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Pharmocology - step > reproductive > Flashcards

reproductive Flashcards

1
Q

leuprolide MOA

A

gnRh agnoist

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2
Q

ethiny estradiol MOA

A

Er agonist

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3
Q

DES MOA

A

ER agnoist

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4
Q

mestranol MOA

A

ER agonist

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5
Q

clomiphene MOA

A

anatg of ER at the hypothalamus

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6
Q

tamoxifen MOA

A

antag at breast
ag at bone
ag at endometrium

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7
Q

raloxifene MOA

A

antag at breast
ag at bone
antag at endometrium

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8
Q

anastrozole MOA

A

aromatase inhibitor

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9
Q

exemestane MOA

A

aromatase inhibitor

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10
Q

progestin MOA

A

progestoerone receptor agonist

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11
Q

mifepristone Ru-486 MOA

A

competitive inhibitor of progestins at the PR

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12
Q

terbutaline MOA

A

b2 agonist

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13
Q

ritodrine MOA

A

b2 agonist

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14
Q

danazol MOA

A

synthetic androgen that acts as partial agonist at androgen receptors

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15
Q

testosterone MOA

A

agonist at AR

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16
Q

methyltestosterone MOA

A

agonist at AR

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17
Q

finasteride MOA

A

inhibits 5 alpha reductase

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18
Q

flutamide MOA

A

nonsteroidal competitive inhibitor at AR

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19
Q

ketoconazole MOA

A

inhibites seroid syntheisis @ 17, 20 desmolase

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20
Q

spironolactone MOA

A

inhibites steroid binding, 17 alpha hydroxylase, 17,20 desmolase

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21
Q

tamsulosin MOA

A

alpha 1 antqagonist

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22
Q

sidenafil/vardenafil/tadalafil MOA

A

inhibit PDE5

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23
Q

minoxidil MOA

A

direct arteriolar vasodilator

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24
Q

uses of leuprolide

A

moa = GnRH agonist

pulsatile: infertility
contiuous: prostate cancer after flutamide blocks ar
continous: uterine fibroids
continuous: precocious puberty

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25
Q

usese of ethinyl estradiol, DES and mestranol

A

ER agonists
hypogonadism or ovarina gailure
menstural abrnoamlities, HRT in post menopa
men with androgen dependent prostate cancer

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26
Q

use of clomiphene

A

inhibits ER at the hypothalamus

PCOS infertility treatmetn vrs anovulation

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27
Q

use of tamoxifen

A

antag at breast
ag at bone
ag at endo
to treat and prevent ER/PR positive breast cancer

28
Q

use of raloxifen

A

antag at breast
ag at bone
antag at end
osteoporosis

29
Q

use of HRT

A

prevent and reliefe menopausal symptoms

osteoporosis

30
Q

use of anastrozole

A

aromatse inhibitors

postmenopausal women wit ER positive breast cancer

31
Q

used of exemestane

A

aromatase inhibitors

postemenopausal women with ER posirive breast cnacners

32
Q

use of progestins

A

PR ags
UCp
endometrial cancer
abnormal uterine bleeding

33
Q

use of mifepristone

A

competitive inhibitor of PR

termination of pregos with misoprostal

34
Q

use of terbutaline

A

b2 agonist

decreases freqency of contractions of women in labour

35
Q

use of ritodrine

A

b2 agonist

decreases frequency of contractions of women in labour

36
Q

use of danazol

A

synthetic androgen with partial agonist at androgen receptors
endometriosis
herediratary angioedema

37
Q

uest of testosterone and metyhltestosterone

A

ag at AR
hypogonadism
promotes development of secondary sex characteristics
stimulatio of anablosim to recovery after burn and injuery

38
Q

use of finasteride

A

5a reductased inhibitor
BPH
male patterened baldness

39
Q

use of flutamide

A

nonsteroidal competitive inhibitor of AR

prostate carcinoma wtih leuprolide

40
Q

use of ketoconazole

A

inhibites steroid synthesis/inhibits 17,20 desmolase

treat PCOS to reduce androgenic symptoms

41
Q

use of spironolactone

A

inhibites steroid binding, 17 OHase, 17,2 desmolase

treats PCOS to reduces andogenic symptoms

42
Q

use of tamsulosin

A

alpha1a/d antagonist

treast BPH

43
Q

use of sildenafil/v ardenafil/tadalafil

A

inhibits PDE5

erectile dysfunction

44
Q

use of minoxidil

A

direct arteriolar vasodiation
androgentic alopecia
severe refractory hyertension

45
Q

toxo of minoxidil

A

direct arterial vasodilater
androgenic alopecia
severe refractory hypertension

46
Q

toxo of sildenafil/vardenafil/tadalafil

A

inhibties pDe5
use at erectile dysfucntion
TOXO - headache, flushing, dysepsia, cyanopsia, hypotension with nitrates

47
Q

toxo of tamsulosin

A

alpha1a/d antag
used at BPH
no toxo listed

48
Q

toxo of spironolactone

A

inhibit steroid binding, 17 alpha OHase, 17, 20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhoea

49
Q

toxo of ketoconazole

A

inhibits steroid synthesis, 17,20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhea

50
Q

toxo of testosterone adn methyltestosteron

A

ag at AT
hypogonasdism, promotes development of secondary sexual characteristics, promotes healing @ anabolism in burns and injury

51
Q

toxo of danazole

A

synthetic androgen, partial agnoist at androgen receptorp
@ endometriosis and hereditary angioedema
TOXO - weight gain, edema, acne, hirsutisim, masculinizaiton, decreased HDL levels and HEPATOTOXICITY

52
Q

hepatotosicity

A

danazole

53
Q

toxo fo terbutaline and riodrine

A

beta 2 agonists uterine relax
decreased freqeuncy of uterine contractions in labour
none listed

54
Q

toxo of oral conctraceptvives

A

increased risk of vs in smokers over 35

55
Q

toxo of mifepristone RU-486

A

progestin receptor competitive inhibitor
termination of pregos with misoprostol/PGE1
heavy bleeding, gi effects (n/a/anorexia), abdominal pain

56
Q

toxo of progestin

A

progestin receptor agonist, decrease grwtoh and icnreases vascularization of endom
@ oral contraceptins, endometrial cancer and abnormal uterine bleeding

57
Q

toxo of anastrozole

A

aromatase inhibit
used for postmenopausla women with ER positive breast cancer
no toxo listed

58
Q

toxo of exemestane

A

aromatase inhibit
used in postmenopausal women with ER positive breast coancer
no toxo listed

59
Q

toxo of raloxifene

A 
antag breast
antag endo
ag bone
for osteoporosis
increased risk of thromboembooic events
60
Q

toxo of tamoxifene

A

antag at breast
ag at bone
ag at endo
used at ER/PR breast cancer tx and prevent
toxo - icnreasd thromboemoblic events, icnreased endometrial cancer

61
Q

toxo fo clomiphene

A 
antag of ER at hypothalamus
infertility at PCOs by ovuation induction
hot flashes
ovarina enlargementh
multiple simultaneous pregos
visual disturbances
62
Q

two drugs that can cause visual changes

A

clomiphene - hypothalalmus ER antag

sidenafil - cyanopsia inhibit PDE5

63
Q

toxo of mestranol

A

ER agonist
hypogonadism or ovarina failure, menstrual abonromalties, HRT, men with androgen dependent prostate cancers
TOXO: increase risk of endometrial cancer, bleeding post menopausal woen, clear cella denomarcinom in vaigna, increase rick of thrmobi

64
Q

where are mestranol, DES, ethinylestradiol contraindicated

A

Er positive breast cancer (treat with anastrozole and exemestane aromatse inhibitors)
historoy of DVT

65
Q

toxo fo leuprolide

A

ag of GnRH
pulsatlie - infertility
continuous - precocious puberty, uterine fibroides, prostate cancer after AR blockade with flutamide
toxo: antiandrogen. n/v

Pharmocology - step (16 decks)

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