QTS cards - Endo Pharm Flashcards
Bromocriptine
Dopamine agonist
inhibit prolactin secretion
desmopressin acetate
ADH analog
TX x central DI
PropylThioUracil
inhibits thyroid peroxidase,
blocks coupling of iodine
block Peripheral conversion (5’-deiodinase)
tx hyperthyroidism
safe in pregnancy
Metyrapone
blocks last step of cortisol synthesis
(11-deoxycortiol –> cortisol)
normal response = INC ACTH surge
adrenal insufficiency = no ACTH surge
Hydrocortison/Dexamethasone
+ IV fluids
TX acute adrenal crisis (bc severe hypotension)
1) Phynoxybenzamine
2) B-Blocker
TX pheochromocytome
1) Phynoxybenzamine - a-antagonist
2) B-Blocker-prior to tumor resection
PeGvisomANT
GH receptor ANTagonist
TX acromegaly
IV insulin - regular
TX diabetic ketoacidos
+ IV fluids, K
glitazones
thiazolidinediones
binds PPAR-Y intracellular nuclear transcription
Inc insulin sensitivity in peripheral tissue
regulator
oral hypoglycemic rx
Induces differentiation of preadipocytes into adipocytes
Inc GLUT-4 expression on adipose cell membrane
AE - GLUTON (weight gain, edema)
canaglifozin
SGLT-2-Inhbitor
AE - Glycosuria, UTI, vaginal yeast infection
TEST before: blood urea, N2, creatine
glucocorticoids AE
Cushing’s, hyperglycemia
Inc hepatic gluconeogenesis, glycogenesis
INC anabolic protein synthesis
Neutrophilia (INC neutrophils)
Dec lymphocyte, monocyte, basophil, eosinophil
insulin - rapid acting
Aspart
Glulisine
Lispro
binds insulin receptor (tyrosine kinase activity)
post prandial control
2-4 hrs
Metformin
AE - lactic acidosis
CI x renal insufficiency pts - check CREATINE
Thionamines AE
PTU, Methimazole
agranulocytosis
(fever, sore throat, oral ulceration)
Stop RX
get WBC count with differential
2nd - sulfonylureas
Glyburide
glimepiridine
INC risk of hypoglycemia
