Cholinergics: Irreversible Acetylcholinesterase Inhibitors

Question 1

irreversibly phosphorylate seine in substrate binding domaine of AchE

Answer 1

Acetychoinesterase inhibitors

Question 2

regeneration of the enzyme is very slow (several hours) and significant regeneration of
the active enzyme usually is not observed

Answer 2

Acetychoinesterase inhibitors

Question 3

• return of activity depends on synthesis of new enzyme

Answer 3

Acetychoinesterase inhibitors

Question 4

sarin is a

Answer 4

Nerve gases

Question 5

widely employed insecticide; greater safety than parathion because it is
rapidly detoxified in higher organisms

Answer 5

malathion

Question 6

rapidly detoxificed in higher organisms

Answer 6

malthion

Question 7

malthion is an insecticide that is:

Answer 7

Acetychoinesterase inhibitors

Question 8

toxicity by irreversible inhibitors (organophosphate toxicity)

Answer 8

• SLUDGE, hypotension, bradycardia, difficulty with visual accommodation
• also: medullary respiratory center depression, muscle paralysis due to depolarizing
  neuromuscular junction blockade
• death due to respiratory failure
• symptom onset depends on method of exposure (i.e., inhalation, ingestion, topical)

Question 9

Toxic side effect of organosphosphates: medullary respiratory center________, muscle paralysis due to depolarizing

Answer 9

depression

Question 10

Toxic effect of organophosphates: death due to

Answer 10

respiratory failure

Question 11

Treatment from organophosphate poisoning:

Answer 11

• remove source of poisoning
• maintain an open airway and provide artificial respiration if required
• alleviation of convulsions with diazepam
• treatment of shock

Question 12

atropine is a

Answer 12

– (muscarinic receptor antagonist)

Question 13

blocks the peripheral and central muscarinic effects caused by organophosphates

Answer 13

atropine