Concepts in Haematology

Question 1

why might the cell count be low?

Answer 1

inc destruction
reduced production
redistribution

Question 2

why might the cell count be high?

Answer 2

inc production in response to stimulus
inc production with no stimulus (malignancy)
redistribution

Question 3

steroids cause an increase in what cell? why is this

Answer 3

neutrophils

cause redistribution of neutrophils to a more easily sampled place (production HASNT gone up)

Question 4

-cytosis and -philia means an excess/lack

Answer 4

excess

Question 5

-penia means an excess/lack

Answer 5

lack

Question 6

difference between reticulocytes and RBCs

Answer 6

have RNA but no nucleus (precursors to RBCs)

RBCs dont have RNA

Question 7

what 2 substances catalyse biochemical steps to cell division

Answer 7

B12

folic acid

Question 8

what cells detect hypoxia? where do they do this?

Answer 8

fibroblasts

peritubular capillaries and PCT of kidney

Question 9

what does inc erythropoetin cause and why?

Answer 9

erythroid hyperplasia

stimulates production of red cell precursors eg reticulocytes

Question 10

iron absorption occurs where?

Answer 10

duodenum and proximal SI

Question 11

name the raw materials for RBC production

Answer 11

iron stores
globin synthesis
haem

Question 12

you get jaundice from the inc bilirubin in chronic hypoxia T or F

Answer 12

F, system has time to adapt so wont