Quiz 5 study guide Flashcards
What is blood collected directly from a donor into a blood transfusion bag containing anti-coagulant
Fresh Whole Blood
What does Fresh whole blood contain?
RBC WBC Platelets All coagulation factors Albumin Globulin
How long can you store fresh whole blood?
Room temperature for up to 8 hours
What is blood collected directly from a donor into a blood transfusion bag containing anti-coagulant and put in the refrigerator
Stored Whole blood
What does stored whole blood contain?
RBC WBC All coagulation factors but less Albumin Globulin
What does stored Whole Blood not contain
Platelets
How long can you store stored whole blood?
Refrigerator for up to 28 days
What is whole blood spun down with the plasma removed?
Packed Red Blood Cells
What does Packed Red Blood cells contain?
RBC
WBC
What does Packed Red Blood cells not contain?
Platelets
Coagulation factors
Proteins
What is the main indication of Packed Red blood cells?
Anemia
Replaces RBCs
What does plasma contain?
All coagulation factors
Albumin
globulin
What is the most commonly used form of plasma?
Fresh Frozen plasma
How long does liquid plasma last?
14 days in the refigerator
How long does fresh frozen plasma last?
Up to 1 year
How long does frozen plasma last?
Up to 5 years
Why do we give plasma?
To replace coagulation factors and or proteins
In what conditions do we give plasma for?
Anti-coagulant rodenticide toxicity Congenital Disease DIC Von Willebrans Hypoproteinemia
What is the bad stuff that can happen when blood products are given
Destroy patient's red blood cells Develop fever Develop hives Fluid in the lungs Sepsis Circulatory Overload Hypocalcemia/Citrate Overload Hyperammonemia Infectious disease
Why is blood typing is important?
An immune reaction can occur
What does DEA stand for?
Dog Erythrocyte Antigen
What is the most important blood type in a dog?
DEA 1
There is no true universal donors in dogs or cats. What would a true universal donor be?
Negative for all the antigens or only have antigens that 100% of the other dogs have
DEA 4+ is the best for dogs, but what is the most practical?
DEA 1 negative
What does Canine In-House Blood Type Testing use?
Antibodies to test for the presence of specific red blood cell antigens
Who can get DEA 1+ blood?
DEA 1+ recepient
Who can not get DEA 1+ blood
DEA 1-
Who can get DEA 1- blood?
Both DEA 1+ and DEA 1-
What are the three blood types in cats?
A-most common
B-less common
AB-rare
Why is blood typing a cat important?
Need to administer Type-specific blood
What happens if you give A type blood to a B type cat?
Acute hemolysis and Death
What is cross-matching?
Testing for a reaction in the lab before a reaction occurs in the actual patient
Setting up pRBC transfusions
Use a blood administration set with in-line filter
Gravity for dogs
Don’t give IV meds during transfusion unless there is another IVC
Can use a syringe pump for cats with a HemoNate filter
Why are syringe pumps and most fluid pumps not used in dog transfusions?
Because they will injure dog RBCs
You monitor a transfusion patient every 15 minutes, what vitals are you monitoring?
Temperature Pulse RR Vomiting Discolored urine
What are the types of Hypotonic cystalloids?
5% dextrose
0.45% NaCl
Normosol M
Plasmalyte 56
What are the types of Isotonic crystalloids?
0.9% NaCl
Normosol R
Plasmalyte 148
LRS
What are examples of Hypertonic crystalloids
3% and 7% saline
What are types of colloids?
Hetastarch
Vetstarch
Dextran 70
What type of fluid is similar to Extra cellular fluid?
Crystalloid fluids
What do crystalloids contain
Less sodium and chloride
More potassium
Lower concentration of buffer
Dextrose
What is used to support blood volumes and blood pressure, stays primarily in the intravascular space
Colloids
What formulas are used when calculating maintenance rates of crystalloid fluids
40-60 ml/kg/day
30ml/pound/day
30 x kg +70
2-4 ml/kg/hour
What does the maintenance phase of fluids meet the daily loss of?
Urination
GI system
Panting
What is the fluid calculation for routine anesthesia?
10 mL/kg/hr for the 1st hour
3-5 mL/kg/hr during the remainder of the procedure
If there is excessive hemorrhage or hypotension what is the fluid rate calculation?
40 mL/kg/hr in dogs
20 mL/kg/hr in cats
What is the shock fluid rate calculation
90 mL/kg/hr in dogs
55 mL/kg/hr in cats
What is the fluid calculation for shock and blood loss
3-4 mL/kg of 7% hypertonic saline over 5 minutes
What is the colloid fluid rate calculation in dogs and large animals?
10-20 mL/kg/day
What is the colloid fluid rate calculation for cats?
5-10 mL/kg/day
How is morphine administered?
IV IM SC Intra-articular Epidural
What is the mechanism of action of morphine?
Pure agonists with affinity for mu and kappa opioid receptors
What does morphine cause?
Excitement or dysphoria
Restlessness
What are some adverse side effects of morphine?
GI stimulation in dogs & cats Ileus & colic in horses Excitement miosis (dogs) mydriasis (cats) Hypothermia hyperthermia (cats) Bradycardia Panting increased intraocular pressure urinary retention
How is oxymorphone administered?
IV
IM
SC
Epidural
What is the mechanism of action of Oxymorphone?
Pure opioid agonist
Greater potency & sedative effects than morphine
Fewer side effects & longer duration of effect than morphine
How is Hydromorphone administered?
IV
IM
SC in dogs & cats
What is the mechanism of action of Hydromorphone?
Opioid agonist
Less potency but similar duration of effect compared with oxymorphone
What does a full opioid agonist do?
Full activity of channel
What does a partial opioid agonist do?
Reduced activity of channel
What does an opioid antagonist do?
Prevents activity of channel
What does an opioid agonist-antagonist do?
Agonist at one receptor but an antagonist at another receptor
What is an example of a pure antagonist and what does it do?
Naloxone and it fully reverses the effects of opioids
What is an example of a mixed agonist-antagonist
Butorphanol
Mixed agonist at the kappa receptor
Antagonist at the mu receptor
Will partially reverse the effects of the pure agonists
What is the most potent analgesics known and has a rapid onset of 2 minutes?
Fentanyl
How is Fentanyl administered?
Continuous IV drip Transdermal patch IM SC Epidural
What is the mechanism of action of Butorphanol?
Stimulates kappa receptors Blocks mu receptors Not as effective as an analgesic Produces less sedation & respiratory depression Used to reverse morphine & fentanyl
How is butorphanol administered?
IV
IM
SC
Orally
What is the mechanism of action of Buprenorphine?
Partial mu agonists
Produces some analgesia for mild to moderate pain
Can be used to reverse morphine & fentanyl
Delayed onset of action & longer duration of analgesia
How is Buprenorphine administered?
IV
IM
Epidural
Orally to cats
What is the newer combination of buprenorphine?
Simbadol
What is a synthetic opioid with characteristics similar to oxymorphone and hydromorphone?
Methadone
What is the mechanism of action of methadone?
Antagonist at the NMDA receptor
What is another pure opioid agonist with less potent analgesic properties and shorter duration of action?
Merperidine/Pethidine
How is Meperidine/Pethidine administered?
SC injection
What is Meperidine/Pethidine used in combination with?
Atropine or acepromazine
What is the drug of choice for Intra-articular injection?
Morphine
Where is an epidural injection commonly given?
Lumbosacral junction
What does an epidural injection provide?
Analgesia to: Hind limbs Abdomen Caudal thorax Pelvis Tail
What is the most commonly used drug for epidurals?
Morphine
What is the mechanism of action of NSAIDs
Inhibit prostaglandin synthesis by inactivating COX iosenzymes
What kind of pain are NSAIDs and what is the onset of action?
Somatic & Visceral pain
30-60 minutes
What do NSAIDs prevent the production of?
Beneficial prostaglandins along with the production of prostaglandins that mediate pain, inflammation, fever
Which NSAID produces the least adverse side effects?
COX-2 enzyme inhibitors
What are the adverse side effects of NSAIDs?
Stomach ulcers Vomiting GI bleeding Lack of appetite Renal toxicity Impaired platelet aggregation Liver damage
Repeated use of what NSAID causes acute renal failure and death?
Meloxicam
What is a new NSAID to be used in cats that is safer?
Onsior or Robenacoxib
COX-2 selective NSAID
How is Onsior administered?
Injection
Orally
What is a newer NSAID that is used in Dogs
Galliprant
What is the mechanism of action for Galliprant?
First-in-class prostaglandin receptor antagonist
Non-COX inhibiting
Specifically targets the EP4 receptor
What has a profound sedative effect, produces significant analgesia via epidural route and can be reveresed?
Alpha-2 Adrenoceptor Agonists
What drug can be used as an adjunct to more potent analgesics but does not produce great analgesia by itself?
Ketamine
What is the mechanism of action of Ketamine?
Blocks NMDA receptors at the level of the spinal cord to prevent windup
What has strong anti-inflammatory properties, decrease prostaglandins but can not be used concurrently with NSAIDS?
Corticosteroids
Why should Corticosteroids not be used with NSAIDs?
Because there is a dual effect of negative adverse reaction.
What is a non-opiate drug, has activity at the mu receptor, inhibits the reuptake of norepinephrine and serotonin?
Tramadol
What was initially used as an anticonvulsant, useful for chronic pain, can have strong sedative effects?
Gabapentin
Good option for cats
Do tranquilizers have analgesic properties?
NO but can be combined
What are tranquilizers useful for?
Calming the excitement sometimes seen in cats and horses
Keys to Great Pain Management
Preemptive analgesia Multimodal pain management Observe for and know the signs of pain Nursing care Nonpharmacologic treatment Client education
What is the key to successful analgesia in patients?
Preemptive Analgesia
What does preemptive analgesia consist of?
Administration of pain medication before the pain occurs
Commonly involves adding analgesic to premedication prior to anesthesia
Reduces overall requirement for analgesia and duration of administration
Prevents windup
Multimodal Therapy
Use of more than one type of analgesic to relieve pain
Fentanyl & meloxicam
Morphine & injectable NSAID
MLK
Nursing Care
Relieving patient discomfort will help pain control
Nonpharmacologic Therapies
Used in conjunction with or as an adjunct to pharmacological therapy
Laser therapy (Photobiomodulation)
Alters the inflammatory response and affects cell signaling
What are the benefits of Laser Therapy?
Pain reduction Decreased inflammatory markers in joints Reduced swelling and edema Increased mobility (joint) and function Stimulation of collagen synthesis
The HHHHHMM Quality of Life Scale.
Hurt Hunger Hydration Hygiene Happiness Mobility More good days than bad
What exercises help a patient develop better awareness of where his or her body is?
Proprioceptive exercises
What benefits does walking on an underwater treadmill provide?
Increased joint range of motion
Improved muscle flexibility and mobility
Enhanced circulation
Facilitation of front to rear and side to side balance
What relieves pain and increases muscle strength while putting decreased weight on the joints
Hydrotherapy
Under-water therapy
What benefits does hydrotherapy provide to neurologic patients?
Many patients can take steps in water before they can perform voluntary motion on land
What is a systemic and scientific manipulation of soft tissues of the body for the purpose of obtaining or maintaining health?
Massage
What is the use of stretching to prevent the loss of normal range of motion, to return normal range of motion if absent, to increase cartilage nutrition to the joint, and to stimulate cartilage regeneration?
Passive Range of Motion
What is the application of electrical current to elicit a muscle contraction?
Neuromuscular electrical stimulation
What is the main purpose of Neuromuscular electrical stimulation?
to attain muscle strengthening
What are the clinical uses of Neuromuscular electrical stimulation?
Reducing disuse atrophy
Reversing muscle atrophy
Strengthening selected muscles
What are the contraindications of Neuromuscular Electrical Stimulation?
Over heart or cardiac pacemakers
Use on animals with seizure disorders
Over area of peripheral vascular disease or thrombophelbitis
Over areas of decreased pain/temperature sensation
Over infection
Over neiplasms
Over the carotid sinus
Any time active motion is contraindicated
What is the use of sound waves to treat tissue?
Therapeutic Ultrasound
What is the value of therapeutic ultrasound?
Increased collagen extensibility Increased blood flow Increased range of motion due to changes in contractility of muscle Decreased pain and muscle spasm Increased enzyme activity Changes in nerve conduction velocity Accelerated wound healing due to facilitation of the inflammatory process Enhanced transdermal delivery
What are the clinical applications of Therapeutic Ultrasound?
Joint contracture and scar tissue Tendonitis and bursitis Pain and muscle spas, Wound healing Calcium reabsorption Chronic wounds
What is the stimulation of tissue with low-energy lasers to achieve therapeutic effects?
Low-Level laser therapy
What are common indications for Low-level laser therapy?
Treating pain associated with degenerative joint disease and intervertebral disc deisease Postoperative pain Soft tissue injuries Stimulate healing of wounds and ulcers Stimulate acupuncture points relieve trigger points
What does LLLT reduce?
Edema
Stomatitis
Gingivitis
Temporomandibular joint dysfunction
What are the advantages of Cryotherapy?
Vasoconstriction (reduces postsurgical bleeding and brusing)
Slows nerve conduction (decreasing the pain sensation)
Decreases Enzyme activity (Decreasing inflammation)
What allows reconstruction of the disturbed electrical field?
Pulsed electromagnetic field therapy
What are the benefits of Pulsed Electromagnetic Field Therapy?
Returns the natural regeneration capabilities and reactivates the chondrocytes and connective tissue to increase production of proteoglycan and collagen
Repairs tendons and ligament injuries
When should Pulsed electromagnetic field therapy not be used?
For partial cranial cruciate tears because it removes the early scar tissue critical for stabilization
What is transcutaneous electrical nerve stimulation used for?
Treating deep, aching, and chronic pain
What is the technician’s role in transcutaneous electrical nerve stimulation?
Shave if needed
Apply gel and pads
Setting the machine to the proper frequency and intensity
What exercises involve posture and gait correction that vary in the degree of therapist assistance?
Neuromuscular Re-education
What is the general rule of Neuromuscular re-education?
The patient is asked to do as much as physically possibe and the therapist assists as needed to attain correct posture and gait