reproductive Flashcards
1
Q
leuprolide MOA
A
gnRh agnoist
2
Q
ethiny estradiol MOA
A
Er agonist
3
Q
DES MOA
A
ER agnoist
4
Q
mestranol MOA
A
ER agonist
5
Q
clomiphene MOA
A
anatg of ER at the hypothalamus
6
Q
tamoxifen MOA
A
antag at breast
ag at bone
ag at endometrium
7
Q
raloxifene MOA
A
antag at breast
ag at bone
antag at endometrium
8
Q
anastrozole MOA
A
aromatase inhibitor
9
Q
exemestane MOA
A
aromatase inhibitor
10
Q
progestin MOA
A
progestoerone receptor agonist
11
Q
mifepristone Ru-486 MOA
A
competitive inhibitor of progestins at the PR
12
Q
terbutaline MOA
A
b2 agonist
13
Q
ritodrine MOA
A
b2 agonist
14
Q
danazol MOA
A
synthetic androgen that acts as partial agonist at androgen receptors
15
Q
testosterone MOA
A
agonist at AR
16
Q
methyltestosterone MOA
A
agonist at AR
17
Q
finasteride MOA
A
inhibits 5 alpha reductase
18
Q
flutamide MOA
A
nonsteroidal competitive inhibitor at AR
19
Q
ketoconazole MOA
A
inhibites seroid syntheisis @ 17, 20 desmolase
20
Q
spironolactone MOA
A
inhibites steroid binding, 17 alpha hydroxylase, 17,20 desmolase
21
Q
tamsulosin MOA
A
alpha 1 antqagonist
22
Q
sidenafil/vardenafil/tadalafil MOA
A
inhibit PDE5
23
Q
minoxidil MOA
A
direct arteriolar vasodilator
24
Q
uses of leuprolide
A
moa = GnRH agonist
pulsatile: infertility
contiuous: prostate cancer after flutamide blocks ar
continous: uterine fibroids
continuous: precocious puberty
25
usese of ethinyl estradiol, DES and mestranol
ER agonists
hypogonadism or ovarina gailure
menstural abrnoamlities, HRT in post menopa
men with androgen dependent prostate cancer
26
use of clomiphene
inhibits ER at the hypothalamus
| PCOS infertility treatmetn vrs anovulation
27
use of tamoxifen
antag at breast
ag at bone
ag at endo
to treat and prevent ER/PR positive breast cancer
28
use of raloxifen
antag at breast
ag at bone
antag at end
osteoporosis
29
use of HRT
prevent and reliefe menopausal symptoms
| osteoporosis
30
use of anastrozole
aromatse inhibitors
| postmenopausal women wit ER positive breast cancer
31
used of exemestane
aromatase inhibitors
| postemenopausal women with ER posirive breast cnacners
32
use of progestins
PR ags
UCp
endometrial cancer
abnormal uterine bleeding
33
use of mifepristone
competitive inhibitor of PR
| termination of pregos with misoprostal
34
use of terbutaline
b2 agonist
| decreases freqency of contractions of women in labour
35
use of ritodrine
b2 agonist
| decreases frequency of contractions of women in labour
36
use of danazol
synthetic androgen with partial agonist at androgen receptors
endometriosis
herediratary angioedema
37
uest of testosterone and metyhltestosterone
ag at AR
hypogonadism
promotes development of secondary sex characteristics
stimulatio of anablosim to recovery after burn and injuery
38
use of finasteride
5a reductased inhibitor
BPH
male patterened baldness
39
use of flutamide
nonsteroidal competitive inhibitor of AR
| prostate carcinoma wtih leuprolide
40
use of ketoconazole
inhibites steroid synthesis/inhibits 17,20 desmolase
| treat PCOS to reduce androgenic symptoms
41
use of spironolactone
inhibites steroid binding, 17 OHase, 17,2 desmolase
| treats PCOS to reduces andogenic symptoms
42
use of tamsulosin
alpha1a/d antagonist
| treast BPH
43
use of sildenafil/v ardenafil/tadalafil
inhibits PDE5
| erectile dysfunction
44
use of minoxidil
direct arteriolar vasodiation
androgentic alopecia
severe refractory hyertension
45
toxo of minoxidil
direct arterial vasodilater
androgenic alopecia
severe refractory hypertension
46
toxo of sildenafil/vardenafil/tadalafil
inhibties pDe5
use at erectile dysfucntion
TOXO - headache, flushing, dysepsia, cyanopsia, hypotension with nitrates
47
toxo of tamsulosin
alpha1a/d antag
used at BPH
no toxo listed
48
toxo of spironolactone
inhibit steroid binding, 17 alpha OHase, 17, 20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhoea
49
toxo of ketoconazole
inhibits steroid synthesis, 17,20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhea
50
toxo of testosterone adn methyltestosteron
ag at AT
hypogonasdism, promotes development of secondary sexual characteristics, promotes healing @ anabolism in burns and injury
51
toxo of danazole
synthetic androgen, partial agnoist at androgen receptorp
@ endometriosis and hereditary angioedema
TOXO - weight gain, edema, acne, hirsutisim, masculinizaiton, decreased HDL levels and HEPATOTOXICITY
52
hepatotosicity
danazole
53
toxo fo terbutaline and riodrine
beta 2 agonists uterine relax
decreased freqeuncy of uterine contractions in labour
none listed
54
toxo of oral conctraceptvives
increased risk of vs in smokers over 35
55
toxo of mifepristone RU-486
progestin receptor competitive inhibitor
termination of pregos with misoprostol/PGE1
heavy bleeding, gi effects (n/a/anorexia), abdominal pain
56
toxo of progestin
progestin receptor agonist, decrease grwtoh and icnreases vascularization of endom
@ oral contraceptins, endometrial cancer and abnormal uterine bleeding
57
toxo of anastrozole
aromatase inhibit
used for postmenopausla women with ER positive breast cancer
no toxo listed
58
toxo of exemestane
aromatase inhibit
used in postmenopausal women with ER positive breast coancer
no toxo listed
59
toxo of raloxifene
```
antag breast
antag endo
ag bone
for osteoporosis
increased risk of thromboembooic events
```
60
toxo of tamoxifene
antag at breast
ag at bone
ag at endo
used at ER/PR breast cancer tx and prevent
toxo - icnreasd thromboemoblic events, icnreased endometrial cancer
61
toxo fo clomiphene
```
antag of ER at hypothalamus
infertility at PCOs by ovuation induction
hot flashes
ovarina enlargementh
multiple simultaneous pregos
visual disturbances
```
62
two drugs that can cause visual changes
clomiphene - hypothalalmus ER antag
| sidenafil - cyanopsia inhibit PDE5
63
toxo of mestranol
ER agonist
hypogonadism or ovarina failure, menstrual abonromalties, HRT, men with androgen dependent prostate cancers
TOXO: increase risk of endometrial cancer, bleeding post menopausal woen, clear cella denomarcinom in vaigna, increase rick of thrmobi
64
where are mestranol, DES, ethinylestradiol contraindicated
Er positive breast cancer (treat with anastrozole and exemestane aromatse inhibitors)
historoy of DVT
65
toxo fo leuprolide
ag of GnRH
pulsatlie - infertility
continuous - precocious puberty, uterine fibroides, prostate cancer after AR blockade with flutamide
toxo: antiandrogen. n/v
