Pharmacogenetics Flashcards
The following conditions have X-linked type of inheritance EXCEPT
A. G6PD deficiency
B. Pyridoxine sensitive anemia
C. Vasopressin resistance
D. Aminoglycoside-induced deafness
D
Pharmacogenetics is the study of genetically controlled variations in drug response. Which condition listed below is considered to be pharmacogenetic?
A. Malignant hyperthermia
B. Oligondontia
C. Waardenburg syndrome
D. Treacher Collins syndrome
A
The probe drug used in pharmacogenetic study of CYP2D6
A. Isoniazid
B. Debrisoquine
C. Azathioprine
D. Succinylcholine
B
Increased risk of cancer is associated with the following polymorphism
A. NAT2
B. TPMT
C. G6PD
D. CYP2D6
A
Severe hemolytic anemia after administration of antimalarial agent primaquine is seen in individuals deficient with this enzyme
A. Homogentisate 1,2-dioxygenase
B. Glucose-6-phosphate dehydrogenase
C. Dihydropyrimidine dehydrogenase
D. Glutathione transferase
B
Which of the following is the most common type of polymorphism in the human genome?
A. Various tandem repeats
B. Insertion polymorphism
C. Deletion polymorphism
D. Single nucleotide polymorphism
D
To maintain concentrations similar to CYP 2D6 extensive metabolizers, the dose of nortriptylline given to poor metabolizers should be
A. Increased
B. Decreased
C. The same
D. Any of the above
A
Which of the following would you expect in NAT2 fast/rapid acetylators compared to slow acetylators?
A. Lower concentration of isoniazid at any dose
B. Higher incidence of hydralazine-induced lupus erythematosus
C. Faster appearance of antinuclear antibodies with procainamide
D. Decreased risk of colon cancer with heterocyclic amines from cooked amines
A
Administration of 6-mercaptopurine (6MP) in children with low intracellular activity of thiopurinemethyltransferase (TPMT) for acute lymphoblastic leukemia will result in
A. Profound myelosuppression
B. Cancer cell lysis
C. Therapeutic failure
D. Methemoglobinemia
A
The “atypical alcohol dehydrogenase” variant beta-2 subunit is responsible for a
A. Lower ethanol Vmax of the atypical enzyme
B. Lower plasma level of acetaldehyde metabolite
C. Higher Km for the homozygous B2B2
D. Higher intracellular activity of the alcohol dehydrogenase enzyme
C
Dibucaine number is indicative of possible abnormality in
A. Tyrosine hydroxylase
B. Catechol-O-methyltransferase
C. Pseudocholinesterase
D. Monoamine oxidase
C
The accumulation of trimethylamine that can cause “Fish odor Syndrome” is due to what genetically determined
A. Hydrolysis
B. N-oxidation
B
Benefit of pharmacogenetics:
A. Better vaccines
B. Better dosage regimens
C. Decreased cost of health care
D. A or B
E. AOTA
*
Which is the correct pair of
prostaglanding to its function
A. PGE1 analog (misoprostol) – gastric
cytoprotection
B. PGE2 (alp something) –migraine and
major depression
C. PGI2 (…) – renal arteriolar
vasodilation
D. PGE2 alpha – alopecia
*
The following are true of succinylcholine
sensitivity:
A. A patient who receives a
neuromuscular blocking agent like
succinylcholine takes a longer recovery of
respiratory function
B. It is due to pseudocholinesterase
deficiency.
C. Anaesthetic agents given to patients
will produce high grade fever and rigidity
D. AOTA
E. A and B only
*
