QTS cards - Musculoskeletal, Skin, Connective tissue

Question 1

Aspirin

Answer 1

TX - TIA - prevent stroke

Irreversible inhibit COX
Dec TXA2 –> DEC platelet aggregation
Dec Prostaglandin

AE - Gastric ulcer, GI bleed

Question 2

cElECOXib

Answer 2

reversible Inhibit COX2

use in pts with hematuria, pain, fever

Question 3

NSAIDs

Answer 3

block prostaglandin synthesis - Inhibit vasodilating prostaglandins at the afferent arteriole
(inhibit loop diuretic effect)

AE - upper GI heme

Question 4

Gout TX acute

Answer 4

NSAIDs
colchine
glucocorticoids

Question 5

Colchicine

Answer 5

@cytoskeleton
stabilized tubulin - inhibit MT polymerization, impair neutrophil chemotaxis (low Leukotriene B4) and degranulation

AE - DIARRHEA

use in pts w/ RF, hx of PUD, of CI to NSAIDs

Question 6

eTaNerCEPT

Answer 6

TNF decor receptor

impairs mycobacteria fight - do TB test before rx

Question 7

Probenecid

Answer 7

Inhibits renal tubular secretion of penicillin

Question 8

Bisphosphonates

“DRONATES”

Answer 8

Pyrophosphate analog

inhibit mature osteoclast mediated bone resorption
slow bone destruction