Reproductive Health Flashcards
What are steroid hormones synthesised from?
Cholesterol
How do steroid hormones exert an effect?
Via nuclear receptors affecting gene transcription
Name 2 actions of oestrogen
decrease bone reabsorption and sodium and water retention
Name 2 side effects of oestrogen
Thromboembolism and cancers
Name 2 actions of progesterone
Fluid retention and mood changes
Name 2 side effects of progesterone
Weight gain and Acne
What is oestrogen excreted in the urine as?
glucuronides and sulfates
What is injected progesterone bound to?
albumin
What does soya protein products do to oestrogen?
Enhance absorption reducing its storage and half life
Why is HRT prescribed?
Symptoms of menopause and osteoporosis
What are the risks of opposed oestrogen?
Breast cancer
What are the risks of unopposed oestrogen?
Endometrial and ovarian cancers
What may a progesterone receptor antagonist be used for?
Termination of pregnancy by sensitising the myometrium to prostaglandin induced contractions
What is a pro drug?
A biologically inactive compound that can be metabolised by the body to form a drug (e.g. tamoxifen)
