Antibodies Flashcards
Monoclonal antiBs are
monospecific and identical
All therapeutic antiB’s are
IgG
Most of the antibodies have a _______ Fc region and a ________ Fab region
human -umab
murine- momab
a mixed human/murine antiB is a
chimeric antiB
xi means
chimerci
zu means
humanized
suffix for all therapeutic antiBs is
mab
lim is fot
immune system
ci is for
cardiovascular
tu is for
tumor
vi is for
virus
Administration varries and are best given
IV
AnitBs are disctibuted
extracellularly
AntiB can cross BBB, T/F
False, too big
Protects IgG from degredation and proloungs the serum 1/2 life
Neonatal Fc REceptor for IgG
Helps transfer passive immunity to fetus
Neonatal Fc Receptor for IgG
What pH does FcRn bind the Fc regsion of IgG at?
pH lower then 6.5 so releases as 7.4
do murine IgG bind human FcRn?
no they don’t
Fab antiB fragrements lacking Fc region will
not bind to FcRn
This protects the antiB from degredation once it’s taken up into a cell
Neonatual Fc Receptor
Half life of IgG1, IgG2, IgG4 is
long or about 21 days
IgG3 half life it
7 days
antibody fragments Fab have T=1/2 of
.5-21 hours, very short