Irreversible Inhibitors

Question 1

Name 2 irreversible inhibitors?

Answer 1

Suicide inhib
Trojan horse

Question 2

What do these 2 inhibitors inhibit?

Answer 2

Acetylcholinesterase

Question 3

How can iodocetamide inactivate an enzyme? And what does the kinetic pattern look like

Answer 3

By reacting with critical cysteine residues. Non competitve inhibition

Question 4

what does TPCK do?

Answer 4

Resembles the susbstrate and modifies an essential histidine in the catalytic triad

Question 5

What does penicillin do and what type of substrate isit?

Answer 5

Irreversibly inactivates a key enzyme in bacterial cell wall synthesis.
Penicillin is a suicide substrate
Resemebles non-competitive

Question 6

Something about transition state analogs

Answer 6

Transpeptidation reaction leads to cross link formation