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Pharmocology - step > Drug toxicity and a/se > Flashcards

Drug toxicity and a/se Flashcards

1
Q

coronary vasospasm

A

cocain, suatriptan, ergot alkaloids

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2
Q

cutaneous flushing

A

vancomycin, adenosime, niacin, CCB

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3
Q

dilated cardiomyopathy

A

doxorubicin, daunorubicin

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4
Q

torsades de poitnes

A

class III, class Ia, macrolide antibiotics, antipsychotics, TCAs

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5
Q

adrenocortical insufficiency

A

secondary to glucocorticoid withdrawl

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6
Q

hot flashes

A

tamoxifen, clomiphene

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7
Q

hyperglycemia

A

tacrolimus, protease inhibitors, niacin MCTZ, coricosteroids

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8
Q

hypthyroidism

A

lithium, amiodarne, sulfonamides

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9
Q

acute cholestatic hepatitis jaundice

A

erythromycin

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10
Q

diarrhoea

A

metforim, erythromycin, colchicine, orlistate, acarbose

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11
Q

focal to massive hepatic necrosis

A

halothane, amanita phalloides, acetaminophen, calporic acid

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12
Q

hepatitis

A

rifampin, isoniazind, pyrazinamide, statins, fibrates

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13
Q

pancreatitis

A

alcohol, azathioprine, didanosine, corticosteroids, valproic acid, furosemide, HCTZ

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14
Q

agranulocytosis

A

ganciclovir, clozapine, colchicine, carbamazepine, methimazole, propylthiouracil

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15
Q

aplastic anaemia

A

benzene, NSAIDs, chloramphenicol, carbamazepine, methimazole, propylthiouracil

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16
Q

direct coombs positive anaemia

A

methyldopa, penicillin

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17
Q

gray baby syndrome

A

chloramphenicol

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18
Q

hemolysis in G6PD deficiency

A

isoniazid, sulfonamides, dapson, primaquine, aspirin, ibuprofen, bitrfurantoin

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19
Q

megaloblastic anaemia

A

phenytoin, methotrexate, sulfa drugs

20
Q

thrombocytopenia

21
Q

thrombotic complicatiosn

22
Q

fat redistribution

A

protease inhibitiors, corticosteroids

23
Q

gingival hyperplasi

A

phenytoin, CCB, cyclosporine

24
Q

hypuricemia

A

thiazides, furosemide, pyrazinamide, niacin, cyclosporine

25
Q

myopathy

A

colchicine, fibrates, glucocorticoids ,hydroxychloroquine, IFNa, niacin, penicillamine, statins

26
Q

osteoporosis

A

corticosteroids, heparin

27
Q

photosensitivity

A

seulfonamides, amiodarone, tetracyclines, 5-FU

28
Q

steven-johnson syndrome

A

antiepileptic, allopurinol, sulfa, penicillin

29
Q

SLE-like syndrome

A

sulfa drugs, hydralazine, isoniazis, procainamide, phenytoin, etanercept

30
Q

teeth discolouration

A

tetracyclines

31
Q

tendonitis, tendon reupture, cartilage damage

A

fluoroquinolones

32
Q

cinchonism

A

quinidine, quinine

33
Q

Parkinson-like syndrome

A

antipsychotics, reserpine, metoclopramide

34
Q

seizures

A

isoniazid/vit B6 def, bupropion, imipenum/cilastatin, enflurane

35
Q

tardive dyskinesia

A

antipsychotics, metoclopramide

36
Q

diabetes insipidus

A

lithium, demeclocycline

37
Q

fanconi syndrome

A

expired tetracycline

38
Q

hemorrhagic cystistis

A

cyclophosphamide, ifosfamide

39
Q

interstitial nephritis

A

methicillin, NSAIs, furosemide

40
Q

SIADH

A

carbamazepine, cyclophosphamide, SSRIs

41
Q

dry cough

A

ACE inhibitors

42
Q

pulmonary fiboriss

A

bleomycin, busulfan, amiodarone, methotrexate

43
Q

antimuscarinic

A

atropine, TCA, antipsychoitcs, H1 blockers

44
Q

disulfiram like reactin

A

my cereal goes snap pop: metronisazole, cephalosporins, grisefulvin, procarbazine, fist gen sulfonylureas

45
Q

nephrotoxicity, ototoxicity

A

aminoglycosides, vancomycin, loops, cisplastin (may respond to amifostine)

Pharmocology - step (16 decks)

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