renal path Flashcards

1
Q

RBC casts in urine can be

A

glomerulonephritis, ischemia or malignant hypertension

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2
Q

WBC casts in urine can be

A

tubuloinstistial imflammation, acutepyleonephritis, transplant rejection

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3
Q

fatty casts in urine can me

A

nephrotic syndrome

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4
Q

muddy brown casts in urine

A

acute tubulat necrosis

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5
Q

waxy casts in urine

A

advanced renall disease/chronic renal failure

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6
Q

hematuria w/o casts

A

bladder cancer or kidney stones

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7
Q

pyuria w/o casts

A

acute cystitis

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8
Q

conditions causing nephritc syndrome

A

actute poststrep glomurulonehritis
rapidly progressive nephritis
berger’ IgA glomulonephropathy
alport syndrome

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9
Q

conditions causing nephrotic syndrome

A
focal segmental glomurosclerosis
membranous nepphropathy
minimal change disease
amyloidosis
diabetic glomueronephropathy
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10
Q

nephrotic syndrome in general

A

massive proteinuria, hyperlipdemia, fatty casts, edema

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11
Q

most common cause of nephrotic syndrome in adults

A

focal segmental glomerulosclerosis

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12
Q

can bring on focal segmental glomerulosclerosis

A

HIV, heroin, massive obesity, interferon tx, chronic kidney dx due to congenital absence or surgical removal

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13
Q

focal segmental glomerulosclerosis on LM

A

segmental sclerosis and hyalinosis

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14
Q

focal segmental glomerulosclerosis on EM

A

effacement of foot process

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15
Q

granular on IF nephrotic syndrome

A

membranous neprhopathy

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16
Q

SLE’s nephrotic manifestation

A

membranous neprhopathy

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17
Q

“spike and dome” on EM

A

membranous neprhopathy

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18
Q

diffuse capillary and GBM thickening on LM

A

membranous neprhopathy

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19
Q

normal on LM and foot processes effacement on EM

A

minimal change dx

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20
Q

tx for minimal change dx

A

steroids

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21
Q

LM shows apple-green bifringence under polorized light when stained with congo red

A

amyloidosis

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22
Q

can cause kidney chronic conditions

A

Myeloma, TB, RA

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23
Q

train track apprarence in EM

A

membranoproliferative gomerulonephritis type I

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24
Q

nephrotic subendothelial IC deposits with granular IF

A

membranoproliferative gomerulonephritis type I

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25
nephrotic intramembranous IC deposits
membranoproliferative gomerulonephritis type II
26
nephrotic syndrome associated with HBV,HCV
membranoproliferative gomerulonephritis type II
27
associated with C3 nephritic factor
membranoproliferative gomerulonephritis type II
28
nephrotic with mesangial expansion, GBM thickening, eosiinophilic nodular glomerulosclerosis
diabetic glomeronephropathy
29
hemturia, RBC casts in urine, azotemia, oliguria, hypertension
nephritic syndrome
30
nephritis with LM shows glomeruli that are enlarged and hypercellular with "lumpy bumpy" apperance
acute post-strep glomerulonepthritis
31
nephritis with IF showing granular appearence
acute post-strep glomerulonepthritis
32
deposits in acute post-strep glomerulonepthritis
IgG, IgM and C3
33
kids with peripheral and periprbital edema, dark urine and hypertension
acute post-strep glomerulonepthritis
34
nephritic syndome with LM and IF cresent moon shapes
rapidly progressive glomerulonephritis
35
kidney manifestation of Goodpasture's
rapidly progressive glomerulonephritis
36
kidney manifestion of granulomatosis with polyangiitis
rapidly progressive glomerulonephritis
37
C-ANCA/P-ANCA
rapidly progressive glomerulonephritis asociated with polyangitiis
38
prognosis of rapidly progressive glomerulonephritis
poor - days to weeks until loss of renal function
39
nephritic manifestation of SLE
diffuse proliferative glomerulonephritis
40
nephritic syndrome with wire looping of capillaries in LM and granular IF
diffuse proliferative glomerulonephritis
41
most common cause of death in SLE
diffuse proliferative glomerulonephritis
42
nephritic syndrome flaring with URTI or acute GI-itis
IgA nephropathy
43
glomularnonephritis, deafness and sometimes eye issues
alport's syndrome (mutation in IV collegen, X linked)
44
most common kidney stone
calcium
45
tx for calcium stones
thiazides, citrate,
46
conditions that can cause calcium stones
cancer, high PTH, ethylene glycol ingestion, vitamin C abuse
47
causes struvite stones
ammonium Mg phosphate
48
etioligy of struvite stones
urease + bacteria (proteus, staph, klebsiealla)
49
radiolucent stones
uric acid stones
50
uric acid stones can be a sign of
leukemia
51
high urine pH stones
calcium phosphate, amonnium Mg phosphate
52
gene defect in renal cell carcinoma
gene deletion on chromosome 3 (may be vHL)
53
systemic effect of renal cell carcinoma
paraneoplastic syndromes (ectopic EPO, ACTH or PTHrP)
54
tx for renal cell carcinoma
surgery if local (resistant to chemo and rads)
55
risks for transitional cell carcinoma
phenacetin, smokingm analine dyes, cyclophosphomide
56
drugs that can cuase intersistial nephritis
diuretics, penicillins, sulfanamides, rifampin NSAIDS after long-term use
57
most common cause of intrinsic renal failure
acute tubular necrosis
58
can cause acute tubular necrosis
renal ischemia, rhabdo, drugs, toxins
59
key finding in acute tubular necrosis
muddy brown casts
60
gross hematuria and proteinuria with recent infectiion or immune stimulus
renal papillary necrosis
61
can cause renal papillary necrosis
DM acute kidney infection tylenol use sickle cell
62
sign of acute kidney failure
abrupt decline in renal function with increased creatine and BUN
63
knock on effects of kidney failure
salt/water retention hyperkalemia matabolic acidosis uremia (N/v, pericarditis, encephalopatjy, platelet dysfcuntion) anemia due tolow EPO low vit D growth retardation and developmental delay in kids
64
ADPKD extra kidney manifestations
berry anyrsusms, MVP, benign hepatic cysts
65
inherited dx with tubilointersistial fibrosis and pregrossive renal insiffiency qith inability to concentrate urine
medullary cystic dx (poor prognosis)