Pharmakokinetics Flashcards
1
Q
lipids diffuses easily via:
A
passive diffusion
2
Q
Passve diffusion determined by what 2 factors
A
partition coefficient
concentration gradient
3
Q
Weak acids: form that will passively diffuse
A
HA form bc not charged
4
Q
When hydrogen conc is high, what form of weak acid predominates
A
HA
5
Q
[HA]/ [A-] determined by what two factors
A
pH of environment and pKa of drug
6
Q
pKa of molecule here has pH where we are 50% protonated, 50% deprotonated
A
Inflection point
7
Q
When can a weak base pass the membrane
A
when pH is high and there is a low conc of H+
8
Q
in the concept of ion trapping,
acidic drugs get trapped:
basic drugs get trapped:
A
more basic side, higher pH
more acidic side, lower pH
