Drug toxicity and a/se Flashcards
coronary vasospasm
cocain, suatriptan, ergot alkaloids
cutaneous flushing
vancomycin, adenosime, niacin, CCB
dilated cardiomyopathy
doxorubicin, daunorubicin
torsades de poitnes
class III, class Ia, macrolide antibiotics, antipsychotics, TCAs
adrenocortical insufficiency
secondary to glucocorticoid withdrawl
hot flashes
tamoxifen, clomiphene
hyperglycemia
tacrolimus, protease inhibitors, niacin MCTZ, coricosteroids
hypthyroidism
lithium, amiodarne, sulfonamides
acute cholestatic hepatitis jaundice
erythromycin
diarrhoea
metforim, erythromycin, colchicine, orlistate, acarbose
focal to massive hepatic necrosis
halothane, amanita phalloides, acetaminophen, calporic acid
hepatitis
rifampin, isoniazind, pyrazinamide, statins, fibrates
pancreatitis
alcohol, azathioprine, didanosine, corticosteroids, valproic acid, furosemide, HCTZ
agranulocytosis
ganciclovir, clozapine, colchicine, carbamazepine, methimazole, propylthiouracil
aplastic anaemia
benzene, NSAIDs, chloramphenicol, carbamazepine, methimazole, propylthiouracil
direct coombs positive anaemia
methyldopa, penicillin
gray baby syndrome
chloramphenicol
hemolysis in G6PD deficiency
isoniazid, sulfonamides, dapson, primaquine, aspirin, ibuprofen, bitrfurantoin