Function of the Lymph Nodes and Spleen Flashcards

1
Q

where are fetal haematopoietic stem cells made?

A

liver

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2
Q

name primary lymphoid tissues

A

bone marrow

thymus

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3
Q

name secondary lymphoid tissues

A
lymph nodes
spleen
waldeyers ring (tonsils)
GI tract
BM
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4
Q

how are the spleen and lymph nodes similar?

A

both filter circulatory fluids

both locations of immune cells

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5
Q

leakage of lymph into the peritoneal cavity is called…

A

chylous ascites

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6
Q

describe the appearance of chylous ascites

A

milky

lipid rich fluid

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7
Q

how does the lymphatic system ensure direction of flow?

A

valves

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8
Q

what area of the lymph node do afferent lymph channels drain to?

A

peripheral sinus

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9
Q

what is the cisterna chyli?

A

dilated sac at the lower end of the thoracic duct that drains lymph from the lumbar/instestinal lymphatic systems

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10
Q

what are germinal centres?

A

locations in 2ndary lymphoid organs eg LNs/spleen where B cells mature and proliferate

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11
Q

the thoracic duct drains what side mainly? what does it drain?

A

left
left head/neck/thorax
all lymph below diaphragm

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12
Q

what trunks primarily drain lymph from the upper body?

A

jugular trunk
subclavian trunk
bronchomediastinal trunk

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13
Q

where in the lymph node would you find plasma cells?

A

medullary cords

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14
Q

signs of lymphangitis?

A

red lines extending from an inflamed lesion

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15
Q

generalised lymphadenopathy suggests what?

A

systemic inflammatory process

widespread malignancy

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16
Q

right lymphatic duct drains what?

A

upper right quadrant of the body

right side of the head and neck, the right side of the thorax and the right upper limb

17
Q

where does lymph drain into the venous system?

A

subclavian veins, via the right and left venous angles

18
Q

what conditions will primarily cause a B cell response?

A

autoimmune conditions

infections

19
Q

what conditions will primarily cause a T cell response?

A

drugs

VIRAL infections

20
Q

phagocytes reside where in the lymph node?

A

internal sinuses

21
Q

what site of the lymph node tends to become inflamed if a tumour drains there?

A

phagocytic region eg the internal sinuses

22
Q

lymph is a/an __udate

A

trans

23
Q

location of the spleen

A

LUQ (v high)

24
Q

blood supply to spleen?

A

splenic artery and vein

25
Q

splenic vein drains to…

A

joins with SMV to form portal vein

26
Q

describe the composition of the parenchyma of the spleen

A

red pulp

white pulp

27
Q

what is contained within the red pulp of the spleen?

A

sinusoids

cords

28
Q

what lines sinusoids?

A

endothelial cells

29
Q

what do the cords of the red pulp contain?

A

macrophages
fibroblasts
cells in transit eg RBCs/WBCs

30
Q

function of the white pulp of the spleen?

A

contains lymphoid tissue of the spleen

immune response

31
Q

how is an immune response generated by the white pulp?

A

antigen reaches white pulp via blood
APCs detect and present this to immune cells
response activated

32
Q

main composition of the white pulp of the spleen?

A

periarteriolar lymphoid sheath (PALS)

33
Q

clinical features of splenomegaly

A

dragging sensation in LUQ

pain while eating

34
Q

give the triad of features of hypersplenism

A
  1. splenomegaly
  2. fall in one or more cellular blood contents
  3. correction of cytopenias
35
Q

haematological causes of splenomegaly

A

lymphoma/leukaemia
haemolytic anaemia
ITP
myeloproliferative disease

36
Q

autoimmune causes of splenomegaly

A

ITP
RA
SLE

37
Q

causes of hyposplenism

A

splenectomy
coeliac disease
sickle cell
sarcoidosis

38
Q

features of reduced red cell pulp function on blood film?

A

howell jolly bodies

red cell abnormalities