QTS cards - GI Pharm

Question 1

lactulose

rifaximin

Answer 1

TX hepatic encephalopathy

Question 2

PENIcillamine

Answer 2

copper = Wilson’s tx

Question 3

Ondansetron

Answer 3

5-HT3 antagonist

TX control vomit (chemo pts)

Question 4

Misoprostol

Answer 4

prostaglandin E analog

dec acid production - TX ulcer

Question 5

octreotide

Answer 5

TX - carcinoid tumor, acromegaly

somatostatin analog
Inhibit release of bioactive peptides by tumor causing flushing, diarrhea

Question 6

Cimetidine

Answer 6

CYP450 Inhibitor

slows metabolism of warfarin (gradual INC in PT)

Question 7

lactulose

Answer 7

TX hepatic encephalopathy

via intestinal content acidification (colonic bacteria –> INC NH4 excretion)

Question 8

somatostatin

Octreotide

Answer 8

TX - acromegaly, insulinoma, carcinoid syndrome, vatical bleeding (bleeding esophageal varices)

Question 9

Repaglinide

Nateglinide

Answer 9

close K channel in B cell –> depolarization –> Inc insulin release via Inc Ca influx

Question 10

Omeprazole

PPI

Answer 10

irreversibly inhibit H/K ATPase in stomach parietal cells
inhibit effects of vans, histamine, gastrin
Inhibit active transport

AE - osteoporosis (dec Ca bc dec acidic environment)

Question 11

orLISTAt

Answer 11

weight loss

inhibits enzymes that break down fat (gastric and pancreatic lipase)

Question 12

Sulfasalazine

Answer 12

UC, Chron’s (colitis)

sulfa + 5’AA (antibacterial + antiinflammatory)

activated by colonic bacteria