MSK path

Question 1

overactivation of what causes achrondroplasia

Answer 1

FGFR3 (inhibits chondrocyte proliferation)

Question 2

genetics of achondroplasis

Answer 2

usuelly sporadic mutation (linked with father’s old age), AD mendalian inheritance

Question 3

tx of osteopetrosis

Answer 3

bone marrow transplant

Question 4

thick bones prone to fracture in kids

Answer 4

osteopetrosis

Question 5

thick bones prone to fracture in adults

Answer 5

paget’s dx of bone

Question 6

old guy with increasing hat size and hearing loss

Answer 6

paget’s dx

Question 7

normal labs and low bone mass

Answer 7

osteoporosis

Question 8

low Ca/High ALP with thickened dense bones

Answer 8

osteopetrosis

Question 9

high ALP with abnormal bone

Answer 9

paget’s

Question 10

soap bubble tumor of end of long bones age 20-40

Answer 10

osteoclastoma

Question 11

most common benign bone tumor

Answer 11

osteochondroma

Question 12

mature bone with cartiliage cap from long metaphysis

Answer 12

osteochondroma

Question 13

codman’s triangle or sunburst pattern on x-ray

Answer 13

osetosarcoma

Question 14

most common long bone tumor

Answer 14

osteosarcoma

Question 15

male teenage aggressive malagnant tumor of distal femur

Answer 15

osteosarcoma

Question 16

young boy tumor in diaphys of long bones, pelvis, scapula, and ribs

Answer 16

Ewing’s

Question 17

blue cell tumor with onion skin appearance

Answer 17

Ewing’s

Question 18

translocation of Ewing’s

Answer 18

11;22

Question 19

men 30-60 glistening mass within medullary cavity

Answer 19

chondrosarcoma

Question 20

arthritis in distal joints

Answer 20

OA

Question 21

serum marker in RA

Answer 21

RA factor, HLA-DR4

Question 22

dry eyes, dry mouth, arthritis

Answer 22

sjogren’s

Question 23

causes sjogren’s

Answer 23

lymphatic infiltration of exocrine glands

Question 24

sjogren’s found with

Answer 24

RA

Question 25

needle shaped yellow crystals in joints

Answer 25

gout

Question 26

neddle shaped blue crystals in joints

Answer 26

pseudogout

Question 27

bugs causing infectious arthrists

Answer 27

S aureus, Streptococccus, N gonorrhoae

Question 28

can’t see, can’t pee, can’t climb a tree

Answer 28

reactive arthritis

Question 29

lab test showing poor prognosis in SLE

Answer 29

anti-dsDNA

Question 30

CREST syndrome

Answer 30

calcinosis, raynaud’s, esophageal dymotality, Schleordactyly, and telangiasia

Question 31

antibody in CREST

Answer 31

antiCentromere

Question 32

small, flat lesion

Answer 32

macule (freckle)

Question 33

large flat lesion

Answer 33

patch (large birthmark)

Question 34

elevated small lesion

Answer 34

papule (mole, acne)

Question 35

large elevated lesion

Answer 35

plaque (psoriasis)

Question 36

small blister

Answer 36

vesicle (chickenpox/shingles/herpes)

Question 37

large blister

Answer 37

bulla (bullous pemphigoid)

Question 38

stuck on lesions

Answer 38

sebhooric keratosis

Question 39

puritic papules, and blisters associated with celiac

Answer 39

dermatitis herpetiformis (IgA attops of dermal papillie)

Question 40

severe autoimmune blistering disease (breaking blisters)

Answer 40

pemphigus vulgaris - net like immunoflourescence

Question 41

milder autoimmune blistering disease with tense bluisters

Answer 41

bullous pemphgoid - linear immunoflourecense

Question 42

actinic keratosis can move to

Answer 42

SCC

Question 43

can cause acanthosis nigrins

Answer 43

hyperglycemia, and visceral malignancy

Question 44

inflammatory lesions of SubQ fat, usually on shins

Answer 44

erythema nodusum

Question 45

can cause erytheme nodusum

Answer 45

sarcoidosis, coccidiomycosis, leprosy, Crohn’s

Question 46

causes necrotizing fasctitiis

Answer 46

s pyigenes

Question 47

pearly pink nodules with blood vessels

Answer 47

Basal cell

Question 48

keratin pearls

Answer 48

SCC

Question 49

mutation in melanoma

Answer 49

BRAF Kinase