path-cancer facts Flashcards

1
Q

neoplastic progression

A

hyperplasia –> dyplasia–> carcinoma in situ –> invasive carcinoma –> mets

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2
Q

last reversable step toward cancer

A

dysplasia

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3
Q

more prognostic value - stage or grade

A

stage

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4
Q

cancer associated with down syndrome

A

ALL

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5
Q

cancer associated with xeroderma pigmentosum

A

skin cancers, esp SCC

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6
Q

cancer associated with chronic gastritis

A

gastric adenocarcinoma

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7
Q

cancer associated with tuberous scleroisis

A

giant cell astrocytoma, angiomyolipoma, cardiac rhabdomyoma

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8
Q

cancer associated with actinic keratosis

A

SCC

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9
Q

plummer vinson

A

SCC of esophagus

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10
Q

barrett’s

A

adenocarcinoma of esophagus

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11
Q

cirrhosis

A

hepatocellular carcinoma

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12
Q

ulcertice colitis

A

colonic adenocarcinoma

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13
Q

paget’s dx of bone

A

osteocarcinoma, fibrosarcoma

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14
Q

immunodeficncy

A

maligant lymphoma

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15
Q

AIDS

A

aggressive malignant lymphoma and Kaposi’s

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16
Q

autoimmune dx

A

lymphoma

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17
Q

aconthrosis nigricans

A

visceral malignancy

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18
Q

dysplastic nevus

A

melanoma

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19
Q

radiation exposure

A

leukemia, sarcoma, papillary thyroid cancer

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20
Q

abl oncogene associated with

A

CML

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21
Q

c-myc oncogene associated with

A

burkitt’s lymphoma

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22
Q

bcl-2 oncogene associated with

A

follicular and undifferentiated lymphomas

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23
Q

HER2/neu oncogene associated with

A

breast, ovarian and gastric

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24
Q

ras oncogene associated with

A

colon carcinoma

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25
Q

L-myc oncogene associated with

A

lung tumor

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26
Q

N-myc oncogene associated with

A

neuroblastoma

27
Q

ret oncogene associated with

A

MEN 2A/B

28
Q

c-kit oncogene associated with

A

GI stromal tumor

29
Q

Rb Tumor suppressor gene associated with

A

retinoblastoma, osteosarcoma

30
Q

p53 suppressor gene associated with

A

most human cancers, li-fraumeni syndrome

31
Q

BRCA1/2 suppressor gene associated with

A

breast.ovarian cancer

32
Q

p16 suppressor gene associated with

A

melanoma

33
Q

BRAF suppressor gene associated with

A

melanoma

34
Q

APC suppressor gene associated with

A

colorectal cancer

35
Q

DPC4 suppressor gene associated with

A

pancreatic cancer

36
Q

DCC suppressor gene associated with

A

colon cancer

37
Q

CEA a tumor marker for

A

(very nonspecific) colorectal and pancreatic cancer

38
Q

alpha-fetoprotein a tumor marker for

A

hepatocellular carcinomas, nonseminomatus germ cell tumors

39
Q

beta-hCG a tumor marker for

A

hydatiaform moles and choriocarcinomas

40
Q

CA-125 a tumor marker for

A

ovarian cancer

41
Q

S-100 a tumor marker for

A

melamoma, neural tumors, schwannomas

42
Q

alkaline phosphatase a tumor marker for

A

mets to bone, liver and paget’s dx of bone

43
Q

bombesin a tumor marker for

A

neuroblastoma, lung and gastric cancer

44
Q

Ca-19- a tumor marker for

A

pancreatic carcinoma

45
Q

calcitonin a tumor marker for

A

medullary thyroid cancer

46
Q

HTLV-1 can cause

A

adult T cell leukemia/lymphoma

47
Q

HBV, HCV can cause

A

hepatocellular carcinoa

48
Q

HPV can cause

A

penile/anal/cervical cancer, upper resp SCC

49
Q

EBV can cause

A

burkitt’s lymphoma, hodgkin’s, nasopharyngeal cancer

50
Q

liver fluke can cause

A

cholangiosarcoma

51
Q

aflatoxins can cause

A

hepatocellular carcinoma

52
Q

vinyl chloride can cause

A

angiosarcoma

53
Q

CCl4 can cause

A

liver necrosis

54
Q

smoked foods can cause

A

gastric cancer

55
Q

smoking can cause

A
SCC of larynx and lung
small cell cancer of lung
renal cell carcinoma
transitional cell carcinoma
pancreatic carcinoma
56
Q

arsenic can cause

A

SCC of skin

angiosarcoma

57
Q

ACTH released by

A

small cell lung carcinoma

58
Q

ADH released by

A

small cell carcinoma and intracranial neoplasms

59
Q

PTHrP released by

A

SCC of lung, renal cell carcinoma, breast cancer

60
Q

actiive vit D high in

A

hodgkin’s lymphoma

61
Q

Epo found in

A

renal cell carcinoma, hemangioblastoma, hepatocellular carcinoma, pheo

62
Q

antibodies against presynaptic ca channels at NMJ - (lambert -eaton (muscle weakness))

A

small cell carcinoma

63
Q

psommoma bodies found in

A

papillary, serous ovary, meningioma, mesothelioma