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path-cancer facts Flashcards

1
Q

neoplastic progression

A

hyperplasia –> dyplasia–> carcinoma in situ –> invasive carcinoma –> mets

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2
Q

last reversable step toward cancer

A

dysplasia

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3
Q

more prognostic value - stage or grade

A

stage

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4
Q

cancer associated with down syndrome

A

ALL

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5
Q

cancer associated with xeroderma pigmentosum

A

skin cancers, esp SCC

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6
Q

cancer associated with chronic gastritis

A

gastric adenocarcinoma

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7
Q

cancer associated with tuberous scleroisis

A

giant cell astrocytoma, angiomyolipoma, cardiac rhabdomyoma

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8
Q

cancer associated with actinic keratosis

A

SCC

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9
Q

plummer vinson

A

SCC of esophagus

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10
Q

barrett’s

A

adenocarcinoma of esophagus

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11
Q

cirrhosis

A

hepatocellular carcinoma

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12
Q

ulcertice colitis

A

colonic adenocarcinoma

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13
Q

paget’s dx of bone

A

osteocarcinoma, fibrosarcoma

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14
Q

immunodeficncy

A

maligant lymphoma

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15
Q

AIDS

A

aggressive malignant lymphoma and Kaposi’s

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16
Q

autoimmune dx

A

lymphoma

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17
Q

aconthrosis nigricans

A

visceral malignancy

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18
Q

dysplastic nevus

A

melanoma

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19
Q

radiation exposure

A

leukemia, sarcoma, papillary thyroid cancer

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20
Q

abl oncogene associated with

A

CML

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21
Q

c-myc oncogene associated with

A

burkitt’s lymphoma

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22
Q

bcl-2 oncogene associated with

A

follicular and undifferentiated lymphomas

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23
Q

HER2/neu oncogene associated with

A

breast, ovarian and gastric

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24
Q

ras oncogene associated with

A

colon carcinoma

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25
L-myc oncogene associated with
lung tumor
26
N-myc oncogene associated with
neuroblastoma
27
ret oncogene associated with
MEN 2A/B
28
c-kit oncogene associated with
GI stromal tumor
29
Rb Tumor suppressor gene associated with
retinoblastoma, osteosarcoma
30
p53 suppressor gene associated with
most human cancers, li-fraumeni syndrome
31
BRCA1/2 suppressor gene associated with
breast.ovarian cancer
32
p16 suppressor gene associated with
melanoma
33
BRAF suppressor gene associated with
melanoma
34
APC suppressor gene associated with
colorectal cancer
35
DPC4 suppressor gene associated with
pancreatic cancer
36
DCC suppressor gene associated with
colon cancer
37
CEA a tumor marker for
(very nonspecific) colorectal and pancreatic cancer
38
alpha-fetoprotein a tumor marker for
hepatocellular carcinomas, nonseminomatus germ cell tumors
39
beta-hCG a tumor marker for
hydatiaform moles and choriocarcinomas
40
CA-125 a tumor marker for
ovarian cancer
41
S-100 a tumor marker for
melamoma, neural tumors, schwannomas
42
alkaline phosphatase a tumor marker for
mets to bone, liver and paget's dx of bone
43
bombesin a tumor marker for
neuroblastoma, lung and gastric cancer
44
Ca-19- a tumor marker for
pancreatic carcinoma
45
calcitonin a tumor marker for
medullary thyroid cancer
46
HTLV-1 can cause
adult T cell leukemia/lymphoma
47
HBV, HCV can cause
hepatocellular carcinoa
48
HPV can cause
penile/anal/cervical cancer, upper resp SCC
49
EBV can cause
burkitt's lymphoma, hodgkin's, nasopharyngeal cancer
50
liver fluke can cause
cholangiosarcoma
51
aflatoxins can cause
hepatocellular carcinoma
52
vinyl chloride can cause
angiosarcoma
53
CCl4 can cause
liver necrosis
54
smoked foods can cause
gastric cancer
55
smoking can cause
``` SCC of larynx and lung small cell cancer of lung renal cell carcinoma transitional cell carcinoma pancreatic carcinoma ```
56
arsenic can cause
SCC of skin | angiosarcoma
57
ACTH released by
small cell lung carcinoma
58
ADH released by
small cell carcinoma and intracranial neoplasms
59
PTHrP released by
SCC of lung, renal cell carcinoma, breast cancer
60
actiive vit D high in
hodgkin's lymphoma
61
Epo found in
renal cell carcinoma, hemangioblastoma, hepatocellular carcinoma, pheo
62
antibodies against presynaptic ca channels at NMJ - (lambert -eaton (muscle weakness))
small cell carcinoma
63
psommoma bodies found in
papillary, serous ovary, meningioma, mesothelioma

Step 1 - Path (12 decks)

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