Repro Drugs Flashcards
GnRH analogue side effects
Time scale for use
Vasomotor symptoms eg. Hot flushes
Osteoporosis
-min 3 months and max 6 months
What must Danazol be used alongside with
Contraception
danazol is an androgen similar to testosterone used to treat endometriosis etc
when can progesterone only pill (POP) be given postpartum
anytime
when can the COCP be givenpost partum
> 21 days post partum no matter what (as <21 days inc risk of thrombembolic event)
if breast feeding then has to be >6 to 6months
when can the IUD/ IUS be inserted postpartum
either within 48 hours after childbirth or after four weeks
when is IUD contraindicated
pelvic infection, distorted uterus, hx of frwuent STIs, unexplained bleeding, abnormal cervix
what does co-amoxiclav cover and what is a concern when using this regarding pregnancy
wide cover but does not cover MRSA or psuedomonas
Concern about an increase in the risk of necrotising
enterocolitis in neonates exposed to co-amoxiclav in utero
metronidazole cover
anaerobes only
clindamycin cover
streptococci and staphylococci including MRSA
tazocin and carbopenems cover
Covers all except MRSA and are renal sparing (in contrast to aminoglycosides).
what are the rules for missing a progesterone only pill
<3 hours no action needed
>3 hours- take as soon as possble and condoms/no sex for 48 hours
(unless desogestrel in which same applies but has a 12 hour window instead)
how long does the contraceptive injection last
12 weeks
how long does the subdermal implant last (eg. nexplanon)
3 years
how does nexplanon work
progesterone only contraceptive, inhibits ovulation.
(implant)
(implant is the most effective contraception)
what is the period of greatest teratogenic risk
wks 4-11 (1st trimester basically)
drugs to avoid in pregnancy and why:
androgens: virillisation of female foetus
anti-epileptics- cardiac, neuraltube etc defects- 2nd/3rd tri
cancer tx- defects/abortion
lithium- CVS defects
warfarin- limb and facial defects
aspirin- reyes syndrome (swelling of liver/brain)
drugs to avoid during breast feeding and why
phenobarbitane- suckling difficulties
amiodarone- neonatal hypothyroidism
benzos- drowsiness
bromocriptine- dec lactation
cytotoxics- bone marrow supression
tetracycline and doxy- causes teeth discolouration
why does false labour occur/braxton hicks
near the time of due date prgesterone drops whilst oestrogen increases. as progesterone drops and progesterone reduces uterine contractility- the drop of this allos for small uterine contractions.
