Developmental Pharmacology Flashcards
If a child is malnourished
A. Penicillin excretion increases
B. Vd of tetracycline increases
C. Salicylate plasma binding decreases
D. Chloramphenicol excretion decreases
C/D
Drug that causes patent ductus arteriosus to remain open, as life-saving measure in neonates with transposition of great vessel
A. Indomethacin
B. Ibuprofen
C. Prostaglandin E1
D. Aspirin
C
Lipophilic drugs have low Vd in prematures because of
A. Immaturity of the kidney
B. Low amount of enzymes in liver
C. Low water content of the body
D. Small amount of fat tissues in the body
D
The following phase II metabolizing enzymes have low activity at birth EXCEPT
A. Glucuronidation
B. Sulfatation
C. Acetylation
D. Methylation
B
Skin testing in neonates to detect allergy to penicillin will not be informative because
A. Erractic absorption of parenteral penicillin
B. Thinner stratum corneum especially in preterm
C. Absence of histamine in the skin until 3rd week of life
D. Small volume of drug compared to weight and surface area ratio
C
At 4th to 10th week AOG, fetus is more prone to concern about drug-induced fetal
A. Cardiac arrest
B. Hemorrhage
C. Malformations
D. Jaundice
C
Tetracycline is NOT recommended for children below 8 years old because it can cause
A. Enamel dysplasia
B. Fetal hydantoin syndrome
C. Bone marrow suppression
D. Cerebral palsy
A
Which is true regarding drug absorption in children?
A. Intestinal motility in children is slower than in newborn
B. Delayed gastric emptying time in children results to less absorption
C. Suspension is better absorbed than liquid dosage
B
Lipophilic drugs have low Vd in premature babies because:
A. Kidney immaturity
B. Low amount of liver enzymes
C. Low amount of body fat
D. Little fat tissues
B
Most drugs taken by pregnant women are capable of crossing the placenta and reach the developing fetus. The placenta itself can aid in the protection of the fetus from
excessive exposure to drugs in the maternal circulation by:
A. Impairing diffusion of lipid soluble drugs
B. Preventing passage of drugs having molecular weight under 250
C. Playing a role as a site of drug metabolism
D. Secreting drugs from the fetal circulation to the maternal circulation
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Factor than can facilitate the passage of drugs from blood-organ barriers:
A. Complete anatomic development of barrier
B. Decreased permeability of the membrane
C. Complete myelinization in the brain
D. Acidosis and hypoglycaemia
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