Blood Groups (After exam 1) Flashcards
Describe reaction grades
0
W+ (weak)
H (hemolysis)
1+
RBC ags Attributes
how many groups recognized by ISBT
unique?
common features?
36 groups recognized by blood bank society
>250 unique rbc ags
Ab/Ag in the blood group share common features
RBC Ags chemically
trasnferases attach….
sequence
intrinsic or extrinsic
transferases attaches oligosaccharide to glycoproteins (ABO, Lewis, P)
amino acid sequence of glycoproteins
What chromosome are Rh genes on?
Chromosome 1
Intrinsic
passes through cellular membrane (ex Rhag/Rh)
Extrinsic example
ABO outside of cell
Blood group
ag is expression is controlled by….
Ag expression is controlled by single locus gene or closely linked homologous genes w/ little to no recombination
Alleles
snp
SNPs single nucleotide polymorph altern form of gene
Ag
requirements
phenotypes expression of allels that are significantly different
1.) must be inheritable/sequenced
antithetical
co-dominent
2.) must be expressed on cell surface
Systems
same…
same genetic locus and related glycoprotein placement
Collections
sero/bio/chemically related Ag that do not fit the definition of system
700 series
low incidence Ag w/an incidence less than 1% and cannot be included in system
rare in population
901 series
high incidence ag w incidence greater than 90% cannot be included in system
Null
absence of Ag expression
due to silencer or amorph
Usual suspects
have variable frequency, can cause severe problems
Naming Ags
Genes
Ag
Alleles
Genes - italics or underlined
Ag - numbers or letters superscript
Alleles-ISBT terminology gene included with * and ISBT #
Phenotype
how a person serologically presents ag (not collections) regardless of genetics