Response to pH change in Hb

Question 1

H+ binds at what affinity to deoxyHb

Answer 1

Higher affinity

Question 2

In the deoxy form His146 forms what with Asp94

Answer 2

A salt bridge if His is protonated

Question 3

What is the result of the salt bridge for His146 in terms of pKa

Answer 3

Has a higher pKa

Question 4

at pH 7.4, His146 is largely what

Answer 4

unprotonated in the OcxyHb form

Question 5

H+ favours what form and so promotes what

Answer 5

deoxyHb form and promotes release of O2