Cervical HPV Dysplasia Carcinoma

Question 1

HPV is attributed to how much % of Cervical, Anal, Penis and Vaginal cancers?

Answer 1

Cervical: 100%
Anal: 90%
vaginal, Penile: 40%

Question 2

two most prevalent strains of HPV?

Answer 2

HPV -16

HPV-18

Question 3

highes risk of HPV age?

Answer 3

20-24

14-19

Question 4

in order to infect: HPV must be where?

Answer 4

contact basement membrane

Question 5

What are the HPV early genes?

Answer 5

E1-7

Replication and nucleic acids

Question 6

what are HPV late genes?

Answer 6

L1-major capsids

L2 - minor capsids

Question 7

HPV replicated where in cell? as what form?

Answer 7

nucleus as circular episomes

Question 8

where is HPV amplified once infected?

Answer 8

amplified in basal keratinocytes

Question 9

HPV E6 does what?

Answer 9

deactivated p53 - cell won’t apoptose from infection

Question 10

HPV E7 does what?

Answer 10

blocks RB genes and allow dysplasia and metaplasia

Question 11

Prolonged HPV does what to host genome?

Answer 11

integrates itself = high grade and invasive carcinoma

Question 12

what is a cervical condyloma?

Answer 12

cervix becomes thicken papillomatous

Question 13

what is a flat cervical condyloma?

Answer 13

keratinocytes are enlarges, darker abnormal appearance, haphazard arrangement
appearance of koilocytes

Question 14

CIN 1?

Answer 14

basal 1/3 cell disorder

Question 15

CIN 2?

Answer 15

basasl 2/3 cell disorder

Question 16

CIN 3?

Answer 16

full thickness of epithelium affected

Question 17

what do you see in cervical squamous cell carcinoma

Answer 17

irregular and infiltrative ‘nests’

Question 18

cervical adenocarcinoma in situ apperance?

Answer 18

large atypical nuclei, glandular appearance, polymorphic, no polarity

Question 19

What is low grade squamous intraepithelial lesion? (LSIL)

Answer 19

CIN1
binucleation
koilocytes

Question 20

What is high grade squamous intraepithelial lesion? (HSIL)

Answer 20

CIN2,3

large nuclei, hyperchromatic

Question 21

HPV vaccine design against what in the virus?

Answer 21

late phase proteins L1,2

Question 22

if abnormal smear, then what?

Answer 22

colposcopic assessment