Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology (2014-2018) > Autocoids > Flashcards

Autocoids Flashcards

1
Q

The following is a histamine-2 receptor antagonist used to decrease gastric acidity

A. Chlorphenamine
B. Ranitidine
C. Cetirizine
D. Loratidine

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The following is false with regard to KKK system

A. Bradykinin is associated with vasodilation
B. The KKK-system is not activated by tissue damage
C. HMW kininogen is an important factor in activating the intrinsic clotting pathway
D. Aprotonin is a kallikrein inhibitor important in reversing bleeding due to the effects of heparin

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is false about histamine?

A. Found in areas prone to injury like the nose, skin, mouth, feet
B. Stored in macrophages and neutrophils
C. Powerful secretagogue of GI secretions
D. Have a central role in immediate hypersensitivity and allergic response

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which of the following is not a known function of 5-hydroxytryphtophan?

A. Regulation of GI motility
B. Central chemical transmitter for tryptaminergic neurons in the brain
C. Dilatation of the bronchi
D. Precursor for melatonin

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which of the following is not a known physiological effect of angiotensin?

A. Decreases ADH secretion
B. Stimulates synthesis and secretion of aldosterone
C. Arteriolar vasoconstriction
D. Promotes cardiac muscle and vascular hypertrophy

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The following is considered false information about aspirin?

A. Inhibits the generation of thromboxane A2
B. Decreases gastric mucosal production especially in higher doses
C. A known analgesic and anti-pyretic
D. Reversible inhibitor of platelet function for 72 hours duration

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The following is not an associated function of the leukotrienes

A. Promotes contraction of smooth muscles of the bronchial airways
B. Stimulates the production of proinflammatory cytokines
C. Promotes the secretion of mucous in the bronchial glands
D. Inhibits the transendothelial migration of neutrophils

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How viruses choose specific cell tissue organ etc. to attach to

A. Viral proteins
B. Capsid adherence
C. Host cell receptor
D. Envelope solubility

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which is not an H1 antagonist?

A. Chlorphenhydramine
B. Cimetidine
C. Diphenhydramine
D. Loratadine

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which of the following is an example of a non-selective 5HT receptor agonist originally for migraine headaches but has many side effects, such as paresthesia, nausea, vomiting disturbances, and muscle weakness?

A. Buspirone
B. Trazodone
C. Ergotamine
D. Ketanserin

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Not a known function of leukotriene?

A. Contract smooth muscle
B.
C. Secrete mucus
D. Inhibits transendothelial migration of

neutrophils

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which of the following agents acting on the autonomic ganglia is used clinically to treat hypertension?

A. Trimethaphan
B. Hexamethonium
C. Epibatidine
D. Lobeline

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which of the following is incorrect about KKK?

A. Bradykinin can induce vasodilation and cough
B. something activate intrinsic clotting pathway
C. Tissue damage inactivates KKK
D. something glycemic control

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

An antihypertensive drug that activate the alpha adrenoceptor

A. Clonidine
B. Prazosin
C. Labetalol
D. Yohimbine

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Contraindicated for systemic administration:

A. Anaphylaxis
B. Myelproliferative (blood sickness) disease
C. Atopic Dermatitis
D. Post-adrenalectomy

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Cholinesterase inhibitor for Alzheimer’s dementia

B. Rivastigmine
D. Pilocarpine

A

*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

1 Incorrect association between histamine and its distribution in organs.

a. H1 – extravascular smooth muscle
b. H2 – gastric parietal cells
c. H3 – CNS
d. H4 - myocardial cells

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

not H1 antagonist

a. cimetidine
b. chlorophenydramine
c. diphenhydramine
d. loratidine

A

A

19
Q
  1. Incorrect about Kallikrein-kininogen-kinin/KKK system:
    a. Bradykinin causes vasodilation and cough
    b. High molecular weight kinninogen is important in activation of intrinsic clotting pathway
    c. Aprotinin which inhibits kallikrein à reverse bleeding due to heparin
    d. Tissue damage cannot activate KKK
A

D

20
Q

Not a function of 5ht

a. Regulation of GI motility and peristalsis
b. Bronchodilation
c. Central chemical transmitter for tryptaminergic neurons of the brain

A

D

21
Q

Incorrect match between the 5HT receptor antagonist / agonist drugs with their clinical use

a. 5HT3 Antagonist / ondansetron – nausea, vomiting
b. 5HT4 agonist / Cisapride – anxiety/depression
c. 5HT 1D agonist / Sumatripan – migraine
d. 5HT2A Antagonist / Ketaneserin – hypertension

A

B

22
Q

Example of non-selective 5HT receptor antagonist:

a. Buspirone
b. Trazodone
c. Ergotamin
d. Ketanserin

A

C

23
Q

The gastrointestinal bleeding from aspirin is considered:

a. side effect
b. extension effect
c. drug toxicity
d. medication error

A

A

24
Q

Autacoids involved in inflammatory reaction, EXCEPT

a. Histamine
b. Bradykinin
c. Serotonin
d. Prostanoids
e. Angiotensin II

A

E

25
Q

The following physiologic effects are mediated by histamine EXCEPT

a. Vasodilatation
b. Increased vascular permeability
c. Relaxation of intestinal smooth muscles
d. Stimulation of sensory nerve endings

A

C

26
Q
  1. H1 blockers (traditional / older antihistamines) have the following effects:
    a. Promote sedation
    b. Relieve allergic manifestations on the skin and mucous membrane
    c. Emesis
    d. All of the above
    e. A and B only
A

D

27
Q
  1. Which of the following is least sedating
    a. Loratadine
    b. Chlorpenamine
    c. Diphenhydramine
    d. Clemastine
A

A

28
Q
  1. What are the therapeutic uses of the H1 blockers? ALL EXCEPT
    a. As a sleeping aid
    b. For countering motion sickness
    c. To moisten the mouth and throat
    d. To relieve itching and rashes in allergic disease
A

C

29
Q
  1. Body functions where 5-HT in involved
    a. Fertility
    b. Feeding
    c. Sleeping
    d. Mentation
    e. All of the above
A

E

30
Q
  1. The enzyme responsible for converting tryptophan to serotonin belongs to what class
    a. Lipoxygenase
    b. Hydroxylase
    c. Peroxidase
    d. Transferase
A

B

31
Q

Prostanoids have the following actions/clinical significance

a. Platelet function
b. Inflammatory reaction
c. Reproduction
d. A and B only
e. All of the above

A

E

32
Q

Enzyme inhibited by NSAIDs like aspirin and ibuprofen

a. Cyclooxygenase 1
b. Cyclooxygenase 2
c. Lipoxygenase
d. All of the above
e. A and B

A

E

33
Q
  1. Which of the following anti-inflammatory agents is unique that it binds to its receptor irreversibly?
    a. Ibuprofen
    b. Mefenamic acid
    c. Acetaminophen
    d. Aspirin
A

D

34
Q
  1. An example of lipoxygenase inhibitor is:
    a. Celecoxib
    b. Zileuton
    c. Montelukast
    d. Misoprostol
A

B

35
Q

Histamine

a. has powerful effects on smooth and cardiac muscles
b. endothelial cells and nerves
c. more effect on guinea pigs than humans
d. gastric acid secretion
e. AOTA

A

D

36
Q

Traditional antihistamines with sedative effect include

a. Diphenhydramine
b. Loratadine
c. Cetirizine
d. AOTA
e. A&C only

A

A

37
Q
  1. Actions mediated by H1 blocker but not through H1 receptor
    a. Bronchia; and GI smooth muscle relaxation
    b. Endothelial constriction resulting in increased muscular permeability
    c. Dilation of vascular smooth muscle from NO from EDRF
    d. sedative, antinausea effect
    e. AOTA
A

D

38
Q

Serotonin is found in:

a. Enterochromaffin cells, 90% of the body
b. Platelets which are able to concentrate the amine by means of active SERT
c. Nerve endings, particularly brain serotonergic neurons as transmitter.

d. AOTA
e. B&C only

A

D

39
Q

5HT in brain serotonergic neurons are involved in

a. mood, depression, anxiety
b. sleep, apetite and vomiting
c. pain, temperature regulation, migraine
d. AOTA
e. A and C only

A

D

40
Q

Selective serotonin include:

a. Sumatriptan, 5HT1A/1D antagonist, for migraines and cluster headaches
b. buspirone, 5HT1 agonist used as a widely accepted anxiolitic
c. Ondesterone, 5HT3 for chemotherapy antiemesis
d. AOTA
e. B&C only

A

B

41
Q

Angiotensin II and III effects are reversed by

a. renin inhibitors of synthesis or release
b. angiotensin converting enzyme inhibitors
c. kininase II inhibitors
d. angiotensin receptor antagonist
e. AOTA

A

E

42
Q
  1. The potency of ACE inhibitors like captopril can be explained by a dual action:
    a. inhibition of synthesis of a powerful vasoconstrictor
    b. inhibition of destruction of a powerful vasodilator
    c. stimulation of synthesis of a powerful vasodilator
    d. AOTA
    e. A and B only
A

E

43
Q

Prostaglandin sunthesis is blocked through several pathways

a. lipoxygenase pathway, site of action of leukotriene inhibitors
b. cyclooxygenase pathway, site of action of aspirin and NSAIDS
c. Phospholipase enzyme, site of direct action of corticosteroids
d. AOTA
e. B&C only

A

B

44
Q

A vasoactive compound known to be the most potent vasoconstrictor

A) angiotensin I

B) angiotensin II

C) Leukotriene

D) Bradykinin

A

*

Pharmacology (2014-2018) (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions