Haematopoesis Flashcards
platelets have/dont have a nucleus
dont have
name the granulocytes
neutrophils
eosinophils
basophils
what do eosinophils do?
destroy parasites
modulate hypersensitivity reactions
what do basophils do?
modulate hypersensitivity reactions
how do monocytes differ morphologically from granulocytes?
nucleus is not segmented
not granular
when does a monocyte become a macrophage?
when it goes into a tissue
lifespan of neutrophils?
7-8hrs
which would be the first cell to drop in numbers if the bone marrow is non-functioning?
neutrophils
would platelets or RBCs drop in numbers first if the bone marrow is non-functioning?
platelets
earliest form of a neutrophil?
myeloblast
how does the nucleus of a neutrophil change as it develops?
it becomes more segmented as it matures
platelet precursor cell?
megakaryocyte
which cells in the bone marrow are polypoid and why?
megakaryocytes
cytoplasm doesnt divide but still forms platelets
describe the daughter cells of a haematopoetic stem cell; how many does it make?
2
1 daughter cell identical to it
1 daughter cell different to it
what cell has the ability to self renew?
haematopoetic stem cell
bone marrow starts developing at week _
16
first site of erythroid activity in development?
yolk sac
haematopoeietic stem cells originate in the __derm
meso
describe the arterial supply of the bone marrow
nutrient artery and periosteal network -> arterioles -> sinusoids
how do sinusoids differ from capillaries?
larger
discontinuous basement membrane
what are fenestrations?
gaps in bone marrow sinusoids that allow mature RBCs to leave
what happens to sinusoids when red cells are released
inc blood flow
sinusoids dilate
describe the relationship between megakaryocytes and sinusoids
MKCs extend long branching processes called proplatelets into the sinusoidal blood vessels
what is yellow marrow? when is at its most populous?
fat
when youre older
myeloid:erythroid ratio is usually…
1.5-3 : 1
neutrophil precursor maturation is regulated by…
granulocyte-colony stimulating factor
what hormone regulates growth and development of megakaryocytes?
thrombopoetin (as it eventually makes platelets)
“horseshoe nucleus”
monocyte
lymphoid cells require what extra test for assessment that non-lymphoid cells dont?
immunophenotyping
neutrophils primarily reside in the blood/tissues
tissues
what cells can marginate on the endothelial surface of BVs?
neutrophils
myelocytes are precursor cells of what cells?
neutrophils
earliest precursor cell of a macrophage after a myeloblast?
promonocyte
why do you get an neutrophilia in steroid use?
break down marginating neutrophils so they have to circulate
mast cell tryptase is released from..
mast cells
mast cell tryptase is a marker of ..
degranulation
inc mast cells
cytoplasm is minimal/plentiful in monocytes
plentiful
monocytes circulate for __ days before entering the tissues
1-2
abundant blue cytoplasm wrapping against neighbouring red blood cells….
glandular fever
non-EBV causes of glandular fever
HIV
CMV
viral hepatitis
toxoplasma
IgM antibodies confirm recent/past infection
recent
IgG antibodies confirm recent/past infection
past
