Receptors Flashcards
1
Q
General location of α1
A
-Vascular and other smooth muscle, glands
2
Q
Response illicited from α1 receptors
A
-Contraction and secretion from glands
3
Q
Molecular effector systems of α1 receptors
A
- Activate phospholipase C→ ↑IP3 & ↑DAG (↑Ca2+ & PKC)
4
Q
α2 location
A
- Nerve terminals
- Glands
- Vascular smooth muscle
5
Q
α2 respsonse
A
- Decrease NE release
- Decreased secretion
- Contraction
6
Q
α2 molecular system effects
A
- inhibit AC (↓cAMP) - inhibit AC (↓cAMP)
- Activate phospholipase C (via βγ subunits) → ↑IP3 & ↑DAG (↑Ca2+ & PKC)
7
Q
β1 receptor location
A
- Cardiac muscle
- Glands
8
Q
β1 receptor response
A
Increased force and rate of contraction
-Increased secretion
9
Q
β1 molecular effector systems
A
- activate AC (↑cAMP)
10
Q
β2 receptor location
A
- Vascular and other smooth muscle
- Skeletal muscle
- Liver
11
Q
β2 receptor response
A
Vascular and other sm muscle-Relaxation
skeletal msc-Glycogenolysis
liver-Glycogenolysis, gluconeogenesis
12
Q
β2 molecular effector systems
A
- activate AC (↑cAMP)
