Intro to CNS and autonomic pharmacology Flashcards
In which of the following conditions/structures is the blood brain barrier compromised?
A. CNS infection
B. Premature infants
C. Area postrema
D. AOTA
D
Characteristic of a voltage-gated Na channel
A. Found on 1st part of dendrites
B. Modulates rate of neuron discharge
C. Mediates signal from cell body to nerve terminal
D. Slow acting
C
Which of the following receptors activated by glutamate is partially voltage gated?
A. APMA
B. KA
C. NMDA
D. NOTA
C
Norepinephrine enhances excitatory inputs by which of the following mechanisms?
A. Hyperpolarize neurons by increasing potassium conductance
B. Disinhibition of inhibitory local circuits
C. Blocking potassium conductance
D. B and C
D
Which of the following is selective for GABAB receptors?
A. Diazepam
B. Baclofen
C. Phenobarbital
D. Muscimol
B
Which of the following statements describes the property of synaptic mimicry in the identification of central neurotransmitters?
A. The transmitter must be shown to be present in the presynaptic terminals of the synapse and in the neurons from which those presynaptic terminals arise
B. When applied experimentally to the target cells, the effects of the putative transmitter should be identical to the effects of stimulating the presynaptic pathway
C. The transmitter must be released from the presynaptic nerve concomitantly with presynaptic nerve activity
D. NOTA
B
Which of the following is a characteristic of local circuit neurons in hierarchical systems?
A. Interconnect pathways over large distances
B. Majority are inhibitory, releasing GABA or glycine
C. Large cell bodies
D. Involve ionotropic receptors
B
Which of the following is TRUE regarding diffuse systems in the cellular organization of the brain?
A. Systems involved in sensory perception and motor control
B. Clearly delimited in their anatomic distribution
C. Conduct slowly at 0.5 m/s
D. Information is processed by successive integration circuits
C
Which of the following organs/structures would have predominantly sympathetic tone at the effector sites?
A. Heart
B. Arterioles
C. Urinary bladder
D. Ciliary muscle
B
Presynaptic fibers come from the craniosacral outflow.
A. If statement applies to sympathetic NS only
B. If statement applies to parasympathetic NS only
C. If statement applies to both
D. If statement applies to neither
B
Preganglionic fibers terminate in the ganglion in wall of target organs
A. If statement applies to sympathetic NS only
B. If statement applies to parasympathetic NS only
C. If statement applies to both
D. If statement applies to neither
B
It is not under direct conscious control
A. If statement applies to sympathetic NS only
B. If statement applies to parasympathetic NS only
C. If statement applies to both
D. If statement applies to neither
D
Which of the following is ligand-gated?
A. 5-HT1
B. 5-HT2a
C. 5-HT3
D.5-HT4
C
Which of the following is the BBB less impermeable?
a. cerebral ischemia
b. premature infants
c. area postrema
d. median eminence
e. aota
E
Which of the following are characteristics of voltage gated sodium channels?
a. found on the initial segment of dendrites
b. modulate rate of neural discharge
c. mediates signal from the cell body to the nerve terminal
d. action is of a slower time scale
C
