myco/fungi/scabies/helmninth Flashcards
prophylaxis for mycobacterium tuberculosis
isoniazid
treatment of mycobacterium tuberculosis
RIPE rifampin isoniazid pyrazinamide ethambutol
prophylaxis of mycobacterium avium-intracellulare
azithromycin
rifabutin
treatment for mycobacterium avium-intracellulare
azithromycin or clarithyromycin and ehtambutol
can add rifabutin or ciprofloxacin
azithromycin/clathrithromycin and ethambutol and can add rifabutin or ciprofloxacin for?
treatment for mycobacterium avium-intracellulare
treatment fo mycobacterium leprae - tuberculoid form
long term with dapson and rimapine
treatment of mycobacterium leprae - lepromatous form
dapsone, rifampin, clofazimine
treat ? with this: dapson, rifampine, clofazimine
mycobacterium leprae
what is the MOA of rifampin and rifabutin
inhibit DNA dependent RNA polymerase
what antimycobacterial drugs inhibit DNA dependent RNA polymerase
rifampin and rifabutin
what is the clinical use of rifampin and rifabutin?
m TB
delay resistance to dapson @ M leprae
meningococcal prolylaxis and chemoprophylaxis in contacts of children with HIB
toxo of rifampin and rifabutin
minor hepatotoxicity and increases P450
orang body fluids
which rifamycin is preferred in HIV patients and why
rifabutin bc stimulates cytochrome P450 less
what is the mechanism of resistance of rifampin and rifabutin
mutationed reduces drug binding to RNA polymerase
monotherapy - increased resistance
what are rifampins FOUR Rs?
RNA polymerase inhibitor
ramps up microsomal cytP450
red/orange body fluids
rapid resistance if used alone
what is the MOA of isoniazid
decreases synthesis of mycolic acids
bacterial catalase peroxidase encoded by KatG is needed to activate to its active metabolie
what is isoniazid used for
m TB
ONLY antimycobacterial that can be used on its own
what are the toxicities of isoniazid
neurotoxicity - can prevent with B6
hepatotoxicity
what is the mechanism of resistance of isoniazid
mutations that lead to underexpression of KatG
how can you decrease the neurotoxicity of isoniazid
give em B6
what is the MOA of pyrazinamde
unknown
what is the cxl use of pyrazinamide
M Tb
what are the a/se of pyrazinamde
hyperuricemia
hepatotoxcity
what is the MOA of ethambutol
decreases carbohydrate polymerization of mycobacterium cell wall by blocking arabinosyltransferase
what is cilinical sue of ethambutol
m TB and with azithromycin/clarithromycin for MAC (Can add rifabutin or ciprofloxacin)
a/se of ethambutol please
optic neurpathy - red gree colour blindness
what is the MOA of amphotericin B
binds ergosterol to form membrane pores that allow electrolytes through
clinical use of amphotericin B
serious systemic mycoses
treat Cryptococcus meningitis!
amphotericin B and flucytosine
treat systemic blastomyces, cocciodies, histoplasma, candida please
amphotericin B
treat serious mucor!
amphotericin B
what do you need to supplement treatment of amphotericin B with
potassium and magnesium - altered renal tubule permeability