Drugs

Question 1

Rimantadine is poor at crossing the? and has less what?

Answer 1

BBB CNS effects

Question 2

Warfarin

MOA

how to monitor

AE

Answer 2

• Inhibits vitamin K epoxide reductase
• Teratogenic-fetal hemorrhage

Question 3

Dipyridamole

Answer 3

• Inhibits reuptake of adenosine and inhibits phosphodiester that degrades cAMP
• Contraindicated in CHF

Question 4

Nonnucleotide RTI are different than side and tide inhibitors in what way?

Answer 4

Dont require phosphorylation

Dont compete with dNTPs

Resistance develops rapidly

Question 5

Activated partial thromboplastin time deals with what meds?

Answer 5

Heparin, also helpful in diagnosis of hemophilia

Question 6

What does amantadine block?

Answer 6

Blocks the M2 proton ion channel

Question 7

Rudins are? Monitored by?

Answer 7

Direct thrombin inhibitors Monitored by aPTT same as Heparin

Question 8

Direct oral Factor Xa inhibitors?

Answer 8

xabans A fib - Cant be reversed

Question 9

Tenofovir inhibits?

Answer 9

viral reverse transcriptase DNA chain terminator

Question 10

Clopidogrel

MOA

DI

Answer 10

• Irreversible inhibition of platelet ADP receptor
• Bleeding GI

Question 11

Zidovudine ZDV or AZT

AE

Answer 11

• Bone marrow toxicity causing anemia
• Lactic acidosis

Question 12

If someone takes too much warfarin what do you do?

Answer 12

Vitamin K

Question 13

Heparin is reversed by?

Answer 13

Proxamine

Question 14

Rimantadine is a?

Answer 14

Uncoating inhibitor

Question 15

Apixaban is a ______

Answer 15

Direct factor Xa inhibitors

Question 16

Oseltamivir is a?

Answer 16

Inhibitor of influenza neuraminidase oral

Question 17

Nucleoside RT inhibitors need to be activated by?

Answer 17

• Need to be activated within the cell by phosphorylation

Question 18

Clopidogrel

Answer 18

• Irreversible inhibition of platelet ADP receptor
• Bleeding, GI

Question 19

Tenofovir?

Answer 19

Nucleotide RTI

Question 20

Plase

Answer 20

Drugs that activate tissue plasminogen to create plasmin Given soon after event

Question 21

Rimantadine is ___ compared to amantadine

Answer 21

longer lived

Question 22

Plase drugs do what?

Answer 22

Activate plasminogen to plasmin

Question 23

Nevirapine, delavirdine and efavirenz are?

MOA

AE

Answer 23

• NNRTI
• They are not active against HIV-2
• NNRTIs bind directly noncompetitively to the RT enzyme at a site distinct from NRTI binding site
• Block DNA polymerase by causing a conformational change and disrupt the catalytic site of the enzyme

Question 24

Tipranavir

Answer 24

• Antiretroviral protease inhibitor
• non-peptidic protease inhibitor
• AE
  
  • Dose-dependent hepatotoxicity, lipodytrophy

Question 25

Nucleotide RTI differ from nucleoside analogs in what way?

Answer 25

They are already phosphorylated so they can skip the nucleoside-kinase reaction

Question 26

Zidovundine ZDV or AZT is a? Nucleoside ot tide?

Answer 26

NRTI

Question 27

How do nucleoside reverse transcriptase inhibitors cause termination of viral growth

Answer 27

* The lack of 3'-OH analog prevents the formation of the 5' to 3' phosphodiester linkage needed for chain elongation

Question 28

Integrase inhibitors?

Answer 28

Raltegravir, prevent virus DNA from integrating into host genome

Question 29

Aspirin MOA Drug interactions and AE

Answer 29

* Irreversible COX1 inhibitor Reduces the production of thromboxane A2 * Can cause nephrotoxicity

Question 30

Ritonavir? MOA DI AE

Answer 30

* Antiretroviral protease inhibitor * Competitive inhibitor of HIV protease responsible for cleaving gag-pol precursor molecule * Inhibit both HIV-1 and 2 DI * Ritonavir is a substrate and potent inhibitor of CYP3A4 * Can act as a pharmacokinetic enhancer of drug metabolized by CYP450 3A AE * Hyperlipidemia, with large increases in total cholesterol and TG concentrations

Question 31

Abciximab MOA AE DI

Answer 31

* Inhibits platelet aggregation by interfering with GPIIb/IIIa binding to fibrinogen and other ligands * Bleeding thrombocytopenia with prolonged use

Question 32

Oseltamivir blocks?

Answer 32

Neuraminidase

Question 33

Lamivudine 3TC As well as being used for HIV can also inhibit replication of? Side or tide?

Answer 33

NRTI HBV

Question 34

Maravoroc?

Answer 34

HIV entry inhibitor that stops binding with CCR5 receptor - Can interfere with immune response, not effective at all with CXCR4 because CCR5 isnt used