Neuro-path

Question 1

genes in early onset alzheimer’s

Answer 1

APP (21), pesenilin-1 (14), presinilin-2 (1)

Question 2

genes in late onset alzeimer’s

Answer 2

ApoE4

Question 3

protective gene against alzeimer’s

Answer 3

ApoE2 (19)

Question 4

protein in alzheimer’s plaques

Answer 4

Amyloid AB

Question 5

protein in alzheimer’s tangles

Answer 5

tau protein

Question 6

parkinson’s with hallucinations/dementia

Answer 6

lewy-body dementia

Question 7

defect protein in lewy body dementia

Answer 7

a-synuclien

Question 8

bad prion form in CJD

Answer 8

PrP(sc)

Question 9

vitamin deficiencies that can cause dementia

Answer 9

B1/B2/B12

Question 10

triad sx of MS

Answer 10

scanning speech, intention tremor/incontinince, nystgamus

Question 11

common demographics for MS

Answer 11

white women in 20-30s

Question 12

CSF findings in MS

Answer 12

IgG, oglioclonal bands

Question 13

sx of MS

Answer 13

B-interferon, immunosuppression, natalizumab,

Question 14

drug for MS spasticity

Answer 14

baclofen

Question 15

infections that can precipitate GB

Answer 15

camplyobacter, CMV

Question 16

tx for GB

Answer 16

supportive, plasmapheresis, IV immune globlulins

Question 17

GB findings

Answer 17

CSF protein with normal cell count, papilledema

Question 18

dx due to deficincu of galacrocebrosidase

Answer 18

krabbe’s sx

Question 19

causes progressive leukoencephalopathy

Answer 19

AIDS or JC virus

Question 20

focal point of most seizures

Answer 20

temporal lobe

Question 21

abortive tx for migraines

Answer 21

triptans

Question 22

prophylaxic for migranes

Answer 22

B blockers, topirmate

Question 23

port wine stains in V1 distibution, ipsilateral leptomeningeal angiomas, pheos

Answer 23

sturge-Weber

Question 24

hamatroms, ash leaf spots, MR, seizure, mitral regurg, cardiac rhabdo

Answer 24

tuberous sclerosis

Question 25

cafe-au lait spots, lisch nodules, NFs in skin, optic gliomas, pheos

Answer 25

neurofibromatosis 1 (NF1 AD)

Question 26

cavernous hemangiomas in skin, bilateral renal cell carcinomas, hemangioblastomas in retina, brain stem, cerebellum, pheos

Answer 26

Von Hippel lindau (VHL AD)

Question 27

most common adult primary tumor

Answer 27

glioblastoma

Question 28

most aggressive adult brain tumor

Answer 28

glioblastoma

Question 29

glioblastomas stain for

Answer 29

GFAP

Question 30

common benign adult brain tumor

Answer 30

meningioma

Question 31

histology of meningioma

Answer 31

spindle cells in whorled pattern, psomoma bodies

Question 32

schwannomas localize to

Answer 32

CNVIII (commonly at cerebropontine angle)

Question 33

"fried egg" looking brain tumors

Answer 33

oligodendroma

Question 34

childhood brain tumors that can cause hydrocephalus

Answer 34

ependyoma

Question 35

most malignant childhood tumor

Answer 35

medulloblastoma

Question 36

benign posterior fossa childhood brain tumor

Answer 36

pilocytic astrocytoma

Question 37

perivascular pseudorosettes

Answer 37

epedyoma

Question 38

nearly instantly fatal herniation

Answer 38

tonsillar herniation