Arrhythmia Drugs Flashcards
What causes Torsades arrhythmia?
Drug-induced prolonged QT interval
Where is the fast cardiac action potential?
Cardiac tissue
Where is the slow cardiac action potential?
SA/AV node
The bundle of kent causes which syndrome?
Wolf-Parkinson-White syndrome
What classification is used for anti-arrhythmic drugs?
Vaughan-Williams Classification
What are class 1B agents used for?
acute ventricular tachycardia
How is Lidocaine and Mexiletine administered?
L - IV, M- oral
How do class 1B agents work?
Increase threshold for sodium, decreasing the sensitivity of the heart to electrical impulses
What are class 1C agents used for?
Supra-ventricular tachycardia and Wolff-Parkinson-White syndrome
How do class 1C agents work?
Slows phase 0 and reduces automaticity
What are class 2 agents and how do they work?
Beta blockers, treat sinus and catecholamine dependent tachycardia. Increases Action potential duration
Whats does amiodarone do and what is it used for?
Very wide spectrum, useful for life threatening arrhythmias, slows phase 0, increases threshold, and increases refractory period
What does sotalol do and how does it work?
Wide spectrum, SVT and VT, increase APD and refractory period, slows AV conduction
What do class for agents do and what are they used for ?
Used to control ventricles during supraventricular tachycardia, act by slowing conduction through AV node and increasing the refractory period in AV node
What is the action of adenosine?
causes hyperpolarisation by potassium efflux, decreasing APD and slowing AV conduction. Used to convert re-enterent supraventricular tachycardias
