Red Blood (RBC) – Erythrocytes Flashcards
- the most numerous blood cell are about one thousand times more numerous than white blood cells
- 7 to 8 micrometers (um) in diameter
- 5.5 million/cu. mm. – male
- 4.9 million/cu. mm – female
- Shape – biconcave disc (7.5 um – 2.0 um)
- Anucleated – no nucleus in the RBC; but during development it will contain nucleus
- Absence of cytoplasmic organelles
- Contains oxygen carrying protein Hemoglobin that gives blood its red color
- Plasma membrane – strong and flexible
- Life span – 120 days
- Old RBC’s are removed by macrophages in spleen
- In the lung’s oxygen binds with heme iron portion to form oxyhemoglobin, when blood reaches the body tissue capillaries, hemoglobin releases oxygen first into interstitial fluid and then to cell for its cellular metabolism.
Red Blood (RBC) – Erythrocytes
➢ a waste product of cellular metabolism from the tissue, will bind with globin to form carbaminohemoglobin. As blood flows to the lungs carbon dioxide is released by hemoglobin and then exhaled.
Carbon dioxide
➢ production of red blood cell
➢ Site of production – Red bone marrow of certain bones
Erythropoiesis
➢ Decreased the blood oxygen stimulates kidney to produce/increase hormone erythropoietin which in turn stimulates red bone marrow to produce/increase RBC and will increase also the blood oxygen.
Hypoxia
➢ mature RBC
Erythrocyte
➢ immature RBC
Reticulocyte
Development Of Blood Cell Stem Cell
- Proerythroblast
- Myeloblast
- Lymphoblast
- Monoblast
- Megakaryoblast
➢ Origin of RBC
Proerythroblast
➢ Production of granulocytes
Myeloblast
➢ Agranular leucocytes
Lymphoblast
Monoblast
➢ Production of platelets
Megakaryoblast
➢ Female = 12-14 gm
➢ Male =14- 16 gm
➢ Male has higher Hgb because testosterone found more in male stimulates synthesis of erythropoietin
Hemoglobin (Hgb)
➢ (to separate) = number of RBC in whole blood
➢ percentage of volume of blood sample occupied by red cells
➢ Supernatant plasma, buffy coat, and packed RBCs
➢ Male = 45 – 52%; Female = 37 – 48%
Hematocrit (Hct)
RBC Disorders:
- Anemia
- Hemophilia
decrease of hemoglobin and hematocrit
Anemia –