msk, skin, ct - last one eeekkkk!!

Question 1

function fo LTC4 D4 and E4

Answer 1

increases bronchial tone

Question 2

function fo LTB4

Answer 2

PMN chemo

Question 3

function fo PGI2

Answer 3

decrease platelet aggregation

decrease vascular tone

Question 4

function of PGE1

Answer 4

decreas vascular tone

Question 5

function of PGE2

Answer 5

increases uterine tone

Question 6

function fo PGF2

Answer 6

increases uterine tone

Question 7

function of thromboxane A2

Answer 7

increases platelet aggregation

increases vascular tone

Question 8

moa acetaminophen

Answer 8

reversibly inhibits cox, mostly in cns

inactivated peripherally

Question 9

cx use of acetaminophen

Answer 9

antipyretic
analgesic
not anti inflammatory
children with viral infection to avoid reyes syndrome

Question 10

toxo of acetaminophen

Answer 10

o/s = hepatic necrosis and NAPQI uses up all the glutathion and causes toxic tissue byproducts in the liver

Question 11

antidote fo acetaminophene o/d

Answer 11

NAC - regenerates glutathione

Question 12

moa aspirin

Answer 12

irreversibly linhibits cyclooxyngease one and two via acetylation - decrease txa2 and pgs
increase bleeding time (no change to pt and ptt)

Question 13

low dose of aspirin?

Answer 13

<300 = platelet inhibit aggregation

causes secretion fo uric acid

Question 14

intermediate dose of aspirin?

Answer 14

300-2400 = antipyretic and analgesic

Question 15

high does aspirin?

Answer 15

2400-4000 = antiinflammatory

reabsorption of uric acid weakly

Question 16

toxo of aspirin

Answer 16

tinnitus

gi ulceration

Question 17

chornic used of aspirin?

Answer 17

acute renal failure, interstitial nephtiritis, gi bleeding

Question 18

children with aspiring

Answer 18

not in viral infections unless you want to stupor/coma/hepatic encephalopathy them up

Question 19

acid base balance with aspring

Answer 19

first - respiratory alkalaosis
progresses - mixed metabolic acidodid resp alkalaossi
used the formulat to see if compensated….somethting liek 1.5 HCO3 + /-??? LOOK UP BAH darn.

Question 20

moa celecoxib

Answer 20

reversibly inhibits COS2

Question 21

where is cox 2 found

Answer 21

inflammatory cells
vascular endothelium
mediates inflammation and pian

Question 22

what does cox1 do?

Answer 22

helps maintain gastric mucosa

Question 23

benefit of celecoxib

Answer 23

no corrosive effet like other nsaids on the gi liking

spared paltelet function as txa2 is dependent on COX1

Question 24

clinical use fo celecoxib

Answer 24

RA and OA

Question 25

treat RA and OA

Answer 25

celecoxib

Question 26

toxo of celecoxib

Answer 26

sulfa | thrombotic event risk increase

Question 27

list the nsaids

Answer 27

``` ibuprofen naproxen diclofenace indomethacin ketorolac ```

Question 28

moa of nsaids

Answer 28

reversibly inhibit cox 1 and 2. block pg synthesis

Question 29

use of msaids

Answer 29

antipyretic, analgesic, antiinflammatory

Question 30

what is indomethacin used for

Answer 30

closign a pda

Question 31

a/se of nsaids please

Answer 31

interstitial nephritis gastric ulcer renal iscehmia - pgs vasodilate afferent arteriole

Question 32

what are bisphosphonates

Answer 32

DRONTES | alendronate

Question 33

moa of dronates

Answer 33

bisphosphonates | pyrophosphate analougs that bind hydroxyapatite in bone and inhibit osteoclast activity

Question 34

use of dronates

Answer 34

osteoporposis hypercalcemia paget disease of bone

Question 35

treat hypercalcemia

Answer 35

dronate/bisphosphonates

Question 36

treat pagets disease

Answer 36

dronates

Question 37

what is teriparatide

Answer 37

recombinant PTH analog given subcutaneously daily | icnreased osteoblastic activity

Question 38

use of teriparatide

Answer 38

osteoproosis - causes increased boen growth vrs antiresorptive threaphy cough cough bisphosphonates

Question 39

toxo of teriparatide

Answer 39

transient hypercalcemia | increased risk of osteosarcomas (seen in rodents)

Question 40

drug associated potentially with icnreased risk of osteosarcoma?

Answer 40

teriparatide

Question 41

list the drugs used for chronic gout as preventative tx

Answer 41

allopurinol febuxostat pegloticase probenecid

Question 42

moa fo allopurinol

Answer 42

inhibites xanthine oxisase after being converted to alloxanthing decrease conversion fo xanthine to uric acid

Question 43

cxl use of allopurinol outside of preventative in chronci gout

Answer 43

luekemia and lymphoma to prevent tumor lysis associated urate neprhotpahty

Question 44

what drugs shoudl be of concern when treating simultaenously with allopurinol

Answer 44

azothioprine and 6 MP = will be icnreased bc both are normally metabolized by xanthine oxidase

Question 45

what is febuxostat

Answer 45

inhibits xanthine oxidase | preventative gout

Question 46

what is pegloticase

Answer 46

recombinant uricase that catalyzes metabolism or uric acid to allantoin - more water soluble

Question 47

what is probenecid

Answer 47

inhibits reabsorption of uric acid in proximal covoluted tublue - also inhibtis secretino of penicillin

Question 48

a/se of probenecid

Answer 48

can ppt uric acid calculi

Question 49

tx for acute gout pelase list all

Answer 49

nsaids, glucocorticoids and colchicine

Question 50

which nsaids are use for acute gout

Answer 50

naproxen | indomethacin

Question 51

how are glucocorticoids used for acute gout

Answer 51

oral or intra-articular

Question 52

what is colchicine?

Answer 52

binds and stablized tubulin to inhibit mt polymerization impairing PMN chemotaxis and degranulation

Question 53

a/se of colchicine

Answer 53

gi side effects

Question 54

use of colchicine

Answer 54

acute and prophylactic gout

Question 55

what drugs should be avoided in gout treatmetn?

Answer 55

salicylates - all but the highest doses depress uric acid clearance so even high doese have only minor uricosuric acitivy

Question 56

what are a/se of TNFa inhibitos

Answer 56

predispose to infection includign reactivation of latent TB

Question 57

why do you have to worry abotu TB with TNFa inhibitors

Answer 57

bc TNFa promotes granuloma formation and stabilization

Question 58

what is etaneracept

Answer 58

TNFa IgG1 Fc fusion protein made by recombinat DNA | aka decoy receptor for TNFa

Question 59

what do you use etaneracept for

Answer 59

RA, ankylosing, psoriais

Question 60

what are infliximab and adalimumab?

Answer 60

anti TNFA monoclona abts

Question 61

uses of infliximab abd adalimumab

Answer 61

the seronegs and RA instead of reactive/reiters | IBD, psoriasis, ankylosing,