Domains Flashcards
1
Q
What is a domain
A
Its a compact, locally folded region of tertiary structure
2
Q
How are domains interconnected?
A
A polypeptide strand that runs the length of the protein
3
Q
Small proteins contain how many domains and larger proteins contain how many domains
A
Small proteins have one. Larger proteins have multiple domains
4
Q
Domains have stable structures when what
A
isolated from the native protein
5
Q
How is the domain isolated from the native protein
A
Proteolytic Cleavage
6
Q
A domain is usually constructed from what
A
A section of polypeptide that contains 50-350 residues
7
Q
Limited flexibility between domains is often crucial to what?
A
Substrate binding, allosteric control and assembly of large structues
