Allosteric effector

Question 1

BPG acts as what

Answer 1

an allosteric effector

Question 2

Binding of BPG acts to lower what

Answer 2

oxygen affinity to hemoglobin

Question 3

BPG binds where in the B chains and does what

Answer 3

BPG binds in the cavity between the β chains, making electrostatic interactions with positively charged residues around the opening

Question 4

BPG can only bind to what form

Answer 4

deoxyHb form the cavity in the oxyHb form is because the cavity in the oxyHb form is to small to accommodate BPG.

Question 5

The higher the BPG in red blood cells the what

Answer 5

the more stable deoxyHb and decrease in O2 affinity

Question 6

Sickle Cell Anemia

Answer 6

Is a genetic disorder caused by a single amino acid substitution (Glu6 to Val6) in each β-chain of hemoglobin.The change introduces hemoglobin. The change introduces a hydrophobic patch on the surface of hemoglobin that causes molecules to aggregate into bundles of fibres