Quick facts 3 Flashcards
Which chemotherapy drug would cause Pulmonary Fibrosis?
Capecitabine
Bleomycin
Doxorubicin
Imatinib
Which chemotherapy drug would cause Pulmonary Fibrosis?
Capecitabine
Bleomycin
Doxorubicin
Imatinib
Bcl2 causes what type of gain of function mutation?
Point mutation of non-coding region: promotor/enhancer region
Point mutation of coding region
Gene amplification
Translocation / transposition
Which type of cancer is this seen in?
Translocation / transposition: induction blocks apoptosis (anti-apoptotic gene).
Overexpression by (t14:18) (q32; 21).
Leads to follicular lymphoma
The patient is referred to haematology and a diagnosis of chronic myeloid leukaemia is made.
Which of the following medications has dramatically improved prognosis in recent years?
Infliximab
Imatinib
Vincristine
Rituximab
The patient is referred to haematology and a diagnosis of chronic myeloid leukaemia is made.
Which of the following medications has dramatically improved prognosis in recent years?
Infliximab
Imatinib
Vincristine
Rituximab
which of the following form hemorrhagic cystitis as a side effect?
alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors
which of the following form hemorrhagic cystitis as a side effect?
alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors
Q
Which of the following binds to CTLA4?
Tisagenlecleucel (Kymriah)
Atezolizumab
Rituximab
Ipililumbab
Nivolumab
Q
Which of the following binds to CTLA4?
Tisagenlecleucel (Kymriah)
Atezolizumab
Rituximab
Ipililumbab
Nivolumab
In the context of a diagnosis of prostate cancer, metastatic spinal cord compression needs to be ruled out with an
CT spine
CT brain
PET scan
MRI spine
In the context of a diagnosis of prostate cancer, metastatic spinal cord compression needs to be ruled out with an
CT spine
CT brain
PET scan
MRI spine
Which of the following is the most important buffer system in the blood?
Ammonium buffer system
Carbonic acid-bicarbonate buffer system
Haemoglobin buffer system
Phosphate buffer system
Plasma proteins buffer system
Which of the following is the most important buffer system in the blood?
Ammonium buffer system
Carbonic acid-bicarbonate buffer system
Haemoglobin buffer system
Phosphate buffer system
Plasma proteins buffer system
What drug class are:
* Irinotecan
* Topotecan
Topoisomerase-I inhbitors
Unexplained Over 60 & IDA might indicate? [1]
Colorectal cancer
Which of the following is topoisomerase II inhibitor which is cardiotoxic and cause dilated cardiomyopathy
Irinotecan
Topotecan
Doxorubicin
Epirubicin
Which of the following is topoisomerase II inhibitor which is cardiotoxic and cause dilated cardiomyopathy
Irinotecan
Topotecan
Doxorubicin
Epirubicin
B-Raf is an oncogene that belongs to
Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins
B-Raf is an oncogene that belongs to
Growth factor receptors
Signal transduction proteins
Transcription factors
Anti-antopic proteins
This protein plays a role in regulating the MAP kinase/ERKs signaling
The majority of humanised monoclonal antibodies use which Ig as a backbone?
IgA
IgD
IgE
IgG
IgM
The majority of humanised monoclonal antibodies use which Ig as a backbone?
IgA
IgD
IgE
IgG
IgM
which of the following work by integrating into host DNA / RNA and inhibiting replication
alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors
which of the following work by integrating into host DNA / RNA and inhibiting replication
alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors
c-fos causes what type of gain of function mutation?
Point mutation of non-coding region: promotor/enhancer region
Point mutation of coding region
Gene amplification
Translocation / transposition
Which type of cancer is this seen in?
c-fos causes what type of gain of function mutation?
Point mutation of non-coding region: promotor/enhancer region
Point mutation of coding region
Gene amplification
Translocation / transposition
Which type of cancer is this seen in?
Ras mutation is most associated with which type of cancer?
Non-small cell lung cancer
Colon cancer
Pancreatic cancer
Papillary thyroid cancer
Ras mutation is most associated with which type of cancer?
Non-small cell lung cancer
Colon cancer
Pancreatic cancer
Papillary thyroid cancer
Most common form of radiotherapy are the [], which are used to treat deeper cancers.
Most common form of radiotherapy are theMV photons, which are used to treat deeper cancers.
Methotrexate inhibits which of the following
G1
S
G2
M
Methotrexate inhibits which of the following
G1
S
G2
M
paclitaxel & docetaxel inhibit which cell cycle stage
G1
S
G2
M
paclitaxel & docetaxel inhibit which cell cycle stage
G1
S
G2
M
Cancers are initiated and progress by mutations in genes which result in either a gain or loss of function.
Which of the following best describes the gain of function mutation observed in lung adenocarcinoma?
Mutation in CDKN2A (cyclin dependent kinase inhibitor)
Mutation in Rb (retinoblastoma protein)
Mutation in EGFR (epidermal growth factor receptor)
Mutation in MYC
Mutation in TP53 (tumour protein 53)
Cancers are initiated and progress by mutations in genes which result in either a gain or loss of function.
Which of the following best describes the gain of function mutation observed in lung adenocarcinoma?
Mutation in CDKN2A (cyclin dependent kinase inhibitor)
Mutation in Rb (retinoblastoma protein)
Mutation in EGFR (epidermal growth factor receptor)
Mutation in MYC
Mutation in TP53 (tumour protein 53)
Which drug is prescribed if a mutation to a tyrosine kinase receptor in small cell lung cancer occurs
Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla
Which drug is prescribed if a mutation to a tyrosine kinase receptor in small cell lung cancer occurs
Trastuzumab
Pertuzumab
Osimertinib
Erlotinib
Kadcycla
Which of the following is derived from E. coli and deprives tumour cells of the required amino acids and inhibits protein synthesis
Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan
Which of the following is derived from E. coli and deprives tumour cells of the required amino acids and inhibits protein synthesis
Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan
Which type of surgical treatment would be used for the removal of lymph nodes and an organ/s
Local resection
Radical resection
Supra-radical resections
Surgery for metastasis/recurrence
Surgical management of complications
Which type of surgical treatment would be used for the removal of lymph nodes and an organ/s
Local resection
Radical resection
Supra-radical resections
Surgery for metastasis/recurrence
Surgical management of complications
Which of the following binds to the minor groove of DNA, bending the helix towards the major groove, which leads to interference with the intracellular transcription pathways and DNA-repair pathways
Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan
Which of the following binds to the minor groove of DNA, bending the helix towards the major groove, which leads to interference with the intracellular transcription pathways and DNA-repair pathways
Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan
Caspases are proteins that initiate and execute the process of apoptosis in cells.
Which of the following caspase proteins is essential to initiate apoptosis through the extrinsic pathway?
Caspase 3
Caspase 6
Caspase 7
Caspase 8
Caspase 9
Caspases are proteins that initiate and execute the process of apoptosis in cells.
Which of the following caspase proteins is essential to initiate apoptosis through the extrinsic pathway?
Caspase 3
Caspase 6
Caspase 7
Caspase 8
Caspase 9
Tremelimubab binds to which of the following
PDL1
PDL2
CTLA4
PD1
Tremelimubab binds to which of the following
PDL1
PDL2
CTLA4
PD1
Which chemotherapy drug would cause Peri-Orbital Oedema?
Capecitabine
Bleomycin
Doxorubicin
Imatinib
Which chemotherapy drug would cause Peri-Orbital Oedema?
Capecitabine
Bleomycin
Doxorubicin
Imatinib
Q
Which chemotherapy drug would cause Flagellate Erythema ?
Capecitabine
Bleomycin
Doxorubicin
Imatinib
Q
Which chemotherapy drug would cause Flagellate Erythema ?
Capecitabine
Bleomycin
Doxorubicin
Imatinib
Bleomycin inhibits which of the following
G1
S
G2
M
Bleomycin inhibits which of the following
G1
S
G2
M
Breast cancer
E-cadherin is a phenotypic marker in breast cancer. Describe what levels of E-cadherin would be like in an individual with poor prognosis [1]
Low E-cadherin: worse prognosis
E-cadherin is a cell adhesion molecule that is expressed in normal breast tissue
The loss of E-cadherin expression is a very early change in lobular breast carcinogenesis and the normal protein plays a tumor-suppressive and invasion-suppressive role.
Q
Which drug causesa decline in left ventricular function AND congestive heart failure
Trastuzumab
Pertuzumab
Cetuximab
Kadcycla
Q
Which drug causesa decline in left ventricular function AND congestive heart failure
Trastuzumab
Pertuzumab
Cetuximab
Kadcycla
There are three checkpoints in the cell cycle which allow fidelity of DNA replication and cell division.
Which of the following proteins are most likely to be mutated if a damaged cell does not stop at the G2/M checkpoint?
B-cell lymphoma 2 (Bcl-2)
BRCA 1 (breast cancer 1)
Myc
p53
pRB (retinoblastoma protein)
There are three checkpoints in the cell cycle which allow fidelity of DNA replication and cell division.
Which of the following proteins are most likely to be mutated if a damaged cell does not stop at the G2/M checkpoint?
B-cell lymphoma 2 (Bcl-2)
BRCA 1 (breast cancer 1)
Myc
p53
pRB (retinoblastoma protein)
which of the following work by forming hghly reactive molecules which bind to electron-rich nucleophilic moieties
alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors
which of the following work by forming hghly reactive molecules which bind to electron-rich nucleophilic moieties
alkylating agent
platinum agent
anti-metabolite agent
topoisomerase inhibitors
Q
Which of the following exerts cytotoxic effects by intercalation between guanine-cytosine base pairs with inhibition of the synthesis of messenger RNA
Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan
Q
Which of the following exerts cytotoxic effects by intercalation between guanine-cytosine base pairs with inhibition of the synthesis of messenger RNA
Trabectedin
L-Asparaginase
Actinomycin-D
Busulfan
Q
A mutation of which gene is most strongly associated with colon cancer?
BRCA2
RB1
p53
TSC1
BRCA1
Q
A mutation of which gene is most strongly associated with colon cancer?
BRCA2
RB1
p53
TSC1
BRCA1
Q
A mutation of which gene is most strongly associated with colon cancer?
BRCA2
RB1
p53
TSC1
BRCA1
Q
A mutation of which gene is most strongly associated with colon cancer?
BRCA2
RB1
p53
TSC1
BRCA1
3 Measurement of neonatal plasma concentrations of this substance is used as a predictive test for the condition of congenital hypothyroidism.
A. desmopressin
B. mono-iodotyrosine
C. oxytocin
D. thyroglobulin
E. thyrotrophin
3 Measurement of neonatal plasma concentrations of this substance is used as a predictive test for the condition of congenital hypothyroidism.
A. desmopressin
B. mono-iodotyrosine
C. oxytocin
D. thyroglobulin
E. thyrotrophin
State another name for TSH [1]
Thyrotrophin
[] recycles the iodine contained in MIT and DIT as they are released from thyroglobulin within the thyroid follicular cell.
A. desmopressin
B. mono-iodotyrosine
C. oxytocin
D. thyroglobulin
E. thyrotrophin
**B. mono-iodotyrosine **
4 For the treatment of Graves’ disease, carbimazole is the anti-thyroid drug of choice.
Carbimazole works by inhibiting which of the following compounds.
A. cholinesterase
B. de-iodinase
C. Na / K ATP-ase
D. lactase
E. thyroperoxidase
4 For the treatment of Graves’ disease, carbimazole is the anti-thyroid drug of choice.
Carbimazole works by inhibiting which of the following compounds.
A. cholinesterase
B. de-iodinase
C. Na / K ATP-ase
D. lactase
E. thyroperoxidase
8 Graves’ disease involves the binding of immunoglobulin antibodies to receptors located on thyroid follicular cells. Which is the naturally occurring hormone that normally binds to such receptors?
A. Thyroperoxidase
B. Thyrotrophin
C. Thyrotrophin releasing hormone
D. Thyroxine
E. Tri-iodothyronine
8 Graves’ disease involves the binding of immunoglobulin antibodies to receptors located on thyroid follicular cells. Which is the naturally occurring hormone that normally binds to such receptors?
A. Thyroperoxidase
B. Thyrotrophin : aka TSH
C. Thyrotrophin releasing hormone
D. Thyroxine
E. Tri-iodothyronine
Correct response: B
Benign enlargement of the prostate gland can narrow the bladder neck and impede the outflow of urine. This drug relaxes the smooth muscle of the bladder neck region and improves urine flow.
A. Acetylcholine
B. Nicotine
C. Pancuronium
D. Propranolol
E. Tamsulosin
Benign enlargement of the prostate gland can narrow the bladder neck and impede the outflow of urine. This drug relaxes the smooth muscle of the bladder neck region and improves urine flow.
A. Acetylcholine
B. Nicotine
C. Pancuronium
D. Propranolol
E. Tamsulosin
Describe the MoA of tamsulosin [1]
alpha 1 adrenoreceptor blocker of the prostate: by blocking these adrenoceptors, smooth muscle in the prostate is relaxed and urinary flow is improved.