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Pharm Block 1 > Antibodies > Flashcards

Antibodies Flashcards

1
Q

Monoclonal antiBs are

A

monospecific and identical

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2
Q

All therapeutic antiB’s are

A

IgG

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3
Q

Most of the antibodies have a _______ Fc region and a ________ Fab region

A

human -umab

murine- momab

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4
Q

a mixed human/murine antiB is a

A

chimeric antiB

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5
Q

xi means

A

chimerci

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6
Q

zu means

A

humanized

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7
Q

suffix for all therapeutic antiBs is

A

mab

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8
Q

lim is fot

A

immune system

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9
Q

ci is for

A

cardiovascular

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10
Q

tu is for

A

tumor

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11
Q

vi is for

A

virus

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12
Q

Administration varries and are best given

A

IV

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13
Q

AnitBs are disctibuted

A

extracellularly

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14
Q

AntiB can cross BBB, T/F

A

False, too big

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15
Q

Protects IgG from degredation and proloungs the serum 1/2 life

A

Neonatal Fc REceptor for IgG

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16
Q

Helps transfer passive immunity to fetus

A

Neonatal Fc Receptor for IgG

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17
Q

What pH does FcRn bind the Fc regsion of IgG at?

A

pH lower then 6.5 so releases as 7.4

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18
Q

do murine IgG bind human FcRn?

A

no they don’t

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19
Q

Fab antiB fragrements lacking Fc region will

A

not bind to FcRn

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20
Q

This protects the antiB from degredation once it’s taken up into a cell

A

Neonatual Fc Receptor

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21
Q

Half life of IgG1, IgG2, IgG4 is

A

long or about 21 days

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22
Q

IgG3 half life it

A

7 days

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23
Q

antibody fragments Fab have T=1/2 of

A

.5-21 hours, very short

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24
Q

These cells have Fc receptors that can bind and causes endocytosis of IgG

A

phagocytic cells in target tissue

25
Q

What is the function of renal and biliribin in degredation of antibodies?

A

unimportant

26
Q

Uses for Monoclonal aniB therapy

A 
immunosuppression
Autoimmune
malignancies
infectious diseas
asthma
27
Q

Direct affect of antiBs on antiG

A

antagonism or neutralization

28
Q

AntiB will bind and inactivate a

A

soluble antiG

29
Q

Anitbody acts as competitive inhibitor of ligand by

A

binding to cellular recpetor

30
Q

Blocking this guy will block neurovasculation

A

blocking VEGF

31
Q

Blocking VEGF is good for

A

reducing vascularization of tumors

32
Q

use to tx metastatic colorectal cancer, pancreatic cancer or breast and prostate carcinoma

A

VEGF blockig by antiB

33
Q

This method of antiB binds and inhitibts EGF receptor to inhibit tumor growth

A

EGF

34
Q

This antiB targets ______ to stop head and neck or colorectal cancer

A

EGF

35
Q

By binding and inhibiting the EGF receotpr, the antiB is

A

inhibiting signaling

36
Q

When would a Chimeric Fab fragment be useful

A

if we just want a short durationg of action

37
Q

This is good for platele aggregation and inhibits fibrinogen

A

Chimeric Fab fragmet of mAb

38
Q

therapies for Fab fragrment of mAG

A

acute coronary syndrome of percutaneous coronary intervention

39
Q

By binding to the Fc Receptor on NK cell, the monoclonal anitB will activated

A

Anti-body dependent cellular cytotoxicity

40
Q

Rituximab will bind to protein:

A

CD20

41
Q

whhat is the significance of binding to CD20 on cell surface of B cells

A

causes B cell lysis when we have leukimic or lymphoma

42
Q

CDC stands for

A

complement dependent cytotoxicity

43
Q

AntiB bind to cell surface and Fc region binds to

A

complement protein to activate CDC

44
Q

What is the result of CDC

A

cell lysis

45
Q

What is a benefit of binding to or inhibiting EGF

A

we block EGF, get ACDD and CDC and inhibut tumor growth

46
Q

To turn on antibody dependent cellular cytotoxicity (ADCC) we will activate which little guy

A

C3d

47
Q

Selective delivery of toxins or radio nucleotides work by:

A

antiB-toxin –> antiB binds to target and is internalized–> toxin released

48
Q

CD30 is a good target for Fab regions to bind to because

A

CD30 is not in normal cells but is expresed in lyphoma

49
Q

CD30 specific antiB will also bring this along to release in these cells

A

microuble toin monomtl auristatin E or MMAE t

50
Q

microtublue toxin-monomethy auristatin E is good for

A

bringing along with CD30 specific IgG because it will stop cell proliferation

51
Q

A CD30 specific drug

A

Bretuximab vedotin

52
Q

Bretuximab Vedotin works by

A

Cd3 speficif, has MMAE that stops cell porliferation and then promotes cellylar cytotoxicity and Anitbody dependendt cellular cytotoxicity

53
Q

Ibritumomab tiuxetan Y labled antiB works agains what membrane protein

A

CD20

54
Q

CD20 is on :

A

B cells

55
Q

CD20 on B cells is targeted by

A

Ibritumomab that has a conjgated radioative Y

56
Q

are monoclonal antiB well tolerated

A

yes…. generally safe

57
Q

What are some side affects of this tx

A

mechanism specific, if tartes plateltes at risk for bleeding

if VEGF speciic, you can get tumor lysis syndrome or slow wound healing

58
Q

The longer you tx with an immungenticy drug class

A

you lose the effect the the thearpy

59
Q

Negative affect of antiB that triggers release of a variety of cytockines

A

cytokine storm

Pharm Block 1 (23 decks)

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