Quiz 2

Question 1

Antiplatelet Factors Secreted by ____ ? Promote ____? Inhibit _______ ?

Answer 1

Endothelial Cells Vasodilation Platelet adhesion and aggregation

Question 2

Prostacyclin PGI2 Signal with _____ Opposes the effects of _____?

Answer 2

cAMP TXA2

Question 3

Nitric Oxide signals with_____?

Answer 3

cGMP-vasodilation

Question 4

What are the 4 antithrombotic activities?

Answer 4

• Heparan sulfate anchors Antithrombin III (ATIII) - ATIII inactivates Xa, IXa, XIa, and XIIIa - Tissue factor pathway inhibitor (TFPI) - Thrombin-thrombomodulin complex activates protein C (C) + Protein C and protein S cleave Va, VIIIa and activate t-PA

Question 5

Antithrombin III Looks like _____? Is a ______ of serine proteases including these 5 clotting factors

Answer 5

Inactive clotting factors - It is a suicide substrate Thrombin, IX, X, XI, XII

Question 6

Antithrombin is clinically activated by ____ what medicine?

Answer 6

Heparin - Indirect

Question 7

Tissue factor pathway inhibitor does what?

Answer 7

Blocks Tissue factor which blocks the whole pathway

Question 8

What protein complex inactivates the inhibitor of t-PA

Answer 8

Protein C/S

Question 9

What does t-PA do? What is the end result?

Answer 9

Turns Plasminogen into plasmin Result is digestion of fibrin clot

Question 10

Only one type of heparin can inhibit II

Answer 10

Unfractionated heparin

Question 11

Thrombomodulin—-> _____——>_______ —–>______? Activates _____ —- _____? This is called?

Answer 11

Thrombin APC/PS complex t-PA Plasminogen —-> Plasmin Fibrinolysis

Question 12

t-PA can be activated by both _____ and _____

Answer 12

Protein C/S complex and fibrin

Question 13

What are the Antiplatelet drugs

Answer 13

• Aspirin - Clopidogrel -Dipyridamole (increases cAMP, and cGMP) -Abciximab, eptifibatide, tirofiban GPIIb,a blockage

Question 14

What are the anticoagulant drugs?

Answer 14

Heparins DTIs Warfarin Factor Xa inhibitors

Question 15

Unfractionated heparin works against?

Answer 15

Factor X and factor II Can cause HIT

Question 16

Pentasaccharide, and low molecular weight heparindont act on? What is the reeason for this?

Answer 16

Factor II thrombin reduce the risk of HIT Indirect through antithrombin III

Question 17

Warfarin Induces ____ deficiency?

Answer 17

Vitamin K deficiency

Question 18

What is the target of warfarin?

Answer 18

Epoxide Reductase

Question 19

Warfarin has delayed _____ and ______

Answer 19

Onset and off set, Teratogenic

Question 20

What are the two tests that need to be done when a patient is on Warfarin? When do these tests need to be done?

Answer 20

Prothrombin Time ( Before and after taking) International Normalized Ratio - Pt is converted into this through division

Question 21

Activated partial thromboplastin time deals with what meds?

Answer 21

Heparin, also helpful in diagnosis of hemophilia

Question 22

If someone takes too much warfarin what do you do?

Answer 22

Vitamin K

Question 23

Apixaban is a ______

Answer 23

Direct factor Xa inhibitors

Question 24

Rudins are? Monitored by?

Answer 24

Direct thrombin inhibitors Monitored by aPTT same as Heparin

Question 25

Plase drugs do what?

Answer 25

Activate plasminogen to plasmin

Question 26

What are the adverse effects of Recombinant tissue-plasminogen activators?

Answer 26

Cardiac Arrythmias Intracranial, GI bleeding Cholesterol Embolization

Question 27

What are the contraindications for Fibrinolytic therapy?

Answer 27

-Prior intracranial hemorrhage - Known structural cerebral vascular lesion - Known malignant intracranial neoplasm - Ischemic stroke within 3 months -Active bleeding or bleeding diathesis - Closed head trauma or facial trauma within

Question 28

Heparin is reversed by?

Answer 28

Proxamine

Question 29

Dipyridamole

Answer 29

Inhibits reuptake of adenosine and inhibits phosphodiester that degrades cAMP

Question 30

Direct oral Factor Xa inhibitors?

Answer 30

xabans A fib - Cant be reversed

Question 31

Plase

Answer 31

Drugs that activate tissue plasminogen to create plasmin Given soon after event