

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13
Q

I

A

breast milk

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14
Q

Adsorption
uses?
auto?
diff?

control? uses abs s against?

expect?

A

uses rbc to bind ab
autoabsorption

differential abosption

Control: uses abs serum against abs cell

Expect negative agglutination

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15
Q

Chemicals

A

destabilize bonds, break IgM ab/ag that are bonded to cell

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16
Q

Enzymes

A

enhance/depress/no effect by cutting amino acids and chains

17
Q

Phenotyping
QC positive

QC negative

A

QC positive control = hetero ag +

Negative: ag neg

18
Q

False pos in phenotyping

false neg

A

false pos: transfused cells/pos DAT

False neg: partical/hetero expression Anti-sera

19
Q

Selected panel cells

A

of cells needed depends on how many ab are left not ruled out

confirm/elim Ab ID

ID new AB when previous known ab are present