πŸ‘©πŸΎβ€πŸŽ“- Renal & Crisis Test Flashcards

0
Q

Two functions of the kidney

A

Regulatory- controls fluid/electrolyte & acid/base balance

Hormonal- RBC formation, BP regulation, vitamin D activation

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1
Q

What is the functional unit of the kidney

A

Nephrons

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2
Q

Normal renal function values

BUN, creatinine, Uric acid, GFR, urine output

A

BUN- 8 to 25 mg/dL

Creatinine- 0.6 to 1.3 mg/dL

Uric Acid- 2.5 to 8.0 mg/dL

GFR- 125 ml/min

Urine output- 1 to 3 L/day

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3
Q

Hormones in kidney function

A

ADH- antidiuretic hormone regulates osmolarity

RAAS- renin angiotensin aldosterone System regulates BP and volume

ANF- atrial natriuretic factor regulates BP and volume

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4
Q

Decreased GFR will cause which hormone to be secreted

A

Renin

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5
Q

3 most common causes of kidney disease

A

Diabetes
Hypertension
Glomerulonephritis

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6
Q

Types of drugs that are nephrotoxic

Example of each

A

NSAIDS - ibuprofen, naproxen, ketorolac

Chemo- cisplatin, methotrexate, cyclophosphamide

Antibiotics- vancomycin, gentamicin, amphotericin B, methicillin

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7
Q

Acute kidney injury vs chronic kidney disease

A

AKI- sudden onset, about 50% kidney function, usually last a few weeks but no more than 3 months, with treatment function resolved to original state

CKD- gradual onset, permanent, less than 10% function is present, fatal with renal replacement therapy

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8
Q

Three causes/subcategories of AKI

A

Prerenal- outside the kidney, caused by decreased intravascular volume, sepsis, dehydration and obstruction

Intrarenal- actual damage to renal parenchyma, causes by tubular necrosis, prolonged prerenal ischemia, infection and nephrotoxicity

Postrenal- obstruction of urinary outflow from the collecting ducts in the kidney to the external urethral orifice, causes renal stones, bladder tumors, prostate cancer, blood clots

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9
Q

4 phases of acute kidney injury

A

Onset phase- begins with precipitating event

Oliguric phase- urine output below 400mL/day. HIGH electrolyte levels. Requires supportive measures (no nephrotoxic drugs, decrease BP and possible dialysis). ⬇️ gfr, hyperkalemia, hypocalcemia

Diuretic phase- occurs when cause of AKI has been corrected. Urine output from 3-5L/day. LOW electrolyte levels.

Recovery phase- NORMAL electrolyte levels. ⬆️ gfr, complete recovery may take 1-2yrs. Memory improves

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10
Q

How is AKI diagnosed

A

X-ray (kub)

Renal ultrasound

Serum labs (CBC, bun/creatinine, electrolytes)

Urine labs (24hr collection, u/a, specific gravity)

CT scans/MRI

Nuclear imaging

Cystoscopy

Renal biopsy

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11
Q

Clinical manifestations of hypovolemia or reduced CO

Prerenal azotemia

A

Hypotension

Tachycardia

Decreased Central Venous Pressure

Decreased urine output

Weakness/fatigue

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12
Q

S&S of volume overload

Intrarenal or postrenal azotemia

A

Hypertension

Tachycardia

Increased central venous pressure

Increased jugular vein distention

SOB, crackles, pulmonary edema

Weight gain/ edema

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13
Q

Azotemia

S&S

A

Inability to secrete waste, elevated BUN

S&S- n/v, anorexia, headache, confusion, weakness/fatigue

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14
Q

Lab changes during an AKI

A

⬆️ BUN

⬆️ creatinine

⬆️ K, Ph, Mg, PaCO2

⬇️ Ca, HCO3

↕️ Na is variable

↕️ H&H are usually stable unless patient is hemorrhaging

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15
Q

Normal lab values

Bun, creatinine, k, ph, Mg, Ca, Na, hemoglobin, hematocrit, HCO3, PaCO2

A

Bun: 10-20 mg/dL

Creatinine: 0.5-1.1 mg/dL

K: 3.5-5 mEq/L

Phosphorus: 3-4.5 mg/dL

Mg: 1.3-2.1 mEq/L

Ca: 9-10.5 mg/dL

Na: 135-145 mEq/L

Hemoglobin: 12-17 mmol/L

Hematocrit: 38-50%

HCO3: 22-26 mEq/L

PaCO2: 35-45 mmHg

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16
Q

What is the most serious electrolyte disorder in kidney injury

A

Hyperkalemia

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17
Q

How is hyperkalemia treated

A

IV insulin

IV glucose (push k back in cell. Glucose to prevent hypoglycemia)

IV Ca gluconate (⬇️ threshold ❀️ arrhythmia)

Sodium polystyrene sulfonate (kayexelate)

Lasix, sodium bicarb, albuterol nebs

Emergent hemodialysis

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18
Q

Under what conditions should kayexelate NOT be given

A

Hypoactive bowels

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19
Q

Common causes of chronic kidney disease

A

Diabetes

Hypertension

Glomerulonephritis (lupus, wegeners, hiv, amyloidosis)

Interstitial nephritis (allergic or pvelo)

Microangiopathic vascular disease (scleroderma)

Cogenital

Genetic disease (pkd)

Neoplasm or tumor

Transplant rejection

Hepatorenal syndrome

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20
Q

Hepatorenal syndrome

A

Life-threatening medical condition that consists of rapid deterioration in kidney function in individuals with cirrhosis or liver failure

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21
Q

List the 5 phases of chronic kidney disease

A

Stage I- gfr > 90ml/min. (Screen)

Stage II- gfr 60-89ml/min (Reduce risk factors)

Stage III- gfr 30-59ml/min (Slow progression)

Stage IV- gfr 15-29ml/min (Manage/rrt)

Stage V- gfr < 15ml/min (Rrt/transplant)

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22
Q

Ca has an adverse relationship with which other electrolyte

A

⬇️ Ca = ⬆️ phosphate

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23
Q

Lab changes in CKD

A

Bun & creatinine gradual increase to very high levels

Na initial decrease, later maybe increased or β€œnormal”

K & Ph rise quickly

Ca decreased

Metabolic acidosis due hydrogen ions not being excreted and unable to bind to HCO3

⬇️ iron, folic acid. ⬆️ cholesterol

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24
People with CKD are more prone to which 3 conditions
Metabolic acidosis , ❀️ problems and bleeding
25
Cardiovascular changes in CKD At risk for ?
Hypertension Fluid overload Heart failure (results from htn, hypervolemia, anemia and ultimately causes LV enlargement) Risk for- CAD, pericarditis, pericardial effusion
26
Pulmonary changes in CKD
Dyspnea/tachypnea (watch for kussmauls) Crackles Pulmonary effusions Pulmonary edema Pneumonitis
27
Kussmauls breathing indicates what
Severe acidosis | Associated with CKD
28
Neurological changes in CKD Untreated?
Lethargy Decreased alertness/cloudy mentation Poor concentration Neuropathy If untreated can cause seizures, coma
29
Integument changes in CKD
Yellow or darkening of skin Pruritus Uremic frost (uremia seeping from pores)
30
Urinary changes in CKD
Initially May appear β€œnormal” Oliguric Anuric (may occur once crrt is initiated)
31
Psychosocial concerns in CKD
Anxiety Depression Fear of death Economic status changes Loss of independence Loss of control Role change at home and/or work
32
S&S of uremic syndrome
Anorexia, n/v Weakness, fatigue Itching Uremic frost Muscle cramps Hiccups Stomatitis Ulcers Bowel changes (diarrhea or constipation)
33
Prescribed diet for some in CKD would consist of
Moderate protein (to decrease the workload on the kidneys) High carb Low potassium , low phosphorus
34
Dietary changes for CKD Fluid, protein, k, na, ph
Fluid- restricted to 1-1.5 L/day Protein- restricted in early stages because it slows CKD K- restricted to 70 mEq/day Na- typical restriction is 2g/day Ph- restricted to 700 mg/day
35
Hemodialysis vs CRRT vs Peritoneal dialysis
Hemodialysis- fluid & waste removal with dialysate and ultrafiltration via machine, generally required 12 hours/week in divided treatments, may be used emergently CRRT- fluid & waste removal by hemofiltration (and sometimes dialysate) via machine, continuous treatment, typically reserved for icu Peritoneal dialysis- fluid & waste removal with dialysate and ultrafiltration in peritoneal cavity
36
List the 5 types of crrt
Continuous veno-venous hemofiltration CVVH: filter only, no dialysate Continuous veno-venous hemodiafiltration CVVHD: filter & dialysate Continuous arterio-venous hemofiltration CAVH: filter only, no dialysate Continuous arterio-venous hemodiafiltration CAVHD: filter & dialysate SCUF: slow continuous ultrafiltration
37
What 3 things must be prescribed by a doctor in hemodialysis treatment
Dialysate, Time (schedule) and ultrafiltration
38
How does dialysate function
Regulates blood acidity and electrolytes
39
Two primary types of hemodialysis access
Venous catheter (external access) Fistula or graft (internal access)
40
Venous catheters and hemodialysis access Vascath, permcath
Inserted in jugular, subclavian or femoral vein Vascath (non tunneled)- temporary Permcath (tunneled)- lasts longer than vascath, but not intended to be permanent
41
Internal access and hemodialysis access Fistula, graft
AV fistula- surgical anastomosis of vein and artery AV graft- surgical implantation of artificial graft to connect vein & artery (listen for bruit and thrill)
42
Hemodialysis access: risks Venous catheters vs internal access
Venous catheters- infection, embolism (air or thrombus), pneumothorax after insertion AV fistula or graft- infection, clotting, loss of blood flow secondary to hypotension, steal syndrome, aneurysm in access
43
Steal syndrome
Ischemia resulting from a vascular access device | Risk associated with fistula or graft hemodialysis access
44
Disequilibrium syndrome S&S, treatment
Occurrence of neurological s&s attributed to cerebral edema during or following shortly after hemodialysis S&S- vomiting, confusion, headache, twitching, seizures Treatment- slow or stop dialysis and give hypertonic saline and mannitol to pull off fluid from brain
45
List 4 things to report immediately associated with issues in a fistula or graft
Loss of thrill S&S of infection Bulging Pain
46
Hemodialysis: special considerations
- daily weights before and after treatment - know your patients dry weight - medication management around dialysis - protect and assess access continually - assesses the CKD patient appropriately (watch hemodynamics and monitor for complications)
47
Dietary considerations for the HD patient
Fluid restriction Less Na Less proteins 8-10 oz/daily Grains/cereal/bread 6-11 servings Milk, cheese, yogurt 1 oz/day (⬆️ phosphorus) Veggies & fruit 2-3 servings each (watch for K)
48
When was peritoneal dialysis and hemodialysis first performed
Peritoneal dialysis- 1923 Hemodialysis- 1937 at the university of Lund, Sweden
49
Continuous ambulatory peritoneal dialysis CAPD
Dialysate is constantly in peritoneal cavity 4-5 manual exchanges during day Low concentration dialysate swells over night
50
Continuous-cycle peritoneal dialysis (CCPD, cycler)
Dialysis dwells primarily overnight 4-5 machine/cycler exchanges overnight Low concentration dialysate dwells during day
51
What 3 things are prescribed by a doctor in peritoneal dialysis
Dialysate, dwell time and additives
52
List the 3 dialysate options Higher concentration ?
1. 5% glucose 2. 5% glucose 4. 25% glucose * higher concentration of glucose, removes more fluid & solutes*
53
What are the 3 steps to perform peritoneal dialysis treatment (exchange)
1. Fill peritoneum with 1-2 L dialysate (takes about 20 mins) 2. Dwell dialysate (3-5 hrs) 3. Drain effluent (takes about 20mins)
54
What’s in hemodialysis dialysate
``` Sodium Bicarbonate Acetate Chloride Calcium Potassium Magnesium (Treated) tap water ```
55
What’s in peritoneal dialysis dialysate
``` Glucose Lactate Sodium Potassium Chloride Calcium Magnesium Hydrochloric acid (prevents caramelization) ```
56
Complications of peritoneal dialysis
- peritonitis - leakage - bleeding Long term: hypertriglyceridemia, abdominal hernia or exacerbation of hemorrhoids and hiatal hernia
57
S&S of peritonitis | associated with complications of PD
Cloudy drainage Abdominal pain Rebound tenderness Hypotension
58
Peritoneal dialysis dietary restrictions
Protein requirements increase (protein is pulled across the peritoneal membrane Fruits and vegetables aren’t restricted b/c PD patients don’t have issues with K regulation No fluid or sodium restriction Restricted phosphorus and carbs
59
List the 3 types of crisis
-maturational crisis Predictable, transitional points Ex: getting married in a few weeks -situational crisis Unexpected, unpredictable, common Ex: going through a divorce -adventitious crisis Unexpected, unpredictable, uncommon Ex: big and devastating
60
Crisis vs disaster
Crisis- upset in a previously steady state = poor problem solving Disaster- overwhelming event that leads to temporary disruption of function
61
Mass casualty vs multi casualty
Mass casualty- 100 or more affected Multi casualty- 2 but less than 100
62
List the 8 types of disaster
``` Internal External Predictable Unpredictable Natural Frequent Rare Manmade ```
63
Acts of terrorism Examples
Violence against persons or property in violation of the crimson laws of the U.S Ex- assassinations, kidnapping, hijacking, bombings, imputed based attacks, chemical/biological/nuclear/radiological weapons
64
Phases of a disaster
Mitigation- lessen the impact of a disaster before it strikes Preparedness- activities undertaken to handle a disaster when it strikes Response- search and rescues, clearing debris and feeding and sheltering victims Recovery- getting a community back to its pre-disaster status
65
Classic 5 response phases
Heroic- need to help Honeymoon- survivors reminisce Disillusionment- delay in receiving help Reconstruction- sense of normalcy PTSD- 1 to 3 months later
66
Who declares a state of emergency
Governor has to declare a state of emergency
67
S&S of transplant rejection
``` Oliguria Edema Fever Increasing BP Weight gain Swelling or tenderness over transplant site ```
68
S&S of kidney trauma
``` Flank pain Renal colic Hematuria Flank mass/swelling Ecchymosis Abdominal wounds ```
69
Emergency severity index
Five level triage algorithm 1 (most urgent) to 5 (least urgent)
70
Parkland formula
Calculates fluid requirements for burn patients in a 24hr period 4ml/kg x %TBSA
71
Heat exhaustion vs heat stroke Symptoms, treatment
- Exhaustion symptoms: faint or dizzy, excessive sweating, cool, pale, clammy skin, n/v, rapid weak pulse, muscle cramps Treatment: move to cooler location, drink water, take a cool shower or use cold compress -stroke Symptoms: throbbing headache, no sweating, body temp above 103, red, hot, dry skin, n/v, rapid strong pulse, may lose consciousness Treatment: get emergency help, keep cool until treated
72
Trauma triad of death
Coagulopathy, metabolic acidosis, hypothermia
73
What is the antidote for benzodiazepines overdose
Flumazenil
74
Convection, conduction, evaporation
Convection- heat is loss by being exposed to cool air or water Conduction- loss of heat to cold object Evaporation- loss of heat through sweating
75
Clinical manifestations of hypothermia
Myocardial irritability (arrhythmias), bradycardia and altered mental status