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STEP 1 > QTS cards - Pharm (Biochem, Micro, Immune, Pharm Section FA) > Flashcards

QTS cards - Pharm (Biochem, Micro, Immune, Pharm Section FA) Flashcards

1
Q

Cyclosporine

Tacrolimus

A

immunosuppressant
Inhibit Calcineurin
prevent IL-2 transcription (DEC proliferation.differentation of T lymphocytes)

metabolized by CYP450
inhibit by GRAPEFRUIT

CYCLO - highest toxicity - narrow spectrum

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2
Q

AzathioPRINE

6-MCP

A

precursor of 6-mercaptoPURINE
activated by HGPRT

INC toxicity with allopurinol (inhibit xanthine oxidase)

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3
Q

RiTUXimab

A

CD20

b-cell non-hodgkin lymphoma

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4
Q

OmALiZumab

A

anti-IgE antibody
ALlergic aZthma
dec dependency on steroids

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5
Q

RANIbizumab

bEVacizumab

A

anti-VEGF

neovascular age-related macular degeneration

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6
Q

ACH direct agonist AE

A

nausea, vomit, abdominal cramps, diarrhea, dyspnea, INC secretion (sweat, lacrimation, salivation)

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7
Q

Bethanechol

A

direct ACH agonist
TX - atonic bladder (non obstructive bladder)

activates bowel and bladder smooth muscle
resistant to AChE

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8
Q

Methacholine

A

Muscarinic
Challenge text for ASTHMA
(NEG = NO asthma)

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9
Q

edroPHONium

A 
INDIRECT agonist (ANTIAChE)
tension test for MG
Improve with RX - INC pyridostigmine dose
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10
Q

PHYSostigmine

A 
INDIRECT agonist (ANTIAChE)
TX - ATROPINE overdose (anticholinergic toxicity)
TX- Jimson weed - gardener pupil myadrisis
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11
Q

pyridostigmine

A

MG

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12
Q

SCOPOlamine

A

selective muscarinic Ach receptor antagonist

motion sickness
tx x AE of Ach inhibitor

AE - dry mouth

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13
Q

Albuterol

A

B2 agonist

acute asthma

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14
Q

Salmeterol

A

B2 agonist

long term asthma or COPD

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15
Q

Phentolamine

A

reversible A-block

tx - NE extravation

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16
Q

-Osin

A

A1 - block selective

TX - BPH, HTN

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17
Q

Esmolol, Metoprolol

ECG effect

A

B- Blocker
prolong PR interval
tx - SVT (dec AV conduction)

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18
Q

B1-Blocker

HTN tx

A 
B1 = A to M
Dec Heart
DEC renin secretion 
JGA block
no change in bradykinin
19
Q

B-Block

MI

A

DEC mortality

20
Q

B-Blocker CI

A

in pts with asthma, COPD

21
Q

B1- block selective

A-M

A

pts with lung problem
coronary artery dz
HF, HTN

22
Q

Nonelective B-block

N-Z

A

B1 = B2

23
Q

propanolol

A

DEC peripheral conversion of T4-T3
Inhibit iodothyronine deiodinase

dec sympathetic - dec thyrotoxic sx

24
Q

Sirolimus

A

inhibits mTOR

prevent IL2 response

25
Q

Oral retinoic acid

isotretinoin

A

TX - acne
CI in pregnancy (check B-hCG)
A toxicity

26
Q

atropine

Jimson weed

A

muscarinic antagonist
toxicity: Hot, Dry, Red - flushed skin, cyclopedia, Mad (confuse, delirium, psychosis, disorientation)

does NOT reverse skeletal or CNS toxicity - bc nicotinic

TX x overdose - Physostigmine

AE - acute angle closure glaucoma

27
Q

phenoxybenzamine

A

TX pheochromocytoma
pre-op to prevent catecholamine HTN crisis

Competitive antagonist of Ne (Dec Vmax; irreversible bind alpha receptors)

28
Q

PILOcarpine

A 
muscarinic agonist
Pupillary constriction (contrast ciliary muscle, pupillary sphincter)

stimulates share, tears, saliva

29
Q

Infliximab

Adalimumab

A

antibody to TNF-a

30
Q

eTaNerCEPT

A

recombinant/decoy TNF-a receptor

31
Q

Isoprotenerol

A

B1=B2
Dec vascular resistance (vasodilation)
Inc cardiac contractility

32
Q

Milrinone

A

Inhibit PDE3
INC Ca –> Inc contractility
INC cAMP –> Inc vasodilation

33
Q

CYP 450 Inducers

A 
Carbamazepine
Griseofulvin
Phenobarbital
Phenytoin
Rifampin
34
Q

CYP450 Inhibitors

A 
Azole anti fungal
Cimetidine
Ciprofloxacin
Erythromycin
Grapefruit juice
Isoniazid
Ritonavir (protease inhibitor)
35
Q

Timolol

A

Dec secretion of aqueous humor - glaucoma

target ciliary epithelium

36
Q

TX: HF to increase survival

A

B-Blockers
ACE inhibitors
Angiotensin II receptor blocker
aldosterone antagonists (spironolactone, eplerenone)

37
Q

diMERCApROL

A

antidote
MERCury
Arsenic (garlic breath)
gOLd

38
Q

abSIXimab

A

gp IIa/IIIb antagonist (2x3=6)

NO platelet plug

39
Q

vireNICLINE

A

partial agonist of nicotinic acetylcholine receptor

Dec craving, Dec pleasure of nicotine
nicotine decline

40
Q

DObutamine

A

D1=D2 > B > a

via Gs protein-adenylate cyclase activation

41
Q

Methotrexate

A

can be rescue with Leucovorin (N5- formyl tetrahydrofolate)

Fluorouracil 5-FU cannot

42
Q

essential tremor tx

A

B-blocker

43
Q

rasbURIcase

A

recombinant version of rate oxidase

converts uric acid into allantoin (soluble metabolite)

STEP 1 (12 decks)

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