reproductive Flashcards
leuprolide MOA
gnRh agnoist
ethiny estradiol MOA
Er agonist
DES MOA
ER agnoist
mestranol MOA
ER agonist
clomiphene MOA
anatg of ER at the hypothalamus
tamoxifen MOA
antag at breast
ag at bone
ag at endometrium
raloxifene MOA
antag at breast
ag at bone
antag at endometrium
anastrozole MOA
aromatase inhibitor
exemestane MOA
aromatase inhibitor
progestin MOA
progestoerone receptor agonist
mifepristone Ru-486 MOA
competitive inhibitor of progestins at the PR
terbutaline MOA
b2 agonist
ritodrine MOA
b2 agonist
danazol MOA
synthetic androgen that acts as partial agonist at androgen receptors
testosterone MOA
agonist at AR
methyltestosterone MOA
agonist at AR
finasteride MOA
inhibits 5 alpha reductase
flutamide MOA
nonsteroidal competitive inhibitor at AR
ketoconazole MOA
inhibites seroid syntheisis @ 17, 20 desmolase
spironolactone MOA
inhibites steroid binding, 17 alpha hydroxylase, 17,20 desmolase
tamsulosin MOA
alpha 1 antqagonist
sidenafil/vardenafil/tadalafil MOA
inhibit PDE5
minoxidil MOA
direct arteriolar vasodilator
uses of leuprolide
moa = GnRH agonist
pulsatile: infertility
contiuous: prostate cancer after flutamide blocks ar
continous: uterine fibroids
continuous: precocious puberty
usese of ethinyl estradiol, DES and mestranol
ER agonists
hypogonadism or ovarina gailure
menstural abrnoamlities, HRT in post menopa
men with androgen dependent prostate cancer
use of clomiphene
inhibits ER at the hypothalamus
PCOS infertility treatmetn vrs anovulation
use of tamoxifen
antag at breast
ag at bone
ag at endo
to treat and prevent ER/PR positive breast cancer
use of raloxifen
antag at breast
ag at bone
antag at end
osteoporosis
use of HRT
prevent and reliefe menopausal symptoms
osteoporosis
use of anastrozole
aromatse inhibitors
postmenopausal women wit ER positive breast cancer
used of exemestane
aromatase inhibitors
postemenopausal women with ER posirive breast cnacners
use of progestins
PR ags
UCp
endometrial cancer
abnormal uterine bleeding
use of mifepristone
competitive inhibitor of PR
termination of pregos with misoprostal
use of terbutaline
b2 agonist
decreases freqency of contractions of women in labour
use of ritodrine
b2 agonist
decreases frequency of contractions of women in labour
use of danazol
synthetic androgen with partial agonist at androgen receptors
endometriosis
herediratary angioedema
uest of testosterone and metyhltestosterone
ag at AR
hypogonadism
promotes development of secondary sex characteristics
stimulatio of anablosim to recovery after burn and injuery
use of finasteride
5a reductased inhibitor
BPH
male patterened baldness
use of flutamide
nonsteroidal competitive inhibitor of AR
prostate carcinoma wtih leuprolide
use of ketoconazole
inhibites steroid synthesis/inhibits 17,20 desmolase
treat PCOS to reduce androgenic symptoms
use of spironolactone
inhibites steroid binding, 17 OHase, 17,2 desmolase
treats PCOS to reduces andogenic symptoms
use of tamsulosin
alpha1a/d antagonist
treast BPH
use of sildenafil/v ardenafil/tadalafil
inhibits PDE5
erectile dysfunction
use of minoxidil
direct arteriolar vasodiation
androgentic alopecia
severe refractory hyertension
toxo of minoxidil
direct arterial vasodilater
androgenic alopecia
severe refractory hypertension
toxo of sildenafil/vardenafil/tadalafil
inhibties pDe5
use at erectile dysfucntion
TOXO - headache, flushing, dysepsia, cyanopsia, hypotension with nitrates
toxo of tamsulosin
alpha1a/d antag
used at BPH
no toxo listed
toxo of spironolactone
inhibit steroid binding, 17 alpha OHase, 17, 20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhoea
toxo of ketoconazole
inhibits steroid synthesis, 17,20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhea
toxo of testosterone adn methyltestosteron
ag at AT
hypogonasdism, promotes development of secondary sexual characteristics, promotes healing @ anabolism in burns and injury
toxo of danazole
synthetic androgen, partial agnoist at androgen receptorp
@ endometriosis and hereditary angioedema
TOXO - weight gain, edema, acne, hirsutisim, masculinizaiton, decreased HDL levels and HEPATOTOXICITY
hepatotosicity
danazole
toxo fo terbutaline and riodrine
beta 2 agonists uterine relax
decreased freqeuncy of uterine contractions in labour
none listed
toxo of oral conctraceptvives
increased risk of vs in smokers over 35
toxo of mifepristone RU-486
progestin receptor competitive inhibitor
termination of pregos with misoprostol/PGE1
heavy bleeding, gi effects (n/a/anorexia), abdominal pain
toxo of progestin
progestin receptor agonist, decrease grwtoh and icnreases vascularization of endom
@ oral contraceptins, endometrial cancer and abnormal uterine bleeding
toxo of anastrozole
aromatase inhibit
used for postmenopausla women with ER positive breast cancer
no toxo listed
toxo of exemestane
aromatase inhibit
used in postmenopausal women with ER positive breast coancer
no toxo listed
toxo of raloxifene
antag breast antag endo ag bone for osteoporosis increased risk of thromboembooic events
toxo of tamoxifene
antag at breast
ag at bone
ag at endo
used at ER/PR breast cancer tx and prevent
toxo - icnreasd thromboemoblic events, icnreased endometrial cancer
toxo fo clomiphene
antag of ER at hypothalamus infertility at PCOs by ovuation induction hot flashes ovarina enlargementh multiple simultaneous pregos visual disturbances
two drugs that can cause visual changes
clomiphene - hypothalalmus ER antag
sidenafil - cyanopsia inhibit PDE5
toxo of mestranol
ER agonist
hypogonadism or ovarina failure, menstrual abonromalties, HRT, men with androgen dependent prostate cancers
TOXO: increase risk of endometrial cancer, bleeding post menopausal woen, clear cella denomarcinom in vaigna, increase rick of thrmobi
where are mestranol, DES, ethinylestradiol contraindicated
Er positive breast cancer (treat with anastrozole and exemestane aromatse inhibitors)
historoy of DVT
toxo fo leuprolide
ag of GnRH
pulsatlie - infertility
continuous - precocious puberty, uterine fibroides, prostate cancer after AR blockade with flutamide
toxo: antiandrogen. n/v
