Repro Drugs Flashcards

1
Q

GnRH analogue side effects
Time scale for use

A

Vasomotor symptoms eg. Hot flushes
Osteoporosis

-min 3 months and max 6 months

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2
Q

What must Danazol be used alongside with

A

Contraception
danazol is an androgen similar to testosterone used to treat endometriosis etc

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3
Q

when can progesterone only pill (POP) be given postpartum

A

anytime

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4
Q

when can the COCP be givenpost partum

A

> 21 days post partum no matter what (as <21 days inc risk of thrombembolic event)

if breast feeding then has to be >6 to 6months

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5
Q

when can the IUD/ IUS be inserted postpartum

A

either within 48 hours after childbirth or after four weeks

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6
Q

when is IUD contraindicated

A

pelvic infection, distorted uterus, hx of frwuent STIs, unexplained bleeding, abnormal cervix

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7
Q

what does co-amoxiclav cover and what is a concern when using this regarding pregnancy

A

wide cover but does not cover MRSA or psuedomonas

Concern about an increase in the risk of necrotising
enterocolitis in neonates exposed to co-amoxiclav in utero

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8
Q

metronidazole cover

A

anaerobes only

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9
Q

clindamycin cover

A

streptococci and staphylococci including MRSA

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10
Q

tazocin and carbopenems cover

A

Covers all except MRSA and are renal sparing (in contrast to aminoglycosides).

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11
Q

what are the rules for missing a progesterone only pill

A

<3 hours no action needed
>3 hours- take as soon as possble and condoms/no sex for 48 hours

(unless desogestrel in which same applies but has a 12 hour window instead)

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12
Q

how long does the contraceptive injection last

A

12 weeks

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12
Q

how long does the subdermal implant last (eg. nexplanon)

A

3 years

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13
Q

how does nexplanon work

A

progesterone only contraceptive, inhibits ovulation.

(implant)
(implant is the most effective contraception)

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14
Q

what is the period of greatest teratogenic risk

A

wks 4-11 (1st trimester basically)

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15
Q

drugs to avoid in pregnancy and why:

A

androgens: virillisation of female foetus

anti-epileptics- cardiac, neuraltube etc defects- 2nd/3rd tri

cancer tx- defects/abortion

lithium- CVS defects

warfarin- limb and facial defects

aspirin- reyes syndrome (swelling of liver/brain)

16
Q

drugs to avoid during breast feeding and why

A

phenobarbitane- suckling difficulties

amiodarone- neonatal hypothyroidism

benzos- drowsiness

bromocriptine- dec lactation

cytotoxics- bone marrow supression

tetracycline and doxy- causes teeth discolouration

17
Q

why does false labour occur/braxton hicks

A

near the time of due date prgesterone drops whilst oestrogen increases. as progesterone drops and progesterone reduces uterine contractility- the drop of this allos for small uterine contractions.