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Pharmacology (2014-2018) > Reproductive system drugs > Flashcards

Reproductive system drugs Flashcards

1
Q

Production of which hormone is increased by follicle-stimulating hormone?

a) Estradiol
b) Progesterone
c) Androgen
d) Luteinizing Hormone

A

A

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2
Q

Which of the following is a steroidal synthetic sex hormone?

a) Ethinyl estradiol
b) Estradiol
c) Estrone
d) Diethylstilbestrol

A

A

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3
Q

Medroxyprogesterone acetate has all of the following actions except

a) Stimulates aromatase
b) Activates 17-hydroxysteroid dehydrogenase
c) Inhibits the replenishment of estrogen receptors in the cell
d) Induces sulfotransferase

A

A

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4
Q

This estrogenic drug may cause vaginal carcinoma
in the female offspring during puberty

a) Clomiphrene
b) Diethylstilbestrol
c) Danazol
d) Ethinyl estradiol
e) Mestranol

A

B

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5
Q

Which of the following is/are recognized effect/s of oral contraceptives?

a) Decrease risk of ovarian cancer
b) Decreased risk of cervical cancer
c) Increased risk of endometrial cancer
d) AOTA

A

A

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6
Q

Which is the mechanism of action of COCs?

a) The estrogenic agent suppresses LH and the progestational agent suppresses FSH

b) The estrogenic agent suppresses FSH and
the progestational agent suppresses LH

c) The estrogenic and the progestational
agents suppress LH

d) The estrogenic and the progestational agents suppress FSH

A

B

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7
Q

Thromboembolism has been associated with the use of oral contraceptives that have an excess of

a) Estrogen
b) Testosterone
c) Progestin
d) Prostaglandins
e) Aldosterone

A

A

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8
Q

All of the following are recognized effects of natural
androgens or androgenic steroids except

a) Growth of facial hair
b) Induction of a growth spurt in pubertal boys
c) Increase in muscle bulk
d) Increase in production of breast milk in women

A

D

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9
Q

Leuprolide is GnRH agonist and anti-androgen whose mechanism of action is

a) Inhibition of androgen synthesis
b) Suppression of androgen release
c) Receptor blockade
d) NOTA

A

A

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10
Q

Which of the following statements is correct?

a) The primary targets of FSh activity are the ovarian granulosa and testicular sertoli cells
b) The primary targets of LH activity are the ovarian granulosa and testicular leydig cells
c) The primary targets of FSH activity are the ovarian theca and testicular leydig cells
d) The primary targets of LH activity are the ovarian theca and testicular sertoli cells

Answer: A

A

A

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11
Q

The correct combination of drug and its mechanism of action

a) Flutamide – androgen synthesis inhibitor
b) Clomiphene – estrogen synthesis inhibitor
c) Mifepristone – progesterone synthesis inhibitor
d) Letrozole – estrogen receptor antagonist
e) Spionolactone – androgen receptor

antagonis

A

E

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12
Q

The two-cell, two gonadrotropin theory of the
control of steroidogenesis

a) States that the rate of aromatization in the granulosa cell is directly related to the
androgen substrates

b) States that stimulation of the FSH receptors in the sertoli cells increase androgen synthesis
c) States that stimulation of the LH receptors increase the production of androgen binding proteins

A

A

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13
Q

Aside form an intact hypothalamic pituitary ovarian
axis, the prerequisites for a normal menstruation include

a) Estrogen-induced proliferative endometrium
b) Ovulation at midcycle
c) Progesterone induced secretory endometrium
d) AOTA

A

D

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14
Q

The reduced androgenicity of the new progestins is secondary to the following reasons

a) Increased SHBG and decreased free testosterone concentrations
b) Decreased SHBG and decreased free testosterone concentrations

c) Increased SHBG and increased free
testosterone concentrations

d) Decreased SHBG an decreased free testosterone concentrations

A

A

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15
Q

The rationale for the therapeutic use of conjugated
estrogens for immediate treatment of dysfunctional
uterine bleeding is based on the fact that estrogen

a) Causes atrophy of the endometrium
b) Leads to decidualization of the endometrium
c) Leads to rapid proliferation of the endometrium
d) AOTA

A

C

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16
Q

True of metabolic effects of estrogen

a) Increases HDL
b) Decreases LDL
c) Decreases triglyceride
d) AOTA

A

A

17
Q

The hormonal changes after menopause include

a) Decreased inhibin, increased FSH, normal LH, slightly decreased estradiol

b) Decreased inhibin, increased FSH and LH,
decreased estradiol

c) Decreased inhibin, decreased FSH and LH, and slightly increased estradiol
d) Decreased inhibin, increased FSH, normal LH, increased estradiol

A

A

18
Q

Choose the correct statement/s regarding the
principles in the use of HRT

a) HRT is not effective in perimenopause to regulate the menstrual cycle
b) The highest effective estrogen dose may be used for the shortest possible time to alleviate menopausal symptoms

c) The risks and benefits of HT are the same for women around the same time of
menopause compared to those for older women

d) AOTA

A

*

19
Q

The following is/are indication/s for HRT use as
recommended by the FDA

a) Treatment of osteoporosis
b) Treatment of moderate vasomotor symptoms
c) Treatment of cardiovascular disease
d) AOTA

A

B

20
Q

Absolute contraindication/s to the use of HRT include/s

a) Untreated hypertension
b) Recent myocardial infarction
c) Active liver disease
d) AOTA

A

D

21
Q

A 68 year old patient with hip fracture underwent Dual Energy Xray Absorptiometry screening test showing T scores of -1.8 at the spine and -1.9 at the hip. The following statement/s is/are correct

a) Since patient is hypoestrogenic, bone
remodeling increases leading to increased bone resorption

b) Patient has severe osteoporosis

c) Reduction in trabecular bone is greater than reduction in cortical bone in the first 20
years of menopause

d) AOTA

A

D

22
Q

The use of estrogen replacement therapy

a) Protects against endometrial cancer
b) Protects against cervical cancerc) Protects against colorectal cancer
d) Protects against ovarian cancer

A

C

23
Q

Choose the correct statement/s

a) Perimenopause is marked by irregularity of the menstrual cycle
b) The administration of large amounts of estrogen will lower the FSH levels to premenopausal concentrations
c) A BMI of > 30 is a risk factor for myocardial infarction
d) AOTA

A

A

24
Q

Tibolone is a viable alternative to HRT because

a) It may protect against cervical cancer
b) It may protect against colorectal cancer
c) It may protect against breast cancer
d) It may protect against ovarian cancer

Answer; C

A

C

25
Q

The following agents that are used for the prevention of post menopausal osteoporosis to reduce the incidence of vertebral and hip fractures

a) Estrogen
b) Risedronate
c) Raloxifene
d) A & B
e) AOTA

A

D

26
Q

Choose the best route of administration of HRT for a 60 year old patient complaining of severe vaginal dryness

a) Oral route (tablet)
b) Non-oral route (patch)
c) Vaginal route (Vaginal tablet)
d) Any of the above routes of administration

A

C

27
Q

True of the effects of estrogen deficiency from perimenopause to advanced age

a) Early – hot flushes
b) Intermediate – dyspareunia
c) Late – atherosclerosis
d) AOTA

A

D

28
Q

The pathognomic symptom of menopause

a) Hot flush
b) Menstrual irregularity
c) Low back pain
d) Mood swings

A

A

29
Q

Age of menopause may be determined by

a) Age of menopause of the patient’s mother
b) Age of menarche of the patient
c) Age of menarche of the patient’s mother
d) AOTA

A

A

30
Q

The following are the effects of estrogen therapy on the lipid profile

a) Decreased total cholesterol, decreased LDL, increased HDL, increased triglycerides
b) Increased total cholesterol, increased LDL, decreased HDL, decreased triglycerides
c) Decreased total cholesterol, decreased LDL, increased HDL, decreased triglycerides

d) Decreased total cholesterol, decreased LDL, decreased HDL, decreased
triglycerides

A

A

31
Q

True of hormone production after menopause

a) Increased facial hair is secondary to the changes in androgen estrogen ratio
b) Higher levels of estradiol are produced from the increased conversion of androstenedione with advancing age
c) A slim postmenopause woman has a lower risk of experiencing vasomotor symptoms compared to an obese postmenopause woman
d) AOTA

A

A

Pharmacology (2014-2018) (23 decks)

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