Drug action and fate during special conditions Flashcards
The most common form of dermatological
manifestation of allergic drug reactions:
A. Melasma
B. Angioedema
C. Morbiliform rash
D. Papular rash
C
A delayed adverse drug reaction to fertility
drugs.
A. Ovarian cancer
B. Uterine benign tumor
C. Both
A
OA with CHF… Digitalis is notorious for causing:
A. Hyponatremia
B. Hypokalemia
C. Hypocalcemia
D. None of the above
B
Pharmacogenetic variations that may appear as
unusual response to a drug:
A. Warfarin resistance
B. Hemolytic anemia after taking
C. Malignant hyperthermia following use
D. All of the above
acetanilide
of halothane
C
The prodrug used in pharmacogenetic study
of CYP 2D6:
A. Deprisoprine
B. Parathion
C. Dihydropyrimidine dehydrogenase
D. Nortiptyline
A
Increased risk for cancer is associated with
the following genes:
A. NAT 1
B. NAT 2
C. Both
B
Which of the following is the most common
type of polymorphism in the human
genome?
A. Deletions
B. Single Nucleotide Polymorphisms
(SNP)
C. Chimera gene
B
An atypical ADH (alcohol dehydrogenase)
variant of the beta 2 subunit is responsible for:
A. a lower ethanol Vmax for the atypical
enzyme
B. a lower plasma level of the acetaldehyde
metabolite
C. a higher Km for homozygous B2B2
D. a higher intracellular activity of the
alcohol dehydrogenase enzyme
C
A patient has a liver problem resulting to
decreased albumin in blood. Which is true:
a. the volume of distribution of lipophilic is more
affected than hydrophilic
b. the volume of distribution of hydrophilic is more
affected than lipophilic
c. no change in Vd
d. change in Vd cannot be predicted
B
Slow acetylators of isoniazid are predisposed to:
A. cardiopathy
B. peripheral neuropathy
C. renal failure
D. liver failure
B
Drug that should be avoided by patients with Brugada syndrome
A. Azithromycin
B. Amiodarone
C. Terfenadine
D. AOTA
D
