Repro - POTS

Question 1

epithelium of ectocervix and vagina?

Answer 1

non-keratinizing stratified squamous epithelium

Question 2

columnar cells function?

Answer 2

secretory

Question 3

where do you find pseudostratified ciliated columnar cells?

Answer 3

epididymis

vas deferens

Question 4

endocervix secretes?

Answer 4

mucus from glands, also columnar

Question 5

in reproductive years what happens to cervix?

Answer 5

expansion of cervical stroma from increased estrogen, exposed to hostile vagina = metaplasia

Question 6

why stratified squamous cells clear on H&E?

Answer 6

glycogen doesn’t stain

Question 7

cervix for protection?

Answer 7

lymphoid tissue and antigen presenting cells abundant

Question 8

HPV preferentially acts on what cells?

Answer 8

metaplastic squamous epithelium

Question 9

HPV infection characterised by presence of?

Answer 9

koilocytes, clear cytoplasm around irrefular nuclei in upper epithelium

Question 10

CIN1 has nuclear atypia where?

Answer 10

lower third of stratified squamous epithelium + koilocytes in upper epithelium

Question 11

CIN2 cells look like?

Answer 11

dysplasia, hyperchromia, nuclear atypia in lower 2/3rds

Question 12

CIN3 involvement?

Answer 12

full thickness dysplasia, pleomorphic

Question 13

cervical cancer spreads where?

Answer 13

uterus
vagina
bladder
rectum

Question 14

pap smear examines which zone?

Answer 14

transformation zone

squamous and columnar

Question 15

pap smear diagnostic or screening?

Answer 15

screening

Question 16

PAP smear reported in which manner?

Answer 16

1. Low grade squamous intraepithelila lesion (LSIL or CIN1)

2. High grade squamous intraepithelila lesion (HSIL or CIN2,3)

Question 17

how can you tell if endometrium is in secretory phase?

Answer 17

‘saw tooth’, coiled glands, no mitotic activity

Question 18

3 main types of ovarian cancers:

Answer 18

1. germ cell
2. stromal cell
3. epithelial (most common)