Review

Question 1

LIVER

•Composed of ___and ____
•Functional unit:____

Answer 1

hepatocytes and Kupffer cells

lobules

Question 2

Functions of LIVER

Answer 2

• Metabolism
• Excretion/Secretion
• Detoxification
• Storage

Question 3

Fractions of Bilirubin

Answer 3

B1 - unconjugated
B2 - conjugated

Question 4

B1

Answer 4

• Bilirubin monoglucoronide
• Unconjugated bilirubin
• Water-insoluble bilirubin
• Indirect bilirubin
• Nonpolar bilirubin

Question 5

B2

BCPWD

Answer 5

• Bilirubin diglucuronide
• Conjugated bilirubin
• Water-soluble bilirubin
• Direct bilirubin
• Polar bilirubin

Question 6

Types of jaundice

Answer 6

•Prehepatic Jaundice
•Hepatic Jaundice
•Post Hepatic Jaundice

Question 7

Nonfunctional liver for 24 hrs =

Answer 7

hypoglycemia

Question 8

•Refers to serum or plasma with yellow discoloration due to elevated bilirubin

Answer 8

Icterus

Question 9

of blood passes thru liver PER MINUTE

Answer 9

1,500 mL

Question 10

The conjugation (esterification) of bilirubin occurs in the presence of the enzyme___________, which transfers a glucuronic acid molecule to each of the two propionic acid side chains of bilirubin to form bilirubin_____, also known as_____ bilirubin.

Answer 10

uridine diphosphate glucuranosyltransferase (UDPGT)

diglucuronide

conjugated

Question 11

Once at the liver cell, unconjugated bilirubin flows into the sinusoidal spaces and is released from albumin so it can be picked up by a carrier protein called _____.

______, which is located in the hepatocyte, is responsible for transporting unconjugated bilirubin to the endoplasmic reticulum, where it may be rapidly conjugated.

Answer 11

Ligandin