Arterial Thrombosis and Antiplatelets Flashcards
why give antiplatelets for an arterial thrombus?
thrombus is rich in platelets
describe the process of atherosclerosis
damage to endothelium recruits “foamy” macrophages rich in cholesterol which form plaques
symptoms of stable atherosclerotic plaque deposition?
stable angina
intermittent claudication
symptoms of unstable atherosclerotic plaques
acute symptoms eg
unstable angina
MI
stroke
how is an arterial thrombus formed in atherosclerosis?
plaques rupture, exposing damage (VWF release) which recruits platelets -> aggregation forming platelet plug
why is diabetes a risk for arterial thrombosis?
causes damage to endothelium
increased platelet activation
higher cholesterol = more foamy macrophages
prevention of arterial thrombosis
stop smoking treat HTN treat diabetes lower cholesterol antiplatelets
platelets bind to subendothelial collagen via what 2 things
VWF
glycoprotein 1b
platelets aggregate via..
membrane glycoproteins
fibrinogen
why do platelets alter their shape once aggregated?
to inc surface area to expose more prostaglandin for coag activation
what substances are released from the platelet plug to recruit more platelets?
thrombin
ADP
thromboxane A2
MoA of aspirin? how does this impact the platelet plug pathway?
COX inhibitor
COX is necessary to make thromboxane A2 which is responsible for recruiting more platelets to the platelet plug
aspirin side effects?
bleeding
blocks prostaglandin production
GI ulceration
bronchospasm
clopidogrel MoA?
ADP receptor antagonists
ADP is responsible for recruiting more platelets to the platelet plug
what happens if membrane glycoproteins are inhibited?
platelets cant aggregate
