GI Pharmacology

Question 1

Name 2 medications that exacerbate GORD

Answer 1

Alpha-blockers and anti-cholinergics

Question 2

What type of drug is used to treat GORD?

Answer 2

PPI

Question 3

How is H.pylori treated in gastritis?

Answer 3

PPP and 2 antibiotics (amoxicillin and clarithomycin/metronidazole)

Question 4

How is peptic ulcer disease managed?

Answer 4

Stop NSAIDS, PPI (H2 receptor antagonist if unresponsive to PPI)

Question 5

What do prostaglandins do in the GI system?

Answer 5

Potent vasodilators, decrease acid secretion, stimulate bicarb and mucus secretion in stomach

Question 6

Describe resting vs stimulated phase of a parietal cell

Answer 6

Resting = Proton pumps are in tubovesicles 
Stimulated = tubovesicles fuse with canalicular membrane where H+ is exchanged for K+

Question 7

How do PPIs work?

Answer 7

Bind covalently to gastric H/K ATPase irreversibly and block function

Question 8

Which enzyme metabolises PPIs?

Answer 8

Cytochrom p450

Question 9

How do H2 receptor antagonists work?

Answer 9

competatively and reversibly inhibit binding of histamine to H2 receptors

Question 10

What are prostaglandins used for ?

Answer 10

treatment for NSAID induced ulcers

Question 11

What type of drug is used to treat dyspepsia?

Answer 11

Antacids

Question 12

What side effect can aluminium hydroxide cause?

Answer 12

Constipation

Question 13

What side effect can magnesium hydroxide cause?

Answer 13

Diarrhoea

Question 14

What is a successful treatment for H.pylori?

Answer 14

PPI and 2 antibiotics