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Pharmocology - step > msk, skin, ct - last one eeekkkk!! > Flashcards

msk, skin, ct - last one eeekkkk!! Flashcards

1
Q

function fo LTC4 D4 and E4

A

increases bronchial tone

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2
Q

function fo LTB4

A

PMN chemo

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3
Q

function fo PGI2

A

decrease platelet aggregation

decrease vascular tone

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4
Q

function of PGE1

A

decreas vascular tone

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5
Q

function of PGE2

A

increases uterine tone

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6
Q

function fo PGF2

A

increases uterine tone

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7
Q

function of thromboxane A2

A

increases platelet aggregation

increases vascular tone

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8
Q

moa acetaminophen

A

reversibly inhibits cox, mostly in cns

inactivated peripherally

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9
Q

cx use of acetaminophen

A

antipyretic
analgesic
not anti inflammatory
children with viral infection to avoid reyes syndrome

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10
Q

toxo of acetaminophen

A

o/s = hepatic necrosis and NAPQI uses up all the glutathion and causes toxic tissue byproducts in the liver

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11
Q

antidote fo acetaminophene o/d

A

NAC - regenerates glutathione

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12
Q

moa aspirin

A

irreversibly linhibits cyclooxyngease one and two via acetylation - decrease txa2 and pgs
increase bleeding time (no change to pt and ptt)

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13
Q

low dose of aspirin?

A

<300 = platelet inhibit aggregation

causes secretion fo uric acid

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14
Q

intermediate dose of aspirin?

A

300-2400 = antipyretic and analgesic

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15
Q

high does aspirin?

A

2400-4000 = antiinflammatory

reabsorption of uric acid weakly

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16
Q

toxo of aspirin

A

tinnitus

gi ulceration

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17
Q

chornic used of aspirin?

A

acute renal failure, interstitial nephtiritis, gi bleeding

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18
Q

children with aspiring

A

not in viral infections unless you want to stupor/coma/hepatic encephalopathy them up

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19
Q

acid base balance with aspring

A

first - respiratory alkalaosis
progresses - mixed metabolic acidodid resp alkalaossi
used the formulat to see if compensated….somethting liek 1.5 HCO3 + /-??? LOOK UP BAH darn.

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20
Q

moa celecoxib

A

reversibly inhibits COS2

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21
Q

where is cox 2 found

A

inflammatory cells
vascular endothelium
mediates inflammation and pian

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22
Q

what does cox1 do?

A

helps maintain gastric mucosa

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23
Q

benefit of celecoxib

A

no corrosive effet like other nsaids on the gi liking

spared paltelet function as txa2 is dependent on COX1

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24
Q

clinical use fo celecoxib

A

RA and OA

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25
Q

treat RA and OA

A

celecoxib

26
Q

toxo of celecoxib

A

sulfa

thrombotic event risk increase

27
Q

list the nsaids

A 
ibuprofen
naproxen
diclofenace
indomethacin
ketorolac
28
Q

moa of nsaids

A

reversibly inhibit cox 1 and 2. block pg synthesis

29
Q

use of msaids

A

antipyretic, analgesic, antiinflammatory

30
Q

what is indomethacin used for

A

closign a pda

31
Q

a/se of nsaids please

A

interstitial nephritis
gastric ulcer
renal iscehmia - pgs vasodilate afferent arteriole

32
Q

what are bisphosphonates

A

DRONTES

alendronate

33
Q

moa of dronates

A

bisphosphonates

pyrophosphate analougs that bind hydroxyapatite in bone and inhibit osteoclast activity

34
Q

use of dronates

A

osteoporposis
hypercalcemia
paget disease of bone

35
Q

treat hypercalcemia

A

dronate/bisphosphonates

36
Q

treat pagets disease

A

dronates

37
Q

what is teriparatide

A

recombinant PTH analog given subcutaneously daily

icnreased osteoblastic activity

38
Q

use of teriparatide

A

osteoproosis - causes increased boen growth vrs antiresorptive threaphy cough cough bisphosphonates

39
Q

toxo of teriparatide

A

transient hypercalcemia

increased risk of osteosarcomas (seen in rodents)

40
Q

drug associated potentially with icnreased risk of osteosarcoma?

A

teriparatide

41
Q

list the drugs used for chronic gout as preventative tx

A

allopurinol
febuxostat
pegloticase
probenecid

42
Q

moa fo allopurinol

A

inhibites xanthine oxisase after being converted to alloxanthing
decrease conversion fo xanthine to uric acid

43
Q

cxl use of allopurinol outside of preventative in chronci gout

A

luekemia and lymphoma to prevent tumor lysis associated urate neprhotpahty

44
Q

what drugs shoudl be of concern when treating simultaenously with allopurinol

A

azothioprine and 6 MP = will be icnreased bc both are normally metabolized by xanthine oxidase

45
Q

what is febuxostat

A

inhibits xanthine oxidase

preventative gout

46
Q

what is pegloticase

A

recombinant uricase that catalyzes metabolism or uric acid to allantoin - more water soluble

47
Q

what is probenecid

A

inhibits reabsorption of uric acid in proximal covoluted tublue - also inhibtis secretino of penicillin

48
Q

a/se of probenecid

A

can ppt uric acid calculi

49
Q

tx for acute gout pelase list all

A

nsaids, glucocorticoids and colchicine

50
Q

which nsaids are use for acute gout

A

naproxen

indomethacin

51
Q

how are glucocorticoids used for acute gout

A

oral or intra-articular

52
Q

what is colchicine?

A

binds and stablized tubulin to inhibit mt polymerization impairing PMN chemotaxis and degranulation

53
Q

a/se of colchicine

A

gi side effects

54
Q

use of colchicine

A

acute and prophylactic gout

55
Q

what drugs should be avoided in gout treatmetn?

A

salicylates - all but the highest doses depress uric acid clearance so even high doese have only minor uricosuric acitivy

56
Q

what are a/se of TNFa inhibitos

A

predispose to infection includign reactivation of latent TB

57
Q

why do you have to worry abotu TB with TNFa inhibitors

A

bc TNFa promotes granuloma formation and stabilization

58
Q

what is etaneracept

A

TNFa IgG1 Fc fusion protein made by recombinat DNA

aka decoy receptor for TNFa

59
Q

what do you use etaneracept for

A

RA, ankylosing, psoriais

60
Q

what are infliximab and adalimumab?

A

anti TNFA monoclona abts

61
Q

uses of infliximab abd adalimumab

A

the seronegs and RA instead of reactive/reiters

IBD, psoriasis, ankylosing,

Pharmocology - step (16 decks)

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