Review: Haemostasis and Thrombosis

Question 1

screening test of choice for primary haemostasis

Answer 1

platelet count

Question 2

causes of acquired thrombocytopenia caused by platelet destruction

Answer 2

coagulopathy eg DIC
autoimmune eg ITP
hypersplenism

Question 3

causes of acquired thrombocytopenia caused by improper function of platelets

Answer 3

drugs eg aspirin/NSAIDs

renal failure

Question 4

causes of fibrin clot formation failure

Answer 4

CF deficiency - multiple or single

Question 5

causes of multiple clotting factor deficiencies

Answer 5

liver failure
vit k deficiency/warfarin therapy
DIC

Question 6

clotting test findings of multiple clotting factor deficiency

Answer 6

prolonged PT and APTT

Question 7

what consumes the clotting factors in DIC

Answer 7

bruising
purpura
bleeding

Question 8

there is m_crovascular thrombus formation in DIC

Answer 8

micro

Question 9

long-term cause of DIC

Answer 9

malignancy

Question 10

what is the problem with the vessel wall in VENOUS thrombosis

Answer 10

valve problem

Question 11

Ix DVT

Answer 11

doppler USS

Question 12

what is a d dimer

Answer 12

a fibrin breakdown product

present any time fibrin is (ie when coagulation has been activated)

Question 13

what should you give alongside warfarin when you anticoagulate?

Answer 13

give heparin for 5 days once you start warfarin

warfarin makes the situ worse before it improves

Question 14

what breaks down warfarin in the liver

Answer 14

cytochrome p450

Question 15

warfarin prolongs what clotting tests

Answer 15

APTT AND PT