Receptor theory Flashcards
1
Q
Describe how fluoxetine acts as an SSRI?
A
blocks reuptake of seratonin in the presynaptic membrane
2
Q
What are the 4 receptor superfamilies?
A
Ionotropic
Metabotropic
Tyrosine kinase
DNA linked
3
Q
What are features and examples of ionotropic channels?
A
- fast (millisecs)
- eg nicotinic acetylcholine receptor
4
Q
What are features and examples of Metabotropic channels?
A
- G protein coupled
- medium speed
- eg histamine receptor
5
Q
What are features and examples of tyrosine kinase receptors?
A
- medium speed (secs to mins)
- eg insulin receptor
6
Q
What are features and examples of DNA linked receptors?
A
- slow (hours)
- eg glucocorticoid receptor
7
Q
What are the subunits of G proteins?
A
- alpha
- beta
- gamma
8
Q
What does Gs do?
A
- stimulate adenylate cyclase,
- increase cAMP production, PKA activation
9
Q
What does Gi/o do?
A
- inhibit adenylate cyclase, decrease cAMP production
- beta-gamma subunit inhibit calcium channels and activate potassium channels
10
Q
What does Gq do?
A
- stimulate phospholipase C, increase IP3 and diacylglycerol
- lead to PKC activation and calcium release from ER
11
Q
What activates tyrosine kinase?
A
- growth factors
- cytokines
- hormones
12
Q
How do DNA-linked receptors work?
A
- When ligand binds move to nucleus
- Activate or inhibit gene transcription
- Activated by hormones
