QTS cards - Respiratory

Question 1

H1 blocker

Diphenhydramine
dimenhydrinate
chlorpheniramine

Answer 1

avoid in elderly (INC sedation)

AE - anitmuscarinic (e.g. myadrisis, facial flushing, urinary retention, constipation)

Question 2

H2 blocker

LoratADINE

Answer 2

dec CNS AE

Question 3

Pseudoepinephrine

Phenylephrine

Answer 3

nasal decongestant

alpha adrenergic agonist

Tachyphylaxis
overuse –> NEG feedback –> Dec NE synthesis Dec relate from nerve ending –> Dec effect

Question 4

bosENtAN

Answer 4

ENdothelin receptor ANtagonist

TX - pulmonary HTN

competitively antagonize endothelin-1 receptors -> DEC pulmonary vascular resistance

Question 5

Albuterol

Answer 5

B2 agonist - INC cAMP (bronchodilation)

tx - acute asthma attack

Question 6

fluticasone

budesonide

Answer 6

TX - chronic asthma

inactive NF-kB (no inflammatory TNFa or agents made)

Question 7

ipratropiuM

Answer 7

Muscarinic antagonist

no Ach (from vagus) - NO bronchoconstriction

Question 8

monteLUKast

Answer 8

antiLEUKotrienes (block receptor)

TX - aspirin, exercise, atopy asthma

Question 9

omaLIzumab

Answer 9

anti-IgE antibody

tx - allergic asthma

Question 10

theophylline

Answer 10

methylxanthines

inhibit phosphodiesterase -> INC cAMP (bronchodilation)

AE - seizures and tachyarrythmia =(

cyp450

Question 11

inhaled glucocorticoids AE

Answer 11

oral candidiasis

prevent by rinsing after use

Question 12

Nitric Oxide

Answer 12

tx pulmonary hypertension of newborn