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Pharmocology - step > Psychiatry > Flashcards

Psychiatry Flashcards

1
Q

DOC @ ADHD

A

stimulants

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2
Q

DOC @ OH withdrawal

A

long acting benzos

chlordiazeoxide, lorazepma, diazepam

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3
Q

DOC @ bipolar

A

litiuim, valproid acid, atypical antypsychotics ( olanzapine, clozapine, queitapine, risperidone, aripiprazole, ziprasidone)

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4
Q

DOC @ bulimia

A

SSRI ( fluoxetine, paroxetine, sertraline, citalopram)

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5
Q

DOC @ depression

A

SSRI (fluoxetine, paroxetine, sertraline, citalopram)

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6
Q

DOC @ GAD

A

SSRI (fluoxetine, paroxetine, sertraline, citalopram)
SNRI (venlafaxine, duloxetine)
busprion

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7
Q

DOC @ schizophrenia

A 
atypical antipsychotics (haloperidol, trifluoperazine, flupenazine, thioridazine, chlorpromazine)
-AZINES
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8
Q

DOC @ social phobias

A

SSRIs (fluoxetine, paroxetine, sertraline, citalopram)

beta blockers

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9
Q

DOC @ OCD

A

SSRIs (fluoxetine, paroxetine, sertraline, citalopram)

clomipramine (TCA)

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10
Q

DOC @ panic disorder

A

SSRI (fluoxetine, paroxetine, sertraline, citalopram)
venlafaxine (SNRI)
benzodiazepines

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11
Q

DOC @ PTSD

A

SSRI (fluoxetine, paroxetine, sertraline, citalopram)

venlafaxine (SNRI)

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12
Q

DOC @ Tourette syndrome

A

antipsychtics (fluphenazien, pimozide)

tertrabenazine

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13
Q

uses of methylphenidate, destroamphetamine methamphetamie

A

ADHD
narcolepsy
appetite stimulant

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14
Q

increased NE and DA especially used for ADHD

A

CNS stimulatns

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15
Q

increses NE and DA

A

CNS stimulants

buproprion

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16
Q

list the typicl antipsychotics

A 
haloperisol
trifluoperazine
fluphenazine
thioridazine
chlorpromazine
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17
Q

moa of typical antipsychotics

A

block D2 – increase cAMP

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18
Q

uses of typical antipsychotics

A

positive symptoms of schizophrena
psychosis
acute mania
Tourette syndrome

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19
Q

high potency typical antipsychotics please

A

haloperidol
trifluoperazine
fluphenazine
TRY to FLY High

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20
Q

low potency typical antipsychotics please

A

chlorpromazine

thioridazine

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21
Q

a/se of typical antipsychotics in general

A 
EPS
endocrine - hyperprolacti
anticholi - dry mouth, constipation
antiadrena1 - hypotension
antihista - sedation
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22
Q

what can cause QT prolongation

A

typical antipsychotics
atypical antipsychotics
TCAs

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23
Q

what s/e with haloperidol

A

EPS
Neurleptic malignant syndrome
tardive dyskinesia

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24
Q

what s/e with trifluoperazine and fluphenazine

A

eps - huntingot, delirium,

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25
Q

what s/e with chlorpormazine

A

anti choli
anti alpha 1
anti histamine
corneal deposits

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26
Q

what s/e with thioridazine

A

anti choli
anti alpha 1
anti histamine
retinal deposits

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27
Q

rigidity
Myoglobinuria
autonomic instability
hyperpyreia

A

neuroleptic malignany syndrome

haloperidol

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28
Q

how do you treat rigidity/Myoglobinuria/autonomic instability/hyperpyrexia with haloperid use

A

dantrolene

D2 agonists - bromocriptin

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29
Q

descrien the evolution of EPS sides efects

A

4 hours acute dystonia (muscle spasm, stiffness, oculogyric crisis)
4 day akathisia/restlessness
4 week bradykinesia/parkinsonism
4 month tardive dyskinesia

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30
Q

symptoms of neuroleptic malignancy syndrome

A 
ridigity, Myoglobinuria, autonomic instability, hyperpyrexia
treat with dantrolene and D2 agonist ie bromocription
FEVER
fever
encephalopathy
vitals unstable
enzymes increase d(muscle)
rigidity of muscles
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31
Q

how do you treat the extrapyramidal system side effects of high potentncy typical antipsychotis

A

haloperidol, trifluoperazine, fluphenazie

BENZTROPINE and DIPHENHYDRAMIE

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32
Q

used of benztropine and diphenhydramine

A

eps symptoms of high potency typical antipsychotics

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33
Q

list the atypical antipsychotics please

A

olanzapine, clozapine, quetiapine
resperidone
aripiprazole, ziprasidone

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34
Q

MOA of atypical antipsychotics please

A

not completely udnerstonnd

varied at 5HT2, dopamine, H1 and Ne receptors

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35
Q

use of atypical antipsychotics please

A 
positive and negative schizophrenia
bipolar
OCD
anxiety
tourettes
depression
mania
36
Q

how do s/e between typical and atypical antipsychotics vary

A

less eps and anticholis in atypical

37
Q

s/ae of clozapine please

A

AGRANULOCYTOSIS, weight gain, seizure

38
Q

a/se of olanzapine please

A

weight gain

39
Q

a/se of resiperidone

A

increased prolactin
lactatin, gynecomastia
irregular menstratuion
fertility issues

40
Q

a/se of all atypical antipscyhotics

A

QT prolongation

41
Q

what is moa of lithium

A

not really known

inhibit of phosphoinositol cascaise

42
Q

use of lithium

A

SIADH (wherease SSRi cause)
mood stabilized for bipolar
blocks relapse and acute main

43
Q

a/se of lithium

A 
tremor
hypothyroidism
ebstein anomaly in pregos
nephrogenic diabetes insipidius
kidney
44
Q

what do you use in lithium toxocity

45
Q

moa of busprion

A

stimulats 5HT1a

46
Q

use of busprion

A

GAD (alsoSSRi and SNRI)

47
Q

benefits of busprion

A

no addiction, tolerance, sedation

no interaction with OH (barbiturates and benzos do)

48
Q

list the SSRIs please

A

fluoxetine
paroxetine
sertraline
citalopram

49
Q

MOA of SSRIs please

A

5ht reuptake inhibitors

50
Q

used of SSRI

A 
depression
GAD
panic disorder
OCD
bulimia
social phobias
PTSD
51
Q

a/se of SSRI

A 
serotonin syndrome (Ssri, snri, tca, maoi, meeperidine, )
gi distress
sexual dysfunction - anorgasmia, decreased libido
52
Q 
hyperthermia
confusion
myoclonus
cardiovascular instability
flushing
diarrhoea
seizures
A

serotonin syndrome

53
Q

how to treat serotonin syndrome

A

cyproheptadine a 5HT2 antag

54
Q

sxs fo serotonin syndrome

A 
hyperthermia
confusion
myoclonus
cardiovascular instability
flushing 
diarrhoea
seizures
55
Q

lsit the snris please

A

venlafaxine, duloxetine

56
Q

diabetic peripheral neupahty

A

duloxetine

57
Q

moa of snris

A

inhibit Ne and 5Ht reuptake

58
Q

ase of SNRIs

A

increased bp most common
stimulant effects
sedation
nausea

59
Q

useds of venlafaxine

A

depression, GAD, panic disorder, PTSD

60
Q

list the tcas please

A

amitriptyline, nortriptyline
imipramine, desipramiine, clomipramine
doxepin, amoxapine

61
Q

moa of tca

A

block reuptae of Ne and 5ht

62
Q

uses of tca

A 
major depression 
ocd - clomipramine
peripheral neuropathy
chronic pain
migraine prophylaxis
63
Q

migraine prophylaxis

64
Q

chronic pain

65
Q

a/se of tcas

A

anti alpha 1
anti chloi
prolongation of qt itnerval

66
Q

tca to use in elderly and why

A

nortriptyline bc less anticholis that would cause confusion and halluciations

67
Q

how to prevent arrhythmia with tca use

68
Q

serious a/se of tcas

A

coma
convulsions
cardiotoxicity
resp depression

69
Q

NaHCO3

A

prevent arrhythmias in TCAs

70
Q

list the MAOis please

A 
MAO takes pride in changhai
tranylcypromine
phenelzine
isocarboxazid
selegiline
71
Q

how is selegiline diff

A

selevite MAO B inhibitor

72
Q

what is the moa of maois?

A

nonselectie MAO inhibition increases amine NT ie Ne, 5Ht, and Da

73
Q

uses of MAOis

A

atypical depression

anxiety

74
Q

a/se of maois

A

hypertensive crisis with tyramine

CNS stimulation

75
Q

contraindicated at maois

A

cheese and wine - hypertensive crisis

serotonin syndrome - ssri, tca, st johsn wart, meperidine, dextromethorphan

76
Q

use of buproprion

A

smoking cessation

77
Q

moa of buproprion

A

increase ne and da with unknown moa

78
Q

a/se of buproprion

A

stimulatnt - tach and insomnia
headache
seizures in anorexic/bulimic patients

79
Q

what is buproprion godo for

A

no sexy time effects

80
Q

moa of mirtazapine

A

inhibits alpha 2 – increase Ne and 5HT release

5Ht2 and 5HT3 inhibitiors

81
Q

uses of miertazapine

A

depression - want to sleep bc causes sedation

weight gain in elderly or anorexix (also causes increased appetite)

82
Q

a/se fo miertazapine

A

sedation
weight gain
increased appetite
dry mouth

83
Q

what is trazodone known for

84
Q

moa of trazodone

A

blocsk 5HT2 and alpha 1

85
Q

what is trazodone used for

86
Q

a/se of trazodone

A

priapism
sedation
nausea
postural hypotension

Pharmocology - step (16 decks)

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